| Pub ID | Title | Author(s) | Year | Journal |
|---|
| 7222 | Socioecological approach for identifying the determinants of objectively measured physical activity: A prospective study of the UK Biobank | Jaesung Choi (+8) | 2021 | Preventive Medicine |
| 7431 | Parameters of Chronic Kidney Disease to Identify Outpatients at Increased Risk for COVID-19 Mortality: A Cohort Study of UK Biobank Participants | Anusua Trivedi (+6) | 2021 | The Open Urology & Nephrology Journal |
| 10885 | Relationship Between Fish Oil Use and Incidence of Primary Liver Cancer: Findings From a Population-Based Prospective Cohort Study | Wei Jiang (+4) | 2021 | Frontiers in Nutrition |
| 12634 | Reproductive factors and the risk of incident dementia: Results from the UK Biobank | Jessica Gong (+3) | 2021 | Alzheimer's & Dementia |
| 12635 | Auditory outcome following aneurysmal subarachnoid haemorrhage | Ben Gaastra (+4) | 2021 | Journal of the Neurological Sciences |
| 7223 | Higher educational attainment is associated with longer telomeres in midlife: Evidence from sibling comparisons in the UK Biobank | Vikesh Amin (+3) | 2021 | SSM - Population Health |
| 7432 | Genomic insights in ascending aortic size and distensibility | Jan Walter Benjamins (+8) | 2021 | EBioMedicine |
| 12636 | Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene | Mengyuan Kan (+16) | 2021 | Journal of Allergy and Clinical Immunology |
| 5356 | Maternal occupational exposure to endocrine-disrupting chemicals and urogenital anomalies in the offspring | Spinder N et al. | 2021 | Hum Reprod |
| 10882 | The association of anxiety and stress-related disorders with C-reactive protein (CRP) within UK Biobank | Emma Kennedy (+1) | 2021 | Brain Behavior & Immunity - Health |
| 10883 | Patch individual filter layers in CNNs to harness the spatial homogeneity of neuroimaging data | Fabian Eitel (+4) | 2021 | Scientific Reports |
| 10884 | Self-reported regular daytime napping is associated with indicators of poor type 2 diabetes control: A cohort study | Pei Xue (+3) | 2021 | Diabetes Obesity and Metabolism |
| 7224 | Outlier detection in multimodal MRI identifies rare individual phenotypes among more than 15,000 brains | Zhiwei Ma (+4) | 2021 | Human Brain Mapping |
| 12637 | Obesity increases heart failure incidence and mortality: observational and Mendelian randomization studies totalling over 1 million individuals | Marianne Benn (+3) | 2021 | Cardiovascular Research |
| 10881 | Selenium and cancer risk: Wide-angled Mendelian randomization analysis | Shuai Yuan (+6) | 2021 | International Journal of Cancer |
| 12638 | Absolute and relative grip strength as predictors of cancer: prospective cohort study of 445 552 participants in UK Biobank | Solange Parra-Soto (+3) | 2021 | Journal of Cachexia Sarcopenia and Muscle |
| 7225 | A summary-statistics-based approach to examine the role of serotonin transporter promoter tandem repeat polymorphism in psychiatric phenotypes | Arunabha Majumdar (+3) | 2021 | European Journal of Human Genetics |
| 7226 | Meta-Analysis of Transcriptome-Wide Association Studies across 13 Brain Tissues Identified Novel Clusters of Genes Associated with Nicotine Addiction | Zhenyao Ye (+9) | 2021 | Genes |
| 10879 | Cardiac Magnetic Resonance Radiomics Reveal Differential Impact of Sex, Age, and Vascular Risk Factors on Cardiac Structure and Myocardial Tissue | Zahra Raisi-Estabragh (+9) | 2021 | Frontiers in Cardiovascular Medicine |
| 10880 | Rare coding variants in DNA damage repair genes associated with timing of natural menopause | Lucas D. Ward (+6) | 2021 | Human Genetics and Genomics Advances |
| 12639 | The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression | Gita A. Pathak (+9) | 2021 | Amyloid |
| 7227 | Alcohol consumption and risk of ventricular arrhythmias and sudden cardiac death: An observational study of 408,712 individuals | Samuel J Tu (+8) | 2021 | Heart Rhythm |
| 10878 | Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization | Swetta A. Jansen (+7) | 2021 | GeroScience |
| 7228 | Physical work exposure matrix for use in the UK Biobank | E L Yanik (+7) | 2021 | Occupational Medicine |
| 10875 | Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification | Yi Ding (+7) | 2021 | Nature Genetics |
| 10876 | Machine Learning Approach to Classify Cardiovascular Disease in Patients With Nonalcoholic Fatty Liver Disease in the UK Biobank Cohort | Divya Sharma (+5) | 2021 | Journal of the American Heart Association |
| 10877 | Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis | Marios K Georgakis (+3) | 2021 | Journal of the American Heart Association |
| 10873 | The genetic architecture of language functional connectivity | Yasmina Mekki (+6) | 2021 | NeuroImage |
| 10874 | Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension | Zimin Song (+9) | 2021 | Cardiovascular Diabetology |
| 7229 | A Network-Based Analysis of Disease Complication Associations for Obstetric Disorders in the UK Biobank | Vivek Sriram (+6) | 2021 | Journal of Personalized Medicine |
| 10871 | Genome-Wide Association Study of 2,093 Cases With Idiopathic Polyneuropathy and 445,256 Controls Identifies First Susceptibility Loci | Bendik S. Winsvold (+6) | 2021 | Frontiers in Neurology |
| 10872 | Age- and Sex-Related Topological Organization of Human Brain Functional Networks and Their Relationship to Cognition | Heidi Foo (+6) | 2021 | Frontiers in Aging Neuroscience |
| 12640 | Polygenic Risk Score Prediction for Endometriosis | Kirstine Kloeve-Mogensen (+11) | 2021 | Frontiers in Reproductive Health |
| 7230 | Diet and Dementia: A Prospective Study | Hikaru Takeuchi (+1) | 2021 | Nutrients |
| 7231 | Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank | Xiaomeng Zhang (+10) | 2021 | British Journal of Cancer |
| 7232 | Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study | Zahra Raisi-Estabragh (+9) | 2021 | European Heart Journal - Cardiovascular Imaging |
| 7233 | Investigating ethnic inequalities in hearing aid use in England and Wales: a cross-sectional study | Harry Taylor (+4) | 2021 | International Journal of Audiology |
| 10870 | The genetic architecture of human cortical folding | Dennis van der Meer (+16) | 2021 | Science Advances |
| 10869 | Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan | Yunpeng Wang (+16) | 2021 | Brain Behavior and Immunity |
| 7433 | Genetic determinants of liking and intake of coffee and other bitter foods and beverages | Marilyn C. Cornelis (+1) | 2021 | Scientific Reports |
| 10868 | Curating a longitudinal research resource using linked primary care EHR data - a UK Biobank case study | Philip Darke (+5) | 2021 | Journal of the American Medical Informatics Association |
| 12641 | Heart rate response and recovery during exercise predict future delirium risk - A prospective cohort study in middle- to older-aged adults | Lei Gao (+7) | 2021 | Journal of Sport and Health Science |
| 12642 | Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index | April Hartley (+62) | 2021 | International Journal of Epidemiology |
| 8171 | Association of Ethnicity and Socioeconomic Status With COVID-19 Hospitalization and Mortality in Those With and Without Chronic Kidney Disease | Thomas J. Wilkinson (+5) | 2021 | Kidney International Reports |
| 7234 | Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen | Diego Lucero (+14) | 2021 | Journal of Lipid Research |
| 7235 | Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics | Xiaoguang Xu (+12) | 2021 | Cardiovascular Research |
| 10867 | Associations of genetic susceptibility to 16 cancers with risk of breast cancer overall and by intrinsic subtypes | Jungyoon Choi (+6) | 2021 | Human Genetics and Genomics Advances |
| 12643 | Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study | Harshal Deshmukh (+6) | 2021 | Bone |
| 7236 | Depressive symptoms and neuroticism-related traits are the main factors associated with wellbeing independent of the history of lifetime depression in the UK Biobank | Chiara Fabbri (+3) | 2021 | Psychological Medicine |
| 7237 | Clustering Accelerometer Activity Patterns from the UK Biobank Cohort | Stephen Clark (+4) | 2021 | Sensors |
| 10866 | Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype | Sarah R. Senum (+28) | 2021 | American Journal of Human Genetics |
| 12644 | The power of genetic diversity in genome-wide association studies of lipids | Sarah E. Graham (+525) | 2021 | Nature |
| 10763 | Causal effects of inflammatory protein biomarkers on inflammatory diseases | Weronica E Ek (+4) | 2021 | Science Advances |
| 10764 | GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome | Ferdinando Bonfiglio (+26) | 2021 | Cell Genomics |
| 10865 | Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors | Wenhan Chen (+6) | 2021 | Nature Communications |
| 12645 | Machine learning enables new insights into genetic contributions to liver fat accumulation | Mary E. Haas (+16) | 2021 | Cell Genomics |
| 12646 | Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake | Nora Eszlari (+10) | 2021 | Nutrients |
| 7238 | The Association of Ambient Air Pollution With Cataract Surgery in UK Biobank Participants: Prospective Cohort Study | Sharon Y. L. Chua (+7) | 2021 | Investigative Ophthalmology & Visual Science |
| 10761 | Disparities in COVID-19 infection, hospitalisation and death in people with schizophrenia, bipolar disorder, and major depressive disorder: a cohort study of the UK Biobank | Lamiece Hassan (+6) | 2021 | Molecular Psychiatry |
| 10762 | Polygenic risk for coronary artery disease in the Scottish and English population | Chuhua Yang (+7) | 2021 | BMC Cardiovascular Disorders |
| 12647 | Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution | Mine Koprulu (+29) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 12648 | Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance | Yizhe Gao (+14) | 2021 | Alzheimer's & Dementia |
| 12649 | Development and Validation of Decision Rules Models to Stratify Coronary Artery Disease, Diabetes, and Hypertension Risk in Preventive Care: Cohort Study of Returning UK Biobank Participants | José Castela Forte (+7) | 2021 | Journal of Personalized Medicine |
| 12650 | Causal effects from non-alcoholic fatty liver disease on kidney function: A Mendelian randomization study | Sehoon Park (+12) | 2021 | Liver International |
| 12651 | Shared genetic influences on depression and menopause symptoms | Joeri J. Meijsen (+5) | 2021 | Psychological Medicine |
| 7239 | No Evidence That Genetic Variation at the Klotho Locus Is Associated With Longevity in Caucasians from the Newcastle 85+ Study and the UK Biobank | Hasnat A Amin (+6) | 2021 | The Journals of Gerontology Series A |
| 12379 | Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk | Ang Zhou (+2) | 2021 | European Heart Journal |
| 10759 | Major sex differences in migraine prevalence among occupational categories: a cross-sectional study using UK Biobank | Oreste Affatato (+3) | 2021 | The Journal of Headache and Pain |
| 10760 | Efficient approaches for large-scale GWAS with genotype uncertainty | Emil Jørsboe (+1) | 2021 | G3: Genes, Genomes, Genetics |
| 10757 | Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes. | Mark J O'Connor (+19) | 2021 | Diabetes |
| 10758 | Stronger Associations Between Sleep and Mental Health in Adults with Autism: A UK Biobank Study | Lisa M. Henderson (+5) | 2021 | Journal of Autism and Developmental Disorders |
| 12652 | Regular use of proton-pump inhibitors and risk of stroke: a population-based cohort study and meta-analysis of randomized-controlled trials | Man Yang (+15) | 2021 | BMC Medicine |
| 7240 | Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank. | Han Han (+8) | 2021 | Diabetes Care |
| 10750 | Mapping the serum proteome to neurological diseases using whole genome sequencing | Grace Png (+15) | 2021 | Nature Communications |
| 10751 | Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status | Joëlle A. Pasman (+14) | 2021 | Behavior Genetics |
| 10752 | Fast estimation of genetic correlation for biobank-scale data | Yue Wu (+5) | 2021 | American Journal of Human Genetics |
| 10753 | Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation | R. J. Longchamps (+51) | 2021 | Human Genetics |
| 10754 | Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen | May E. Montasser (+38) | 2021 | Science |
| 10755 | Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank | Fanny Petermann-Rocha (+10) | 2021 | BMC Medicine |
| 10756 | Application of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models | Farideh Jalali-najafabadi (+16) | 2021 | Scientific Reports |
| 12653 | Modeling Interaction and Dispersion Effects in the Analysis of Gene-by-Environment Interaction | Benjamin W. Domingue (+4) | 2021 | Behavior Genetics |
| 4141 | Association Between Genetic Risk for Psychiatric Disorders and the Probability of Living in Urban Settings | Jessye M. Maxwell (+3) | 2021 | JAMA Psychiatry |
| 4366 | Blood biomarker levels by total sleep duration: cross-sectional analyses in UK Biobank | Wong TY et al. | 2021 | Sleep Med |
| 4677 | Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank | Xiaoxia Wei (+17) | 2021 | American Journal of Clinical Nutrition |
| 4787 | Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses | Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration. | 2021 | Lancet Diabetes Endocrinol |
| 4955 | Genetic Variation in the Mitochondrial Glycerol-3-Phosphate Acyltransferase Is Associated With Liver Injury | Aaron Hakim (+14) | 2021 | Hepatology |
| 5042 | Genome-wide Association Study of Liver-related Enzymes Suggests Putative Pleiotropic Effects on Diverse Traits and Diseases | Kim HS et al. | 2021 | Hepatology |
| 5507 | Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank | Faber BG et al. | 2021 | Bone |
| 5572 | Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men | Manikpurage HD et al. | 2021 | Circ Genom Precis Med |
| 5577 | Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases | Zhi Yu (+13) | 2021 | Journal of the American Society of Nephrology |
| 5607 | Prevalence of insomnia symptoms and associated risk factors in UK Biobank participants with hazardous alcohol use and major depression | Kolla BP et al. | 2021 | Drug Alcohol Depend |
| 5659 | Regular Use of Proton Pump Inhibitor and the Risk of Inflammatory Bowel Disease: Pooled Analysis of 3 Prospective Cohorts | Xia B et al. | 2021 | Gastroenterology |
| 5687 | Risk Thresholds for Total and Beverage-Specific Alcohol Consumption and Incident Atrial Fibrillation | Tu SJ et al. | 2021 | JACC Clin Electrophysiol |
| 5911 | Total and regional fat-to-muscle mass ratio measured by bioelectrical impedance and risk of incident type 2 diabetes | Wang N et al. | 2021 | J Cachexia Sarcopenia Muscle |
| 8184 | Warped Bayesian linear regression for normative modelling of big data | Charlotte J. Fraza (+3) | 2021 | NeuroImage |
| 10748 | Associations of changes in physical activity and discretionary screen time with incident obesity and adiposity changes: longitudinal findings from the UK Biobank | Susan Paudel (+4) | 2021 | International Journal of Obesity |
| 10749 | Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort | Rebecca A. Kaye (+4) | 2021 | Scientific Reports |
| 12654 | Vitamin D status of British African-Caribbean residents: analysis of the UK Biobank cohort | Rebecca Vearing | 2021 | |
| 12655 | A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens | Wei Liu (+3) | 2021 | BMC Medicine |
| 7434 | Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study | Jie V. Zhao (+1) | 2021 | Scientific Reports |
| 10747 | Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits | Marion Patxot (+12) | 2021 | Nature Communications |
| 7241 | Associations of frailty with cardiovascular disease and life expectancy: A prospective cohort study | Yabing Hou (+10) | 2021 | Archives of Gerontology and Geriatrics |
| 10746 | Association Study of Genetic Variants in Calcium Signaling-Related Genes With Cardiovascular Diseases | Sen Li (+5) | 2021 | Frontiers in Cell and Developmental Biology |
| 12656 | Association Between Inflammatory Bowel Disease and Dementia: A Longitudinal Cohort Study | Yuhao Sun (+7) | 2021 | Inflammatory Bowel Diseases |
| 8185 | Bladder cancer risk variants and overall and disease-specific survival in two independent cohorts | Reno C. Leeming (+5) | 2021 | BJU International |
| 7243 | Evaluation of Early-Life Factors and Early-Onset Colorectal Cancer Among Men and Women in the UK Biobank | Valerie Gausman (+4) | 2021 | Gastroenterology |
| 7435 | Conventional and Bidirectional Genetic Evidence on Resting Heart Rate and Cardiometabolic Traits | Tao Huang (+17) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 10745 | Unhealthy Lifestyle, Genetics and Risk of Cardiovascular Disease and Mortality in 76,958 Individuals from the UK Biobank Cohort Study | Katherine M. Livingstone (+3) | 2021 | Nutrients |
| 10741 | Observational and genetic evidence highlight the association of human sleep behaviors with the incidence of fracture | Yu Qian (+8) | 2021 | Communications Biology |
| 10742 | Combining machine learning and conventional statistical approaches for risk factor discovery in a large cohort study | Iqbal Madakkatel (+3) | 2021 | Scientific Reports |
| 10743 | Deep learning enables genetic analysis of the human thoracic aorta | James P. Pirruccello (+29) | 2021 | Nature Genetics |
| 10744 | Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission | Audinga-Dea Hazewinkel (+3) | 2021 | Economics & Human Biology |
| 10739 | Pathway Association Studies Reveal Gene Loci and Pathway Networks that Associated With Plasma Cystatin C Levels | Hongxiao Jiao (+4) | 2021 | Frontiers in Genetics |
| 10740 | Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank | Adriano Winterton (+7) | 2021 | Translational Psychiatry |
| 7303 | Bayesian model comparison for rare-variant association studies | Guhan Ram Venkataraman (+11) | 2021 | American Journal of Human Genetics |
| 10737 | Loneliness is linked to specific subregional alterations in hippocampus-default network covariation | Chris Zajner (+2) | 2021 | Journal of Neurophysiology |
| 10738 | Integration of Real-World Data and Genetics to Support Target Identification and Validation | Jonathan M. Davitte (+4) | 2021 | Clinical Pharmacology & Therapeutics |
| 4250 | Associations Between Brain Volumes and Cognitive Tests with Hypertensive Burden in UK Biobank | Newby D et al. | 2021 | J Alzheimers Dis |
| 5618 | Protein Nutritional Status and Frailty: A Mendelian Randomization Study | Yasutake Tomata (+3) | 2021 | Journal of Nutrition |
| 10735 | The MUC5B Promoter Polymorphism Associates With Severe COVID-19 in the European Population | Coline H. M. van Moorsel (+8) | 2021 | Frontiers in Medicine |
| 10736 | MOCOnet: Robust Motion Correction of Cardiovascular Magnetic Resonance T1 Mapping Using Convolutional Neural Networks | Ricardo A. Gonzales (+9) | 2021 | Frontiers in Cardiovascular Medicine |
| 5027 | Genome-wide association study identifies 18 novel loci associated with left atrial volume and function | Ahlberg G et al. | 2021 | Eur Heart J |
| 4959 | Genetically determined cutaneous nevi and risk of cancer | Jean Claude Dusingize (+7) | 2021 | International Journal of Cancer |
| 3989 | Adiposity by Differing Measures and the Risk of Cataract in the UK Biobank: The Importance of Diabetes | Xianwen Shang (+11) | 2021 | Investigative Ophthalmology & Visual Science |
| 4690 | Diet-Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People | Leon G. Martens (+5) | 2021 | Journal of the American Heart Association |
| 5410 | Molecular and in vivo phenotyping of missense variants of the human glucagon receptor | Wijnand J.C. van der Velden (+7) | 2021 | Journal of Biological Chemistry |
| 10732 | Novel disease associations with schizophrenia genetic risk revealed in ~400,000 UK Biobank participants | Ruyue Zhang (+5) | 2021 | Molecular Psychiatry |
| 10733 | Hospitalisation events in people with chronic kidney disease as a component of multimorbidity: parallel cohort studies in research and routine care settings | Michael K. Sullivan (+10) | 2021 | BMC Medicine |
| 10734 | Sociodemographic factors associated with treatment-seeking and treatment receipt: cross-sectional analysis of UK Biobank participants with lifetime generalised anxiety or major depressive disorder | Christopher Rayner (+12) | 2021 | BJPsych Open |
| 12657 | Evidence From Men for Ovary-independent Effects of Genetic Risk Factors for Polycystic Ovary Syndrome | Jia Zhu (+6) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 5076 | Genomic predictors of testosterone levels are associated with muscle fiber size and strength | João Paulo L. F. Guilherme (+6) | 2021 | European Journal of Applied Physiology |
| 10596 | Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study | Zhi-Hao Li (+17) | 2021 | Frontiers in Cardiovascular Medicine |
| 12658 | Breast and prostate cancer risk: The interplay of polygenic risk, rare pathogenic germline variants, and family history | Emadeldin Hassanin (+9) | 2021 | Genetics in Medicine |
| 5999 | Warped Bayesian linear regression for normative modelling of big data. | Charlotte J Fraza (+3) | 2021 | NeuroImage |
| 7244 | Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank | Lijie Wang (+6) | 2021 | Frontiers in Oncology |
| 10595 | Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health | Geng Wang (+9) | 2021 | Hypertension |
| 12659 | White matter, cognition and psychotic-like experiences in UK Biobank | M. J. Bosma (+8) | 2021 | Psychological Medicine |
| 4598 | Consumption of coffee and tea and risk of developing stroke, dementia, and poststroke dementia: A cohort study in the UK Biobank | Yuan Zhang (+4) | 2021 | PLOS Medicine |
| 4612 | COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank | Can Hou (+11) | 2021 | BMC Medicine |
| 5115 | Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals | Zhiqiang Sha (+9) | 2021 | Proceedings of the National Academy of Sciences of the United States of America |
| 5148 | Hospital management of major stroke types in Chinese adults: a population-based study of 20 000 hospitalised stroke cases | Qin H et al. | 2021 | BMJ Open |
| 10593 | Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort | Rebecca M. Vearing (+7) | 2021 | Nutrients |
| 10594 | Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort | Melis Anatürk (+4) | 2021 | Frontiers in Aging Neuroscience |
| 5411 | Molecular epidemiology of extended-spectrum beta-lactamase-producing extra-intestinal pathogenic Escherichia coli strains over a 2-year period (2017-2019) from Zimbabwe | Takawira FT et al. | 2021 | Eur J Clin Microbiol Infect Dis |
| 10592 | Genetic architecture of orbital telorism | Maria J Knol (+13) | 2021 | Human Molecular Genetics |
| 12660 | A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients | Christopher Wills (+24) | 2021 | European Journal of Cancer |
| 7436 | Association of chronic musculoskeletal pain with mortality among UK adults: A population-based cohort study with mediation analysis | Lingxiao Chen (+10) | 2021 | EClinicalMedicine |
| 7596 | White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study | Karolina A Wartolowska (+1) | 2021 | Cerebrovascular and Brain Metabolism Reviews |
| 4874 | Fusobacterium nucleatum and oral cancer: a critical review | McIlvanna E et al. | 2021 | BMC Cancer |
| 10591 | Mutagenesis of human genomes by endogenous mobile elements on a population scale | Nelson T. Chuang (+8) | 2021 | Genome Research |
| 12661 | Mapping the proteo-genomic convergence of human diseases | Maik Pietzner (+20) | 2021 | Science |
| 4993 | Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions | Samar Khoury (+31) | 2021 | Brain |
| 4997 | Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics | Zihuai He (+17) | 2021 | American Journal of Human Genetics |
| 10590 | Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes | Junhao Wen (+30) | 2021 | Medical Image Analysis |
| 4692 | Differences in Clinical Features and Comorbid Burden between HLA-C ∗06:02 Carrier Groups in >9,000 People with Psoriasis | Konstantinos Douroudis (+114) | 2021 | Journal of Investigative Dermatology |
| 5233 | Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change | Didac Vidal-Pineiro (+30) | 2021 | eLife |
| 5338 | Long-Term Cognitive Outcome following Aneurysmal Subarachnoid Haemorrhage | Ben Gaastra (+4) | 2021 | Journal of Stroke and Cerebrovascular Diseases |
| 5826 | The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses | Rasheed H et al. | 2021 | Int J Epidemiol |
| 7245 | Mapping Complex Brain Torque Components and Their Genetic Architecture and Phenomic Associations in 24,112 Individuals | Lu Zhao (+4) | 2021 | Biological Psychiatry |
| 5685 | Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations | Flatby HM et al. | 2021 | Clin Microbiol Infect |
| 10589 | The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare | Ken B. Hanscombe (+6) | 2021 | Genome Medicine |
| 12662 | Accelerometer-derived sleep onset timing and cardiovascular disease incidence: a UK Biobank cohort study | Shahram Nikbakhtian (+6) | 2021 | European Heart Journal - Digital Health |
| 12663 | Genome-wide by Environment Interaction Study of Stressful Life Events and Hospital-Treated Depression in the iPSYCH2012 Sample | Nis P. Suppli (+22) | 2021 | Biological Psychiatry Global Open Science |
| 4370 | Blood Pressure, Hypertension, and the Risk of Aortic Dissection Incidence and Mortality: Results From the J-SCH Study, the UK Biobank Study, and a Meta-Analysis of Cohort Studies | Makoto Hibino (+22) | 2021 | Circulation |
| 4468 | Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction | Dong Jun Kim (+9) | 2021 | Scientific Reports |
| 4495 | Circulating insulin-like growth factor-I and risk of 25 common conditions: outcome-wide analyses in the UK Biobank study | Keren Papier (+8) | 2021 | European Journal of Epidemiology |
| 5389 | Metabolic and genetic determinants for progression to severe liver disease in subjects with obesity from the UK Biobank | Antonio De Vincentis (+10) | 2021 | International Journal of Obesity |
| 10587 | Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila | Neha Agrawal (+8) | 2021 | PLOS Biology |
| 10588 | Estimating disease prevalence in large datasets using genetic risk scores | Benjamin D. Evans (+9) | 2021 | Nature Communications |
| 4184 | Association of comprehensive mental health with incident cardiovascular disease: A prospective cohort study | Huiping Li (+9) | 2021 | Journal of Affective Disorders |
| 4241 | Association of visual impairment with risk for future Parkinson's disease | Zhuoting Zhu (+12) | 2021 | EClinicalMedicine |
| 4460 | Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study | Michael Drozd (+7) | 2021 | Journal of the American Heart Association |
| 4511 | Citrus-Gene interaction and melanoma risk in the UK Biobank | Andrew R. Marley (+5) | 2021 | International Journal of Cancer |
| 4996 | Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders | Chris Eijsbouts (+28) | 2021 | Nature Genetics |
| 5863 | The Identification of Blood Biomarkers of Chronic Neuropathic Pain by Comparative Transcriptomics | Islam B et al. | 2021 | Neuromolecular Med |
| 10511 | Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake | Magdalena Zimoń (+14) | 2021 | Nature Communications |
| 10586 | Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes | Claire Prince (+2) | 2021 | American Journal of Human Genetics |
| 3875 | A generalized linear mixed model association tool for biobank-scale data | Longda Jiang (+3) | 2021 | Nature Genetics |
| 4317 | Assortative mating and within-spouse pair comparisons | Laurence J. Howe (+6) | 2021 | PLOS Genetics |
| 4884 | Genetic Analyses of Common Infections in the Avon Longitudinal Study of Parents and Children Cohort | Amanda H. W. Chong (+6) | 2021 | Frontiers in Immunology |
| 5993 | Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study | Ryan Arathimos (+8) | 2021 | Translational Psychiatry |
| 4275 | Associations between smoking and accelerated brain ageing | Zeqiang Linli (+3) | 2021 | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| 4880 | Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes | Goncalo Abecasis (+129) | 2021 | Scientific Reports |
| 5504 | Oral Antidiabetics and Sleep Among Type 2 Diabetes Patients: Data From the UK Biobank | Pei Xue (+4) | 2021 | Frontiers in Endocrinology |
| 10495 | The Influence of CYP2D6 and CYP2C19 Genetic Variation on Diabetes Mellitus Risk in People Taking Antidepressants and Antipsychotics | Isabelle Austin-Zimmerman (+14) | 2021 | Genes |
| 10585 | Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease | Nooshin Ghodsian (+20) | 2021 | Cell Reports Medicine |
| 12664 | MC3R links nutritional state to childhood growth and the timing of puberty | B. Y. H. Lam (+39) | 2021 | Nature |
| 12665 | Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project | Yao Hu (+39) | 2021 | Stroke |
| 4054 | An integrative analysis of genomic and exposomic data for complex traits and phenotypic prediction | Xuan Zhou (+1) | 2021 | Scientific Reports |
| 4461 | CD36 maintains the gastric mucosa and associates with gastric disease | Miriam Jacome-Sosa (+15) | 2021 | Communications Biology |
| 4571 | Comparing empirical kinship derived heritability for imaging genetics traits in the UK biobank and human connectome project | Si Gao (+16) | 2021 | NeuroImage |
| 5608 | Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry: a UK Biobank cohort analysis | Daniel H Higbee (+3) | 2021 | The Lancet Respiratory Medicine |
| 10494 | Searching for robust associations with a multi-environment knockoff filter | S Li (+4) | 2021 | Biometrika |
| 4041 | An assessment of the effect of the genotype on postoperative venous thromboembolism risk in 140,831 surgical patients | A Christensen M et al. | 2021 | Ann Med Surg (Lond) |
| 4103 | Assessing the linear and non-linear association of HbA1c with cardiovascular disease: a Mendelian randomisation study | Luo S et al. | 2021 | Diabetologia |
| 4689 | Dietary Patterns Characterized by Fat Type in Association with Obesity and Type 2 Diabetes: A Longitudinal Study of UK Biobank Participants | Barbara Brayner (+5) | 2021 | Journal of Nutrition |
| 4770 | Eight novel susceptibility loci and putative causal variants in atopic dermatitis | Tanaka N et al. | 2021 | J Allergy Clin Immunol |
| 4802 | Evaluating the associations of adult heel BMD with birth weight and growth parameters at age 10 in UK Biobank cohort | Yang X et al. | 2021 | Bone |
| 4849 | Familial factors, diet, and risk of cardiovascular disease: a cohort analysis of the UK Biobank | Hanyue Zhang (+11) | 2021 | American Journal of Clinical Nutrition |
| 5098 | Gut microbiota is associated with bone mineral density : an observational and genome-wide environmental interaction analysis in the UK Biobank cohort | Cheng B et al. | 2021 | Bone Joint Res |
| 5149 | Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort | Sipilä PN et al. | 2021 | Lancet Infect Dis |
| 5191 | Immunofluorescence-guided segmentation of three-dimensional features in micro-computed tomography datasets of human lung tissue | Lawson MJ et al. | 2021 | R Soc Open Sci |
| 5274 | Investigating the causal relationship between allergic disease and mental health | Budu-Aggrey A et al. | 2021 | Clin Exp Allergy |
| 5429 | Multimorbidity and the risk of major adverse kidney events: findings from the UK Biobank cohort | Sullivan MK et al. | 2021 | Clin Kidney J |
| 5594 | Prediction of primary venous thromboembolism based on clinical and genetic factors within the U.K. Biobank | David A. Kolin (+2) | 2021 | Scientific Reports |
| 5637 | Random plasma glucose levels and cause-specific mortality among Chinese adults without known diabetes: an 11-year prospective study of 450,000 people | Vermunt J et al. | 2021 | BMJ Open Diabetes Res Care |
| 5868 | The impact of removing former drinkers from genome-wide association studies of AUDIT-C | Dao C et al. | 2021 | Addiction |
| 10107 | Associations of neighbourhood housing density with loneliness and social isolation: a cross-sectional study using UK Biobank data | Ka Yan Lai (+4) | 2021 | The Lancet |
| 12666 | Calculating a national Anomie Density Ratio: Measuring the patterns of loneliness and social isolation across the UK's residential density gradient using results from the UK Biobank study | Ka Yan Lai (+5) | 2021 | Landscape and Urban Planning |
| 12667 | Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies | Jie Chen (+6) | 2021 | Journal of Bone and Mineral Research |
| 7246 | Association between Cognitive Function and Depression with Human T-Cell Lymphotropic Virus 1 Seropositivity and Serointensity in UK Adults | Lance D. Erickson (+4) | 2021 | Pathogens |
| 3999 | Adverse muscle composition predicts all-cause mortality in the UK Biobank imaging study | Jennifer Linge (+4) | 2021 | Journal of Cachexia Sarcopenia and Muscle |
| 5329 | Lipoprotein(a) and SARS-CoV-2 infections: Susceptibility to infections, ischemic heart disease and thromboembolic events | Silvia Di Maio (+6) | 2021 | Journal of Internal Medicine |
| 10106 | Opposing patterns in self-reported and measured physical activity levels in middle-aged adults | Jin Luo (+1) | 2021 | European Journal of Ageing |
| 4056 | An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci | Edward Mountjoy (+18) | 2021 | Nature Genetics |
| 5157 | Hyperopia Is Not Causally Associated With a Major Deficit in Educational Attainment | Denis Plotnikov (+5) | 2021 | Translational Vision Science & Technology |
| 5382 | Mental health in the UK Biobank: A roadmap to self-report measures and neuroimaging correlates | Rosie K Dutt (+5) | 2021 | Human Brain Mapping |
| 5990 | Visual Impairment and Risk of Dementia in 2 Population-Based Prospective Cohorts: UK Biobank and EPIC-Norfolk | Thomas J Littlejohns (+7) | 2021 | The Journals of Gerontology Series A |
| 10426 | Genome-wide association study of susceptibility to hospitalised respiratory infections | Alexander T. Williams (+45) | 2021 | Wellcome Open Research |
| 4287 | Associations of Diet Quality with Midlife Brain Volume: Findings from the UK Biobank Cohort Study | Macpherson H et al. | 2021 | J Alzheimers Dis |
| 4717 | Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis | Peter Geon Kim (+27) | 2021 | Journal of Experimental Medicine |
| 7247 | Brain structure, psychosocial, and physical health in acute and chronic back pain: a UK Biobank study | Scott D. Tagliaferri (+5) | 2021 | Pain |
| 4830 | Exploiting family history in aggregation unit-based genetic association tests | Yanbing Wang (+4) | 2021 | European Journal of Human Genetics |
| 4876 | GEM: scalable and flexible gene-environment interaction analysis in millions of samples | Westerman KE et al. | 2021 | Bioinformatics |
| 5169 | Identification of novel genome-wide pleiotropic associations with oral inflammatory traits | Yanjiao Jin (+5) | 2021 | Molecular Genetics and Genomics |
| 10425 | A completely automated pipeline for 3D reconstruction of human heart from 2D cine magnetic resonance slices | Abhirup Banerjee (+7) | 2021 | Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences |
| 5513 | Parental Life Span and Polygenic Risk Score of Longevity Are Associated With White Matter Hyperintensities | Chao Dong (+6) | 2021 | The Journals of Gerontology Series A |
| 4832 | Exploration of weighting schemes based on allele frequency and annotation for weighted burden association analysis of complex phenotypes | David Curtis | 2021 | Gene |
| 12668 | Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank | Ruotong Yang (+16) | 2021 | BMC Medicine |
| 5401 | Milk intake and incident stroke and CHD in populations of European descent: a Mendelian randomisation study | L. E. T. Vissers (+37) | 2021 | British Journal Of Nutrition |
| 7248 | Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits | Ruth Johnson (+5) | 2021 | PLOS Computational Biology |
| 10423 | Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics | María Gordillo-Marañón (+20) | 2021 | Nature Communications |
| 12669 | Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID-19 | S. K. Henne (+4) | 2021 | Skin Health and Disease |
| 5313 | Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR | Anna Hutchinson (+3) | 2021 | PLOS Genetics |
| 5392 | Metabolic Syndrome and Risk of Gastrointestinal Cancers: An Investigation Using Large-scale Molecular Data | Rothwell JA et al. | 2021 | Clin Gastroenterol Hepatol |
| 5503 | Optimizing drug selection from a prescription trajectory of one patient | Alejandro Aguayo-Orozco (+6) | 2021 | npj Digital Medicine |
| 5919 | Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease | Zheng J et al. | 2021 | Int J Epidemiol |
| 5931 | Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK | Aliki-Eleni Farmaki (+12) | 2021 | Diabetologia |
| 4236 | Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study | Zhi-Hao Li (+14) | 2021 | European Journal of Endocrinology |
| 10420 | Genetically Predicted Type 2 Diabetes Mellitus Liability, Glycated Hemoglobin and Cardiovascular Diseases: A Wide-Angled Mendelian Randomization Study | Bowen Liu (+5) | 2021 | Genes |
| 4712 | Distinction of lymphoid and myeloid clonal hematopoiesis | Abhishek Niroula (+14) | 2021 | Nature Medicine |
| 4821 | Exome sequencing and analysis of 454,787 UK Biobank participants | Joshua D. Backman (+40) | 2021 | Nature |
| 5224 | Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets | Carla Márquez-Luna (+6) | 2021 | Nature Communications |
| 10416 | Comparing Genetic and Socioenvironmental Contributions to Ethnic Differences in C-Reactive Protein | Shashwat Deepali Nagar (+5) | 2021 | Frontiers in Genetics |
| 12670 | Brain age estimation at tract group level and its association with daily life measures, cardiac risk factors and genetic variants | Ahmed Salih (+9) | 2021 | Scientific Reports |
| 3933 | A probabilistic deep motion model for unsupervised cardiac shape anomaly assessment | Arezoo Zakeri (+4) | 2021 | Medical Image Analysis |
| 4178 | Association of body-shape phenotypes with imaging measures of body composition in the UK Biobank cohort: relevance to colon cancer risk | Sofia Christakoudi (+3) | 2021 | BMC Cancer |
| 5339 | Long-term conditions, multimorbidity, lifestyle factors and change in grip strength over 9 years of follow-up: Findings from 44,315 UK biobank participants | Christopher Hurst (+7) | 2021 | Age and Ageing |
| 5351 | Machine-learning algorithms predict breast cancer patient survival from UK Biobank whole-exome sequencing data | Bum-Sup Jang (+1) | 2021 | Biomarkers in Medicine |
| 5894 | The Significance of Observing the Risk of Non-communicable Diseases after Large-scale Disasters and Communicable Disease Epidemics | Metoki H | 2021 | JMA J |
| 3877 | A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers | John B. Whitfield (+41) | 2021 | Journal of Hepatology |
| 6005 | White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy | Zhenyao Ye (+15) | 2021 | Frontiers in Neuroscience |
| 10414 | Deep Learning for Classification and Selection of Cine CMR Images to Achieve Fully Automated Quality-Controlled CMR Analysis From Scanner to Report | Vittoria Vergani (+3) | 2021 | Frontiers in Cardiovascular Medicine |
| 5583 | Population modeling with machine learning can enhance measures of mental health | Kamalaker Dadi (+5) | 2021 | GigaScience |
| 12671 | Association of mitochondrial DNA copy number with cardiometabolic diseases | Xue Liu (+38) | 2021 | Cell Genomics |
| 4140 | Association between fish oil supplementation and cancer risk according to fatty fish consumption: A large prospective population-based cohort study using UK Biobank | Zheran Liu (+14) | 2021 | International Journal of Cancer |
| 4249 | Associations between alcohol use and accelerated biological ageing | Sunniva M. K. Bøstrand (+13) | 2021 | Addiction Biology |
| 5446 | Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior | Ronald de Vlaming (+6) | 2021 | Communications Biology |
| 3649 | Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures | Julian Mutz (+2) | 2021 | BMC Medicine |
| 4133 | Association between circulating insulin-like growth factor 1 and risk of all-cause and cause-specific mortality | Yu Xie (+7) | 2021 | European Journal of Endocrinology |
| 5310 | Large-scale whole-exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder | Wei Zhou (+8) | 2021 | CNS Neuroscience & Therapeutics |
| 12672 | Phenotypic and Genotypic Associations Between Migraine and Lipoprotein Subfractions | Yanjun Guo (+8) | 2021 | Neurology |
| 12673 | Prevalence and Risk Factors of Cerebral Microbleeds | Dongwei Lu (+4) | 2021 | Neurology |
| 6011 | Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities | Rainer Malik (+11) | 2021 | Brain |
| 7249 | Cortical and Subcortical Brain Volumes Partially Mediate the Association between Dietary Composition and Behavioral Disinhibition: A UK Biobank Study | Daan van Rooij (+4) | 2021 | Nutrients |
| 5747 | Shingles, Zostavax vaccination and risk of developing dementia: a nested case-control study-results from the UK Biobank cohort | Lophatananon A et al. | 2021 | BMJ Open |
| 4158 | Association between polygenic risk for Alzheimer's disease, brain structure and cognitive abilities in UK Biobank | Rachana Tank (+6) | 2021 | Neuropsychopharmacology |
| 4697 | Diphtheria And Tetanus Vaccination History Is Associated With Lower Odds of COVID-19 Hospitalization | Monereo-Sánchez J et al. | 2021 | Front Immunol |
| 5126 | Hepatobiliary phenotype of individuals with chronic intestinal disorders | Jessica Voss (+5) | 2021 | Scientific Reports |
| 5136 | High serum uric acid may associate with the increased risk of colorectal cancer in females: A prospective cohort study | Ningning Mi (+18) | 2021 | International Journal of Cancer |
| 7250 | Is psychosis a syndemic manifestation of historical and contemporary adversity? Findings from UK Biobank | Kamaldeep Bhui (+3) | 2021 | The British Journal of Psychiatry |
| 10412 | Metabolic syndrome and its component traits present gender-specific association with liver cancer risk: a prospective cohort study | Bin Xia (+13) | 2021 | BMC Cancer |
| 10413 | A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo | Astros Th. Skuladottir (+30) | 2021 | Communications Biology |
| 5045 | Genome-wide association study of occupational attainment as a proxy for cognitive reserve | Hyunwoong Ko (+18) | 2021 | Brain |
| 7620 | Calibrated rare variant genetic risk scores for complex disease prediction using large exome sequence repositories | Ricky Lali (+6) | 2021 | Nature Communications |
| 3946 | A sex-specific evolutionary interaction between ADCY9 and CETP | Gamache I et al. | 2021 | Elife |
| 5562 | Polygenic basis and biomedical consequences of telomere length variation | Veryan Codd (+27) | 2021 | Nature Genetics |
| 10409 | Genetic and phenotypic analysis of the causal relationship between aging and COVID-19 | Kejun Ying (+7) | 2021 | Communications Medicine |
| 10410 | Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis | Jing Yang (+7) | 2021 | Frontiers in Genetics |
| 10411 | A sex-specific evolutionary interaction between ADCY9 and CETP | Isabel Gamache (+15) | 2021 | eLife |
| 4947 | Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia | Plotnikov D et al. | 2021 | Invest Ophthalmol Vis Sci |
| 5511 | Panoramic smoking burden and genetic susceptibility in relation to all-cause and cause-specific mortality: a prospective study in UK Biobank | Song Q et al. | 2021 | Addiction |
| 7251 | The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank | Xianwen Shang (+6) | 2021 | Hypertension |
| 10408 | Selection of 51 predictors from 13,782 candidate multimodal features using machine learning improves coronary artery disease prediction | Saaket Agrawal (+9) | 2021 | Patterns |
| 4019 | Air Pollution, Genetic Factors, and the Risk of Lung Cancer: A Prospective Study in the UK Biobank. | Yanqian Huang (+16) | 2021 | American Journal of Respiratory and Critical Care Medicine |
| 4171 | Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank | Wainberg M et al. | 2021 | PLoS Med |
| 4230 | Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants | Petermann-Rocha F et al. | 2021 | J Cachexia Sarcopenia Muscle |
| 4457 | Causal relationships between blood lipids and depression phenotypes: a Mendelian randomisation analysis | So HC et al. | 2021 | Psychol Med |
| 4566 | Commute patterns, residential traffic-related air pollution, and lung cancer risk in the prospective UK Biobank cohort study | Wong JYY et al. | 2021 | Environ Int |
| 4831 | Exploration of Sleep as a Specific Risk Factor for Poor Metabolic and Mental Health: A UK Biobank Study of 84,404 Participants | Gewei Zhu (+8) | 2021 | Nature and Science of Sleep |
| 4871 | Functional reciprocity of proteins involved in mitosis and endocytosis | Yu H et al. | 2021 | FEBS J |
| 5295 | Kidney damage causally affects the brain cortical structure: A Mendelian randomization study | Chen X et al. | 2021 | EBioMedicine |
| 5371 | Mendelian randomisation study of smoking exposure in relation to breast cancer risk | Park HA et al. | 2021 | Br J Cancer |
| 5452 | Neuroanatomical norms in the UK Biobank: The impact of allometric scaling, sex, and age | Williams CM et al. | 2021 | Hum Brain Mapp |
| 5596 | Predictive Accuracy of a Clinical and Genetic Risk Model for Atrial Fibrillation | Khurshid S et al. | 2021 | Circ Genom Precis Med |
| 7334 | Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study | G David Batty (+1) | 2021 | Clinical Epidemiology |
| 10407 | Controlling for background genetic effects using polygenic scores improves the power of genome-wide association studies | Declan Bennett (+4) | 2021 | Scientific Reports |
| 3865 | A cross-population atlas of genetic associations for 220 human phenotypes | Saori Sakaue (+45) | 2021 | Nature Genetics |
| 4078 | APOE, TOMM40, and sex interactions on neural network connectivity | Tianqi Li (+12) | 2021 | Neurobiology of Aging |
| 5420 | MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent | Longman Li (+12) | 2021 | iScience |
| 5427 | Multimorbid disease trajectories for people with periodontitis | Harriet Larvin (+4) | 2021 | Journal Of Clinical Periodontology |
| 5941 | Uncovering Clinical Risk Factors and Predicting Severe COVID-19 Cases Using UK Biobank Data: Machine Learning Approach | Kenneth Chi-Yin Wong (+3) | 2021 | JMIR Public Health and Surveillance |
| 10404 | Association between migraine prevalence, treatment with proton-pump inhibitors and CYP2C19 phenotypes in UK Biobank | Claudia Pisanu (+4) | 2021 | Biomedicine & Pharmacotherapy |
| 4656 | Detecting retinal neurodegeneration in people with diabetes: Findings from the UK Biobank | Channa R et al. | 2021 | PLoS One |
| 4827 | Explaining Ethnic Differentials in COVID-19 Mortality: A Cohort Study | G David Batty (+4) | 2021 | American Journal of Epidemiology |
| 5642 | Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function | Tianzhong Yang (+46) | 2021 | Scientific Reports |
| 12674 | Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia | April C.E. van Gennip (+15) | 2021 | Diabetes Care |
| 3919 | A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population | Rostalski H et al. | 2021 | J Alzheimers Dis |
| 4414 | Cardiometabolic Health Outcomes Associated With Discordant Visceral and Liver Fat Phenotypes: Insights From the Dallas Heart Study and UK Biobank | Sanaa Tejani (+9) | 2021 | Mayo Clinic Proceedings |
| 4848 | False discovery rate control in genome-wide association studies with population structure | Matteo Sesia (+4) | 2021 | Proceedings of the National Academy of Sciences of the United States of America |
| 5265 | Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment | Laurence J Howe (+3) | 2021 | International Journal of Epidemiology |
| 7437 | Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use | Sarah M. C. Colbert (+7) | 2021 | American Journal of Medical Genetics Part B Neuropsychiatric Genetics |
| 4099 | Assessing the Causal Relationships Between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization | Natalie McCormick (+6) | 2021 | Arthritis & Rheumatology |
| 5661 | Relationship Between Rheumatoid Arthritis and Pulmonary Function Measures on Spirometry in the UK Biobank | Lauren Prisco (+11) | 2021 | Arthritis & Rheumatology |
| 5230 | Independent effects of adiposity measures on risk of atrial fibrillation in men and women: a study of 0.5 million individuals | Camm CF et al. | 2021 | Int J Epidemiol |
| 7252 | Frailty Phenotype and Mortality: A Prospective Cohort Study | Yabing Hou (+8) | 2021 | Journal of the American Medical Directors Association |
| 3937 | A prospective study of inflammatory biomarkers and growth factors and risk of glioma in the UK Biobank | David J Cote (+6) | 2021 | Cancer Epidemiology |
| 4222 | Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization | Ma Cherrysse Ulsa (+10) | 2021 | The Journals of Gerontology Series A |
| 5404 | Mitochondrial Genomes, Phylogenetic Associations, and SNP Recovery for the Key Invasive Ponto-Caspian Amphipods in Europe | Mamos T et al. | 2021 | Int J Mol Sci |
| 10401 | Vitamin D and the Risks of Depression and Anxiety: An Observational Analysis and Genome-Wide Environment Interaction Study | Zhen Zhang (+11) | 2021 | Nutrients |
| 4233 | Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease | Lei Dai (+2) | 2021 | Frontiers in Nutrition |
| 5460 | New Imaging Signatures of Cardiac Alterations in Ischaemic Heart Disease and Cerebrovascular Disease Using CMR Radiomics | Elisa Rauseo (+6) | 2021 | Frontiers in Cardiovascular Medicine |
| 5940 | Uncertainty-aware body composition analysis with deep regression ensembles on UK Biobank MRI | Taro Langner (+5) | 2021 | Computerized Medical Imaging and Graphics |
| 7253 | Discovery and implications of polygenicity of common diseases | Peter M Visscher (+3) | 2021 | Science |
| 7337 | Protein-coding repeat polymorphisms strongly shape diverse human phenotypes | Ronen E Mukamel (+6) | 2021 | Science |
| 7621 | Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls | Emma Corley (+5) | 2021 | Translational Psychiatry |
| 3878 | A genetic risk score using human chromosomal-scale length variation can predict schizophrenia | Christopher Toh (+1) | 2021 | Scientific Reports |
| 4206 | Association of lichen planus with cardiovascular disease: A combined analysis of the UK Biobank and All of Us Study | Audrey C Leasure (+5) | 2021 | Journal of the American Academy of Dermatology |
| 10398 | Age at Natural Menopause and Blood Pressure Traits: Mendelian Randomization Study | Zayne M. Roa-Díaz (+11) | 2021 | Journal of Clinical Medicine |
| 10399 | LTA4H rs2660845 association with montelukast response in early and late-onset asthma | Cyrielle Maroteau (+17) | 2021 | PLOS ONE |
| 5988 | Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology | Alexey A Shadrin (+21) | 2021 | NeuroImage |
| 10397 | Fine mapping of the HLA locus in Parkinson's disease in Europeans | Eric Yu (+18) | 2021 | npj Parkinson's Disease |
| 4764 | Effects of Within-Person Variability in Spot Urinary Sodium Measurements on Associations With Blood Pressure and Cardiovascular Disease | Federica Re (+6) | 2021 | Hypertension |
| 5974 | Validation and public health modelling of risk prediction models for kidney cancer using the UK Biobank | Harrison H et al. | 2021 | BJU Int |
| 4001 | Age and sex effects on advanced white matter microstructure measures in 15,628 older adults: A UK biobank study | Katherine E. Lawrence (+12) | 2021 | Brain Imaging and Behavior |
| 4833 | Exploring Drugs and Vaccines Associated with Altered Risks and Severity of COVID-19: A UK Biobank Cohort Study of All ATC Level-4 Drug Categories Reveals Repositioning Opportunities | Yong Xiang (+2) | 2021 | Pharmaceutics |
| 3343 | GenNet framework: interpretable deep learning for predicting phenotypes from genetic data | Arno van Hilten (+7) | 2021 | Communications Biology |
| 5088 | Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study | Xi-Ru Zhang (+16) | 2021 | British Journal Of Nutrition |
| 7444 | On cross-ancestry cancer polygenic risk scores | Lars G. Fritsche (+6) | 2021 | PLOS Genetics |
| 8186 | GWAS Identifies Three Susceptibility Loci for Trichilemmal Cysts | Ahmed Yousaf (+1) | 2021 | Journal of Investigative Dermatology |
| 12675 | Is asthma associated with COVID-19 infection? A UK Biobank analysis | Caroline J. Lodge (+7) | 2021 | ERJ Open Research |
| 3960 | Ability of known colorectal cancer susceptibility SNPs to predict colorectal cancer risk: A cohort study within the UK Biobank | Aviv Gafni (+4) | 2021 | PLOS ONE |
| 4219 | Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants | Lousise A. C. Millard (+4) | 2021 | PLOS Medicine |
| 9618 | Whole-milk consumption decreases the risk of inflammatory bowel disease: a two-sample Mendelian randomization analysis | Jiuling Li (+10) | 2021 | Journal of Bio-X Research |
| 4055 | An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank | Xue Li (+10) | 2021 | Scientific Reports |
| 4786 | Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data | Nicole M. Warrington (+3) | 2021 | Nature Communications |
| 5184 | Identifying the lungs as a susceptible site for allele-specific regulatory changes associated with type 1 diabetes risk | Daniel Ho (+8) | 2021 | Communications Biology |
| 5484 | Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer | Chong Wu (+17) | 2021 | Cancer Communications |
| 7445 | Biomarkers of kidney function and cognitive ability: A Mendelian randomization study | Erin L Richard (+6) | 2021 | Journal of the Neurological Sciences |
| 10268 | Derandomizing Knockoffs | Zhimei Ren (+2) | 2021 | Journal of the American Statistical Association |
| 4587 | Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape | Jonathan Sulc (+10) | 2021 | Communications Biology |
| 4933 | Genetic predisposition to tinnitus in the UK Biobank population | Madeleine E. Urbanek (+1) | 2021 | Scientific Reports |
| 5906 | Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank | Nicolien A van Vliet (+6) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 7602 | Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank | Xianwen Shang (+8) | 2021 | British Journal of Ophthalmology |
| 7622 | Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis | Alexander G Thompson (+2) | 2021 | Journal of Neurology Neurosurgery & Psychiatry |
| 12920 | Rare genetic coding variants associated with human longevity and protection against age-related diseases | Jhih-Rong Lin (+26) | 2021 | Nature Aging |
| 4491 | Circulating C-reactive protein increases lung cancer risk: Results from a prospective cohort of UK Biobank | Mengmeng Ji (+17) | 2021 | International Journal of Cancer |
| 7446 | Genome-wide methylation data improves dissection of the effect of smoking on body mass index | Carmen Amador (+11) | 2021 | PLOS Genetics |
| 10267 | Shape registration with learned deformations for 3D shape reconstruction from sparse and incomplete point clouds | Xiang Chen (+8) | 2021 | Medical Image Analysis |
| 5443 | Multi-Trait Genomic Risk Stratification for Type 2 Diabetes | Palle Duun Rohde (+3) | 2021 | Frontiers in Medicine |
| 5897 | The Triangulation WIthin a STudy (TWIST) framework for causal inference within pharmacogenetic research | Jack Bowden (+4) | 2021 | PLOS Genetics |
| 4435 | Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank | Ai S et al. | 2021 | Eur Heart J |
| 5644 | Rare GATA6 variants associated with risk of congenital heart disease phenotypes in 200,000 UK Biobank exomes | Simon G. Williams (+2) | 2021 | Journal of Human Genetics |
| 5718 | Sex differences in genetic architecture in the UK Biobank | Elena Bernabeu (+5) | 2021 | Nature Genetics |
| 5649 | Reallocation of time between device-measured movement behaviours and risk of incident cardiovascular disease | Rosemary Walmsley (+8) | 2021 | British Journal of Sports Medicine |
| 10044 | Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction | Jiangming Sun (+12) | 2021 | Nature Communications |
| 12676 | Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative | Amarise Little (+67) | 2021 | Human Molecular Genetics |
| 4100 | Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression | Yujing Chen (+12) | 2021 | Molecular Brain |
| 5519 | Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K. | Yogini V. Chudasama (+11) | 2021 | BMC Infectious Diseases |
| 4615 | COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases | Areti Papadopoulou (+5) | 2021 | PLOS ONE |
| 5858 | The genetics of testosterone contributes to "femaleness/maleness" of cardiometabolic traits and type 2 diabetes | Daniel E. Vosberg (+4) | 2021 | International Journal of Obesity |
| 4853 | Fast two-stage phasing of large-scale sequence data | Brian L Browning (+3) | 2021 | American Journal of Human Genetics |
| 5381 | Mental Health as a Mediator of the Association Between Educational Inequality and Cardiovascular Disease: A Mendelian Randomization Study | Daniel P. Jones (+6) | 2021 | Journal of the American Heart Association |
| 5773 | Spectral clustering based on structural magnetic resonance imaging and its relationship with major depressive disorder and cognitive ability | Wah Yeung (+18) | 2021 | European Journal of Neuroscience |
| 4061 | Analysis of 200,000 Exome-Sequenced UK Biobank Subjects Implicates Genes Involved in Increased and Decreased Risk of Hypertension | Curtis D | 2021 | Pulse (Basel) |
| 4064 | Analysis of Diffusion Tensor Imaging Data From the UK Biobank Confirms Dosage Effect of 15q11.2 Copy Number Variation on White Matter and Shows Association With Cognition | Silva AI et al. | 2021 | Biol Psychiatry |
| 4188 | Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events | Bhattacharya R et al. | 2021 | JAMA Cardiol |
| 4210 | Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma | Siggs OM et al. | 2021 | JAMA Ophthalmol |
| 4269 | Associations between physical multimorbidity patterns and common mental health disorders in middle-aged adults: A prospective analysis using data from the UK Biobank | Ronaldson A et al. | 2021 | Lancet Reg Health Eur |
| 4363 | Birth weight, childhood obesity and risk of hypertension: a Mendelian randomization study | Fan J et al. | 2021 | J Hypertens |
| 4365 | Block coordinate descent algorithm improves variable selection and estimation in error-in-variables regression | Célia Escribe (+8) | 2021 | Genetic Epidemiology |
| 4463 | Cervical screening attendance and cervical cancer risk among women who have sex with women | Saunders CL et al. | 2021 | J Med Screen |
| 4471 | Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank | Zebardast N et al. | 2021 | Ophthalmology |
| 4527 | Coffee Consumption and Incident Tachyarrhythmias: Reported Behavior, Mendelian Randomization, and Their Interactions | Kim EJ et al. | 2021 | JAMA Intern Med |
| 4775 | Self-reported medication use as an alternate phenotyping method for anxiety and depression in the UK Biobank | Megan Skelton (+9) | 2021 | American Journal of Medical Genetics Part B Neuropsychiatric Genetics |
| 4893 | Genetic architecture of four smoking behaviors using partitioned SNP heritability | Evans LM et al. | 2021 | Addiction |
| 4897 | Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness | Cheng W et al. | 2021 | JAMA Psychiatry |
| 5112 | Habitual use of fish oil supplements, genetic predisposition, and risk of fractures: a large population-based study | Zhendong Mei (+9) | 2021 | American Journal of Clinical Nutrition |
| 5168 | Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort | Tamara Ashvetiya (+6) | 2021 | PLOS ONE |
| 5242 | Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort | Chu X et al. | 2021 | Sleep Med |
| 5359 | Measurement invariance testing of the patient health questionnaire-9 (PHQ-9) across people with and without diabetes mellitus from the NHANES, EMHS and UK Biobank datasets | Nouwen A et al. | 2021 | J Affect Disord |
| 5496 | Observed evidence for guideline-recommended genes in predicting prostate cancer risk from a large population-based cohort | Wei J et al. | 2021 | Prostate |
| 5563 | Polygenic burden could explain high rates of affective disorders in a community with restricted founder population | Xiaotong Wang (+5) | 2021 | American Journal of Medical Genetics Part B Neuropsychiatric Genetics |
| 5727 | Sex specific effect of gut microbiota on the risk of psychiatric disorders: A Mendelian randomisation study and PRS analysis using UK Biobank cohort | Qi X et al. | 2021 | World J Biol Psychiatry |
| 5984 | Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank | Sandoval-Plata G et al. | 2021 | Ann Rheum Dis |
| 7448 | Human genetic analyses of organelles highlight the nucleus in age-related trait heritability | Rahul Gupta (+4) | 2021 | eLife |
| 7449 | The oxytocin signalling gene pathway contributes to the association between loneliness and cardiometabolic health | A. Winterton (+8) | 2021 | Psychoneuroendocrinology |
| 10043 | Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophrenia | Gudrun A. Jonsdottir (+28) | 2021 | Intelligence |
| 10224 | Mendelian randomization to investigate the link between TSH and thyroid cancer | Jonathan M Fussey (+5) | 2021 | Endocrine Related Cancer |
| 12677 | Healthy Sleep Patterns and Risk of Incident Arrhythmias | Xiang Li (+6) | 2021 | Journal of the American College of Cardiology |
| 4910 | Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia | Linda Kachuri (+8) | 2021 | American Journal of Human Genetics |
| 5017 | Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse | Mengyao Yu (+10) | 2021 | Circulation Genomic and Precision Medicine |
| 5972 | Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment | Haoyu Wu (+8) | 2021 | Circulation Genomic and Precision Medicine |
| 10042 | Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study | João Fadista (+17) | 2021 | Scientific Reports |
| 5096 | Grey and white matter microstructure is associated with polygenic risk for schizophrenia | Eva-Maria Stauffer (+6) | 2021 | Molecular Psychiatry |
| 12678 | Examining the Relationship between Toxoplasma gondii and Seropositivity and Serointensity and Depression in Adults from the United Kingdom and the United States: A Cross-Sectional Study | Shawn D. Gale (+3) | 2021 | Pathogens |
| 4792 | Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank | Hannah Higgins (+5) | 2021 | Journal of the American Heart Association |
| 3987 | Adiposity and cancer: a Mendelian randomization analysis in the UK biobank | Muktar Ahmed (+5) | 2021 | International Journal of Obesity |
| 5908 | Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants | Angus C Burns (+5) | 2021 | Journal of Affective Disorders |
| 5950 | Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis | Sliz E et al. | 2021 | J Allergy Clin Immunol |
| 10041 | An analysis of frailty and multimorbidity in 20,566 UK Biobank participants with type 2 diabetes | Peter Hanlon (+6) | 2021 | Communications Medicine |
| 12679 | Re-Calibrating Pure Risk Integrating Individual Data from Two-Phase Studies with External Summary Statistics | Jiayin Zheng (+2) | 2021 | Biometrics |
| 4157 | Association between polygenic propensity for psychiatric disorders and nutrient intake | Avina K. Hunjan (+4) | 2021 | Communications Biology |
| 5864 | The impact of age on genetic risk for common diseases | Xilin Jiang (+2) | 2021 | PLOS Genetics |
| 7298 | Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression | Angela Mo (+40) | 2021 | American Journal of Human Genetics |
| 10223 | Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | Cindy G. Boer (+158) | 2021 | Cell |
| 3889 | A genome-wide association study of the frailty index highlights brain pathways in ageing | Janice L. Atkins (+9) | 2021 | Aging Cell |
| 4750 | Effect of Diet Quality and Genetic Predisposition on Hemoglobin A1c and Type 2 Diabetes Risk: Gene-Diet Interaction Analysis of 357,419 Individuals. | Pan Zhuang (+7) | 2021 | Diabetes Care |
| 7450 | Hierarchical modelling of functional brain networks in population and individuals from big fMRI data | Seyedeh-Rezvan Farahibozorg (+6) | 2021 | NeuroImage |
| 10222 | Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease | Zong Miao (+8) | 2021 | Human Genetics and Genomics Advances |
| 7623 | Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits | Jordi Merino (+19) | 2021 | Nature Human Behaviour |
| 10219 | Genomic evidence consistent with antagonistic pleiotropy may help explain the evolutionary maintenance of same-sex sexual behaviour in humans | Brendan P. Zietsch (+9) | 2021 | Nature Human Behaviour |
| 10220 | Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region | Nicholas Bowker (+14) | 2021 | Diabetes |
| 10221 | Linking common human diseases to their phenotypes; development of a resource for human phenomics | Şenay Kafkas (+4) | 2021 | Journal of Biomedical Semantics |
| 12680 | Association of coffee and genetic risk with incident dementia in middle-aged and elderly adults | Yuan Zhang (+6) | 2021 | Nutritional Neuroscience |
| 4090 | Assessing causal associations of obesity and diabetes with kidney stones using Mendelian randomization analysis | Yuan S et al. | 2021 | Mol Genet Metab |
| 12681 | Visual Impairment and Risk of Dementia: The UK Biobank Study | Zhuoting Zhu (+13) | 2021 | American Journal of Ophthalmology |
| 10218 | No evidence that HLA genotype influences the driver mutations that occur in cancer patients | Noor Kherreh (+2) | 2021 | Cancer Immunology, Immunotherapy |
| 4122 | Association and pathways between shift work and cardiovascular disease: a prospective cohort study of 238 661 participants from UK Biobank | Frederick K Ho (+8) | 2021 | International Journal of Epidemiology |
| 4404 | Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank | B.G. Faber (+10) | 2021 | Osteoarthritis and Cartilage |
| 5923 | Traumatic events during childhood and its risks to substance use in adulthood: an observational and genome-wide by environment interaction study in UK Biobank | Shiqiang Cheng (+10) | 2021 | Translational Psychiatry |
| 4521 | Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease | Ahmed A. Z. Dawoud (+3) | 2021 | Leukemia |
| 5350 | Machine learning approach to dynamic risk modeling of mortality in COVID-19: a UK Biobank study | Mohammad A. Dabbah (+11) | 2021 | Scientific Reports |
| 5438 | Multi-scale inference of genetic trait architecture using biologically annotated neural networks | Pinar Demetci (+5) | 2021 | PLOS Genetics |
| 7451 | UKB.COVID19: an R package for UK Biobank COVID-19 data processing and analysis | Longfei Wang (+3) | 2021 | F1000Research |
| 4477 | Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank | Julia Höglund (+4) | 2021 | American Journal of Hematology |
| 4867 | FTO Obesity Variant-Exercise Interaction on Changes in Body Weight and BMI: The Taiwan Biobank Study | Hiraike Y et al. | 2021 | J Clin Endocrinol Metab |
| 5716 | Sex Differences in Association Between Anti-Hypertensive Medications and Risk of COVID-19 in Middle-Aged and Older Adults | Yue Ma (+8) | 2021 | Drugs & Aging |
| 12682 | Ovarian cancer risk in relation to blood cholesterol and triglycerides | Britton Trabert (+7) | 2021 | Cancer Epidemiology Biomarkers & Prevention |
| 7452 | Chronotype preference and glycemic control in type 2 diabetes | Pei Xue (+3) | 2021 | Sleep |
| 5728 | Sex-specific associations between alcohol consumption, cardiac morphology, and function as assessed by magnetic resonance imaging: insights form the UK Biobank Population Study | Simon J et al. | 2021 | Eur Heart J Cardiovasc Imaging |
| 4147 | Association Between Insomnia and Migraine Risk: A Case-Control and Bidirectional Mendelian Randomization Study | Chu S et al. | 2021 | Pharmgenomics Pers Med |
| 10217 | Development of Digitally Obtainable 10-Year Risk Scores for Depression and Anxiety in the General Population | Davide Morelli (+4) | 2021 | Frontiers in Psychiatry |
| 12683 | Positive predictive value highlights four novel candidates for actionable genetic screening from analysis of 220,000 clinicogenomic records | Kelly M. Schiabor Barrett (+11) | 2021 | Genetics in Medicine |
| 5365 | Medical image segmentation automatic quality control: A multi-dimensional approach | Joris Fournel (+9) | 2021 | Medical Image Analysis |
| 7453 | Greenness and eosinophilic asthma: findings from the UK Biobank | Mingyang Wu (+3) | 2021 | European Respiratory Journal |
| 3949 | A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross-disease analyses | Koldo Garcia-Etxebarria (+14) | 2021 | Neurogastroenterology & Motility |
| 4028 | Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study | Joanna Lankester (+3) | 2021 | PLOS ONE |
| 4057 | Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies | Quan Sun (+18) | 2021 | Journal of Human Genetics |
| 5082 | Geographical heterogeneity across England in associations between the neighbourhood built environment and body mass index | Kate E Mason (+2) | 2021 | Health & Place |
| 5165 | Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank | J. Wei (+9) | 2021 | Hernia |
| 5341 | Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease | Ningjian Wang (+11) | 2021 | European Heart Journal |
| 5647 | Rare variant contribution to human disease in 281,104 UK Biobank exomes | Quanli Wang (+18) | 2021 | Nature |
| 4829 | Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data | Ciarrah Barry (+6) | 2021 | PLOS Genetics |
| 5599 | Preexisting Mental Disorders Increase the Risk of COVID-19 Infection and Associated Mortality | Yongjun Wang (+5) | 2021 | Frontiers in Public Health |
| 12684 | False positive findings during genome-wide association studies with imputation: influence of allele frequency and imputation accuracy | Zhihui Zhang (+4) | 2021 | Human Molecular Genetics |
| 5203 | Impact of Persisting Amblyopia on Socioeconomic, Health, and Well-Being Outcomes in Adult Life: Findings From the UK Biobank | Vasiliki Bountziouka (+2) | 2021 | Value in Health |
| 5803 | The antagonistic pleiotropy of insulin-like growth factor 1 | William B. Zhang (+3) | 2021 | Aging Cell |
| 3929 | A polygenic-score-based approach for identification of gene-drug interactions stratifying breast cancer risk | Andrew R Marderstein (+5) | 2021 | American Journal of Human Genetics |
| 5802 | Testosterone, sex hormone-binding globulin, insulin-like growth factor-1 and endometrial cancer risk: observational and Mendelian randomization analyses | Amy Mullee (+5) | 2021 | British Journal of Cancer |
| 5822 | The BS variant of C4 protects against age-related loss of white matter microstructural integrity | Matthew Traylor (+3) | 2021 | Brain |
| 7254 | Ethnic differences in prevalence of actionable HbA1c levels in UK Biobank: implications for screening | Jana J Anderson (+16) | 2021 | BMJ Open Diabetes Research & Care |
| 7256 | Nonlinear Associations Between Cumulative Dietary Risk Factors and Cardiovascular Diseases, Cancer, and All-Cause Mortality: A Prospective Cohort Study From UK Biobank | Fanny Petermann-Rocha (+8) | 2021 | Mayo Clinic Proceedings |
| 7599 | Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study | Jirapitcha Boonpor (+10) | 2021 | BMJ Open Diabetes Research & Care |
| 4923 | Genetic insights into biological mechanisms governing human ovarian ageing | Katherine S. Ruth (+267) | 2021 | Nature |
| 5614 | Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study | Ann-Marie G de Lange (+6) | 2021 | Behavioural Brain Research |
| 10039 | Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma | Davide G. Berta (+26) | 2021 | Nature |
| 4418 | Cardiovascular and Kidney Outcomes Across the Glycemic Spectrum: Insights From the UK Biobank | Honigberg MC et al. | 2021 | J Am Coll Cardiol |
| 4866 | Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease | Schachtl-Riess JF et al. | 2021 | J Am Coll Cardiol |
| 5967 | Using normative modelling to detect disease progression in mild cognitive impairment and Alzheimer's disease in a cross-sectional multi-cohort study | Walter H. L. Pinaya (+11) | 2021 | Scientific Reports |
| 10038 | Assessing the linear and non-linear association of HbA1c with cardiovascular disease: a Mendelian randomisation study | Shan Luo (+2) | 2021 | Diabetologia |
| 3983 | Adherence to a healthy sleep pattern is associated with lower risks of all-cause, cardiovascular and cancer-specific mortality | Tao Zhou (+7) | 2021 | Journal of Internal Medicine |
| 10028 | Genetic and Physiological Effects of Insulin on Human Urate Homeostasis | Asim K. Mandal (+5) | 2021 | Frontiers in Physiology |
| 10029 | Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes | David Z. Pan (+20) | 2021 | Genome Medicine |
| 3427 | Causal effects of education on chronic kidney disease: a Mendelian randomization study | Park S et al. | 2021 | Clin Kidney J |
| 4108 | Assessing the Relationship Between Serum Urate and Urolithiasis Using Mendelian Randomization: An Analysis of the UK Biobank | Narang RK et al. | 2021 | Am J Kidney Dis |
| 4515 | Clinical Conditions and Their Impact on Utility of Genetic Scores for Prediction of Acute Coronary Syndrome | Lee J et al. | 2021 | Circ Genom Precis Med |
| 5297 | Kidney function and cancer risk: An analysis using creatinine and cystatin C in a cohort study | Lees JS et al. | 2021 | EClinicalMedicine |
| 5340 | Long-term cost-effectiveness of interventions for obesity: A mendelian randomisation study | Harrison S et al. | 2021 | PLoS Med |
| 5357 | Maternal smoking during pregnancy and risks to depression and anxiety in offspring: An observational study and genome-wide gene-environment interaction analysis in UK biobank cohort | Chu X et al. | 2021 | J Psychiatr Res |
| 5455 | Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis | Terracciano A et al. | 2021 | Mov Disord |
| 5472 | Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study | Drozd M et al. | 2021 | Lancet Infect Dis |
| 5487 | Obesity and the relation between joint exposure to ambient air pollutants and incident type 2 diabetes: A cohort study in UK Biobank | Li X et al. | 2021 | PLoS Med |
| 5749 | Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank | Wang Q et al. | 2021 | EBioMedicine |
| 5789 | Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias | Hikino K et al. | 2021 | EBioMedicine |
| 5805 | The association between citrus consumption and melanoma risk in the UK Biobank | Marley AR et al. | 2021 | Br J Dermatol |
| 5909 | Time spent outdoors and risk of myocardial infarction and stroke in middle and old aged adults: Results from the UK Biobank prospective cohort | Miguet M et al. | 2021 | Environ Res |
| 7454 | Automatic segmentation of left and right ventricles in cardiac MRI using 3D-ASM and deep learning | Huaifei Hu (+6) | 2021 | Signal Processing Image Communication |
| 7455 | Genetic predisposition, lifestyle risk, and obesity associate with the progression of nonalcoholic fatty liver disease | Zhenqiu Liu (+6) | 2021 | Digestive and Liver Disease |
| 9625 | Heterozygosity of the Alpha 1-Antitrypsin Pi*Z Allele and Risk of Liver Disease | Aaron Hakim (+9) | 2021 | Hepatology Communications |
| 5238 | Influence of Diabetes Duration and Glycemic Control on Dementia: A Cohort Study | Fu-Rong Li (+9) | 2021 | The Journals of Gerontology Series A |
| 12685 | Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology | Olivia Burt (+9) | 2021 | Genes |
| 3910 | A Mendelian randomization study found causal linkage between telomere attrition and chronic kidney disease | Sehoon Park (+12) | 2021 | Kidney International |
| 4506 | Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study | Yuanqing Fu (+7) | 2021 | BMC Medicine |
| 5973 | Validation and comparison of 28 risk prediction models for coronary artery disease | Lenselink C et al. | 2021 | Eur J Prev Cardiol |
| 12686 | Minor Allele Frequencies and Molecular Pathways Differences for SNPs Associated with Amyotrophic Lateral Sclerosis in Subjects Participating in the UKBB and 1000 Genomes Project | Salvatore D'Antona (+3) | 2021 | Journal of Clinical Medicine |
| 4385 | Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study | Mathew Vithayathil (+5) | 2021 | PLOS Medicine |
| 4453 | Causal linkage between adult height and kidney function: An integrated population-scale observational analysis and Mendelian randomization study | Sehoon Park (+13) | 2021 | PLOS ONE |
| 5084 | GESLM algorithm for detecting causal SNPs in GWAS with multiple phenotypes | Ruiqi Lyu (+5) | 2021 | Briefings in Bioinformatics |
| 12687 | Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment | Siqi Wang (+8) | 2021 | Genes |
| 12688 | Relationship between glucosamine use and the risk of lung cancer: data from a nationwide prospective cohort study. | Guowei Li (+7) | 2021 | European Respiratory Journal |
| 3797 | Genetically Predicted Insomnia in Relation to 14 Cardiovascular Conditions and 17 Cardiometabolic Risk Factors: A Mendelian Randomization Study | Xinhui Liu (+10) | 2021 | Journal of the American Heart Association |
| 4417 | Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes | Tomas I. Gonzales (+8) | 2021 | Scientific Reports |
| 5643 | Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes | Seung Hoan Choi (+49) | 2021 | Circulation Genomic and Precision Medicine |
| 7456 | Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank | Sean Harrison (+3) | 2021 | Science Advances |
| 10027 | Genetic Risk for Overall Cancer and the Benefit of Adherence to a Healthy Lifestyle | Meng Zhu (+15) | 2021 | Cancer Research |
| 12689 | A comprehensive analysis of copy number variation in a Turkish dementia cohort | Nadia Dehghani (+11) | 2021 | Human Genomics |
| 3796 | Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study | Si S et al. | 2021 | Front Immunol |
| 4109 | Assessing the role of cortisol in cancer: a wide-ranged Mendelian randomisation study | Susanna C. Larsson (+4) | 2021 | British Journal of Cancer |
| 4679 | Diet Quality and the Risk of Impaired Speech Reception Threshold in Noise: The UK Biobank cohort | Yévenes-Briones H et al. | 2021 | Ear Hear |
| 7255 | Diet, Sleep, and Mental Health: Insights from the UK Biobank Study | Piril Hepsomali (+1) | 2021 | Nutrients |
| 7457 | Analysis of COVID-19 genetic risk susceptibility using UK Biobank SNP genotype data | Taewan Goo (+3) | 2021 | International Journal of Data Mining and Bioinformatics |
| 9776 | Is occupational physical activity associated with mortality in UK Biobank? | Matthew Pearce (+5) | 2021 | International Journal of Behavioral Nutrition and Physical Activity |
| 9777 | GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms | Goncalo Abecasis (+48) | 2021 | Nature Communications |
| 9778 | Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women | Chengyi Ding (+4) | 2021 | BMC Medicine |
| 4454 | Causal Relationship Between Parathyroid Hormone and the Risk of Osteoarthritis: A Mendelian Randomization Study | Huang G et al. | 2021 | Front Genet |
| 7381 | A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics | Geyu Zhou (+1) | 2021 | PLOS Genetics |
| 8187 | A discarded synonymous variant in NPHP3 explains nephronophthisis and congenital hepatic fibrosis in several families | Eric Olinger (+17) | 2021 | Human Mutation |
| 12690 | Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men | Alexander M. Kulminski (+4) | 2021 | Alzheimer's & Dementia |
| 5132 | Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome | Hei Man Wu (+2) | 2021 | Translational Psychiatry |
| 5221 | Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank | Shu-Hong Lin (+9) | 2021 | Cell & Bioscience |
| 5971 | Utilizing Large Electronic Medical Record Data Sets to Identify Novel Drug-Gene Interactions for Commonly Used Drugs | Mustafa Adnan Malki (+4) | 2021 | Clinical Pharmacology & Therapeutics |
| 9775 | Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores | Ganna Leonenko (+7) | 2021 | Nature Communications |
| 5448 | Multivariate semi-blind deconvolution of fMRI time series | Hamza Cherkaoui (+4) | 2021 | NeuroImage |
| 5459 | New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis | Hélène Choquet (+7) | 2021 | Communications Biology |
| 6018 | X-chromosome influences on neuroanatomical variation in humans | Travis T. Mallard (+6) | 2021 | Nature Neuroscience |
| 4684 | Dietary fat intake and risk of disabling hearing impairment: a prospective population-based cohort study | Humberto Yévenes-Briones (+5) | 2021 | European Journal of Nutrition |
| 5400 | Migraine and gastrointestinal disorders in middle and old age: A UK Biobank study | Nike Zoe Welander (+5) | 2021 | Brain and Behavior |
| 5774 | Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants | Jonathan S. Stevenson (+3) | 2021 | Alzheimer's & Dementia |
| 7458 | Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition | Nadav Brandes (+2) | 2021 | Scientific Reports |
| 9774 | Exploring the genetic heterogeneity in major depression across diagnostic criteria | Bradley S. Jermy (+4) | 2021 | Molecular Psychiatry |
| 4510 | Citrus Consumption and Risk of Non-Melanoma Skin Cancer in the UK Biobank | Andrew R Marley (+5) | 2021 | Nutrition and Cancer |
| 4634 | Deep learning for sex classification in resting-state and task functional brain networks from the UK Biobank | Matthew Leming (+1) | 2021 | NeuroImage |
| 5668 | Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study | Jana J Anderson (+18) | 2021 | Journal of Thrombosis and Haemostasis |
| 7624 | Implementation and implications for polygenic risk scores in healthcare | John L. Slunecka (+8) | 2021 | Human Genomics |
| 7625 | Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry | Benjamin A. Satterfield (+21) | 2021 | Circulation Genomic and Precision Medicine |
| 5071 | Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders | Stefan van Duijvenboden (+7) | 2021 | Human Molecular Genetics |
| 5153 | Human Cytomegalovirus and Risk of Incident Cardiovascular Disease in United Kingdom Biobank | Elizabeth M Hamilton (+3) | 2021 | The Journal of Infectious Diseases |
| 5730 | Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes | Jakie Guertin (+14) | 2021 | Circulation Genomic and Precision Medicine |
| 7462 | eQTpLot: a user-friendly R package for the visualization of colocalization between eQTL and GWAS signals | Theodore G. Drivas (+2) | 2021 | BioData Mining |
| 9773 | Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools | Shahram Bahrami (+38) | 2021 | Brain |
| 3981 | Additive Effect of Periodontal Disease and Obesity on COVID-19 Outcomes | H. Larvin (+5) | 2021 | Journal of Dental Research |
| 4701 | Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals | Kira J. Stanzick (+23) | 2021 | Nature Communications |
| 4737 | DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life | Nicholas J. Thomas (+11) | 2021 | Diabetologia |
| 5138 | Higher adiposity and mental health: causal inference using Mendelian randomization | Francesco Casanova (+10) | 2021 | Human Molecular Genetics |
| 5479 | Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank | Heidi Foo (+6) | 2021 | Scientific Reports |
| 5536 | Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank | Xingxing Zhu (+6) | 2021 | Translational Psychiatry |
| 5785 | Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations | Danielle E. Haslam (+55) | 2021 | Circulation Genomic and Precision Medicine |
| 9772 | Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus | Pik Fang Kho (+7) | 2021 | Human Genetics |
| 5505 | Orbitofrontal cortex connectivity is associated with food reward and body weight in humans | Edmund T Rolls (+3) | 2021 | Social Cognitive and Affective Neuroscience |
| 12691 | The association of energy and macronutrient intake with all-cause mortality, cardiovascular disease and dementia: findings from 120 963 women and men in the UK Biobank | Briar L. McKenzie (+4) | 2021 | British Journal Of Nutrition |
| 4352 | Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants | Kuo CL et al. | 2021 | J Gerontol A Biol Sci Med Sci |
| 5037 | Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density | Daniel Schmitz (+5) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 8188 | InTACT: An adaptive and powerful framework for joint-tissue transcriptome-wide association studies | Ye Eun Bae (+2) | 2021 | Genetic Epidemiology |
| 9771 | The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank | Abeer F. Alharbi (+1) | 2021 | npj Genomic Medicine |
| 12692 | Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals | Aniruddh P. Patel (+4) | 2021 | Circulation |
| 4851 | Family history of diabetes and risk of SARS-COV-2 in UK Biobank: A prospective cohort study | Bhautesh Dinesh Jani (+15) | 2021 | Endocrinology Diabetes & Metabolism |
| 4691 | Difference in distribution functions: A new diffusion weighted imaging metric for estimating white matter integrity | Jing Du (+13) | 2021 | NeuroImage |
| 4437 | Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization | Lukkunaprasit T et al. | 2021 | Front Genet |
| 5915 | Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations | Wen J et al. | 2021 | Genes (Basel) |
| 4331 | Automated Quality-Controlled Cardiovascular Magnetic Resonance Pericardial Fat Quantification Using a Convolutional Neural Network in the UK Biobank | Andrew Bard (+10) | 2021 | Frontiers in Cardiovascular Medicine |
| 4516 | Clinical laboratory tests and five-year incidence of major depressive disorder: a prospective cohort study of 433,890 participants from the UK Biobank | Michael Wainberg (+5) | 2021 | Translational Psychiatry |
| 5085 | GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health | Yajie Zhao (+12) | 2021 | Nature Communications |
| 5213 | Improved genetic prediction of complex traits from individual-level data or summary statistics | Qianqian Zhang (+3) | 2021 | Nature Communications |
| 5324 | Lifetime depression and age-related changes in body composition, cardiovascular function, grip strength and lung function: sex-specific analyses in the UK Biobank | Mutz J et al. | 2021 | Aging (Albany NY) |
| 5969 | Using UK Biobank for sexual minority health research | Catherine L Saunders (+1) | 2021 | Journal of Comparative Effectiveness Research |
| 4069 | Analysis of rare coding variants in 200,000 exome-sequenced subjects reveals novel genetic risk factors for type 2 diabetes | David Curtis | 2021 | Diabetes/Metabolism Research and Reviews |
| 4405 | Can a data driven obesity classification system identify those at risk of severe COVID-19 in the UK Biobank cohort study? | Stephen Clark (+3) | 2021 | International Journal of Obesity |
| 5579 | Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control | Johanne Tremblay (+32) | 2021 | Diabetologia |
| 3896 | A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank | Guiying Dong (+4) | 2021 | Genome Medicine |
| 6009 | Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses | Alison R. Barton (+3) | 2021 | Nature Genetics |
| 9770 | Genetic Overlap Between Alzheimer's Disease and Depression Mapped Onto the Brain | Jennifer Monereo-Sánchez (+10) | 2021 | Frontiers in Neuroscience |
| 5229 | Increasing adiposity and the presence of cardiometabolic morbidity is associated with increased Covid-19-related mortality: results from the UK Biobank | Kiran H. K. Patel (+5) | 2021 | BMC Endocrine Disorders |
| 5544 | Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank | Eleanor L. Watts (+7) | 2021 | Cancer Causes & Control |
| 5696 | Sarcopenic obesity and the risk of hospitalization or death from coronavirus disease 2019: findings from UK Biobank | Thomas J. Wilkinson (+4) | 2021 | JCSM Rapid Communications |
| 5167 | Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program | Chloé Sarnowski (+27) | 2021 | PLOS ONE |
| 9769 | Development and validation of a clinical and genetic model for predicting risk of severe COVID-19 | Gillian S. Dite (+2) | 2021 | Epidemiology and Infection |
| 12693 | Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity | Parsa Akbari (+61) | 2021 | Science |
| 3274 | Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants | Gheorghe DA et al. | 2021 | J Child Psychol Psychiatry |
| 3854 | A Body Shape Index (ABSI), hip index, and risk of cancer in the UK Biobank cohort | Sofia Christakoudi (+3) | 2021 | Cancer Medicine |
| 3966 | Accelerometer-derived physical activity and risk of atrial fibrillation | Khurshid S et al. | 2021 | Eur Heart J |
| 4081 | Apolipoprotein E genotype, lifestyle and coronary artery disease: Gene-environment interaction analyses in the UK Biobank population | Bos MM et al. | 2021 | Atherosclerosis |
| 4112 | Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study | Wu PF et al. | 2021 | J Sport Health Sci |
| 4162 | Association between serum urate, gout and comorbidities: a case-control study using data from the UK Biobank | Sandoval-Plata G et al. | 2021 | Rheumatology (Oxford) |
| 4283 | Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients | Watling CZ et al. | 2021 | Clin Nutr |
| 4427 | Cardiovascular symptoms affect the patterns of habitual coffee consumption | Elina Hyppönen (+1) | 2021 | American Journal of Clinical Nutrition |
| 4563 | Common X-Chromosome Variants Are Associated with Parkinson Disease Risk | Le Guen Y et al. | 2021 | Ann Neurol |
| 4642 | Depression and interleukin-6 signaling: A Mendelian Randomization study | Kelly KM et al. | 2021 | Brain Behav Immun |
| 4726 | Does bariatric surgery reduce future hospital costs? A propensity score-matched analysis using UK Biobank Study data | Tingting Wu (+5) | 2021 | International Journal of Obesity |
| 4879 | Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study | Jacobs BM et al. | 2021 | Neurol Neuroimmunol Neuroinflamm |
| 4895 | Genetic architectures of proximal and distal colorectal cancer are partly distinct | Huyghe JR et al. | 2021 | Gut |
| 4943 | Genetic Susceptibility for Low Testosterone in Men and Its Implications in Biology and Screening: Data from the UK Biobank | Fantus RJ et al. | 2021 | Eur Urol Open Sci |
| 4971 | Genetically predicted circulating levels of copper and zinc are associated with osteoarthritis but not with rheumatoid arthritis | Zhou J et al. | 2021 | Osteoarthritis Cartilage |
| 5041 | Genome-Wide Association Study of Korean Asthmatics: A Comparison With UK Asthmatics | An J et al. | 2021 | Allergy Asthma Immunol Res |
| 5073 | Genomic partitioning of inbreeding depression in humans | Loic Yengo (+5) | 2021 | American Journal of Human Genetics |
| 5120 | Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study | Heianza Y et al. | 2021 | Clin Nutr |
| 5278 | Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease | Blauwendraat C et al. | 2021 | Ann Neurol |
| 5334 | Long term outcomes following critical care hospital admission: A prospective cohort study of UK biobank participants✰,★ | McPeake J et al. | 2021 | Lancet Reg Health Eur |
| 5378 | Mendelian randomization study on vitamin D levels and osteoarthritis risk: a concise report | Bergink AP et al. | 2021 | Rheumatology (Oxford) |
| 5409 | Modification of Heritability for Educational Attainment and Fluid Intelligence by Socioeconomic Deprivation in the UK Biobank | Rask-Andersen M et al. | 2021 | Am J Psychiatry |
| 5475 | NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants | Cho BPH et al. | 2021 | J Neurol Neurosurg Psychiatry |
| 5518 | Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization | Zhiqiang Sha (+2) | 2021 | Molecular Psychiatry |
| 5525 | Perinatal exposure to maternal smoking and adulthood smoking behaviors in predicting cardiovascular diseases: A prospective cohort study | Song Q et al. | 2021 | Atherosclerosis |
| 5569 | Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study | Kappelmann N et al. | 2021 | Brain Behav Immun |
| 5606 | Prevalence of Hypertrophic Cardiomyopathy in the UK Biobank Population | Luis R. Lopes (+5) | 2021 | JAMA Cardiology |
| 5767 | Socioeconomic deprivation and genetic ancestry interact to modify type 2 diabetes ethnic disparities in the United Kingdom | Nagar SD et al. | 2021 | EClinicalMedicine |
| 5842 | The effect of the anti-diabetic drug metformin on musculoskeletal pain: A cross-sectional study with 21,889 individuals from the UK biobank | Carvalho-E-Silva AP et al. | 2021 | Eur J Pain |
| 5928 | Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance | J. S. Talboom (+17) | 2021 | npj Aging |
| 7463 | Genetic Risk, Muscle Strength, and Incident Stroke: Findings From the UK Biobank Study | Youngwon Kim (+5) | 2021 | Mayo Clinic Proceedings |
| 12694 | Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour | Bastiaan T. Heijmans (+63) | 2021 | Nature Human Behaviour |
| 5010 | Genome-wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals | Chuan Gao (+16) | 2021 | Genetic Epidemiology |
| 5751 | Sleep and physical activity in relation to all-cause, cardiovascular disease and cancer mortality risk | Bo-Huei Huang (+5) | 2021 | British Journal of Sports Medicine |
| 12695 | Machine Learning Prediction of Biomarkers from SNPs and of Disease Risk from Biomarkers in the UK Biobank | Erik Widen (+3) | 2021 | Genes |
| 3995 | Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank | Joseph D. Szustakowski (+34) | 2021 | Nature Genetics |
| 5669 | Replacement of Sedentary Behavior by Various Daily-Life Physical Activities and Structured Exercises: Genetic Risk and Incident Type 2 Diabetes. | Xiang Li (+5) | 2021 | Diabetes Care |
| 7464 | Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study | Shuai Yuan (+4) | 2021 | Nutrients |
| 12696 | Ambient Air Pollutions Are Associated with Vitamin D Status | Chenlu Yang (+3) | 2021 | International Journal of Environmental Research and Public Health |
| 5645 | Rare Hypomorphic Sucrase Isomaltase Variants in Relation to Irritable Bowel Syndrome Risk in UK Biobank | Tenghao Zheng (+5) | 2021 | Gastroenterology |
| 5691 | Role of inflammation in depression and anxiety: Tests for disorder specificity, linearity and potential causality of association in the UK Biobank | Zheng Ye (+6) | 2021 | EClinicalMedicine |
| 7439 | Development of an accessible 10-year Digital CArdioVAscular (DiCAVA) risk assessment: a UK Biobank study | Nikola Dolezalova (+6) | 2021 | European Heart Journal - Digital Health |
| 9768 | Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort | Céline Dubath (+14) | 2021 | Translational Psychiatry |
| 4648 | Derivation and Validation of a 10-Year Risk Score for Symptomatic Abdominal Aortic Aneurysm | Paul Welsh (+14) | 2021 | Circulation |
| 5134 | High coffee consumption, brain volume and risk of dementia and stroke | Kitty Pham (+5) | 2021 | Nutritional Neuroscience |
| 3984 | Adherence to international dietary recommendations in association with all-cause mortality and fatal and non-fatal cardiovascular disease risk: a prospective analysis of UK Biobank participants | Maryam Kebbe (+4) | 2021 | BMC Medicine |
| 4225 | Association of pre-pandemic high-density lipoprotein cholesterol with risk of COVID-19 hospitalisation and death: The UK Biobank cohort study | Camille Lassale (+4) | 2021 | Preventive Medicine Reports |
| 9767 | Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis | Jennifer A. Sumner (+49) | 2021 | Frontiers in Neuroscience |
| 4030 | All coffee types decrease the risk of adverse clinical outcomes in chronic liver disease: a UK Biobank study | Oliver J. Kennedy (+5) | 2021 | BMC Public Health |
| 4702 | Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank's Pilot Imaging Enhancement Study | Katherine M. Livingstone (+9) | 2021 | Frontiers in Endocrinology |
| 4758 | Effects of increased body mass index on employment status: a Mendelian randomisation study | Desmond D. Campbell (+12) | 2021 | International Journal of Obesity |
| 5916 | Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing | Chiara Fabbri (+4) | 2021 | Neuropsychopharmacology |
| 4905 | Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment | Matthias Wielscher (+10) | 2021 | Genome Medicine |
| 5106 | GxEsum: a novel approach to estimate the phenotypic variance explained by genome-wide GxE interaction based on GWAS summary statistics for biobank-scale data | Jisu Shin (+1) | 2021 | Genome Biology |
| 5259 | Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study | Na Zhang (+8) | 2021 | Scientific Reports |
| 12697 | Body Mass Index and Birth Weight Improve Polygenic Risk Score for Type 2 Diabetes | Avigail Moldovan (+3) | 2021 | Journal of Personalized Medicine |
| 9757 | Fast numerical optimization for genome sequencing data in population biobanks | Ruilin Li (+6) | 2021 | Bioinformatics |
| 3848 | [Genetic study of cardiovascular disease subtypes defined by International Classification of Diseases] | Guo ZN et al. | 2021 | Beijing Da Xue Xue Bao Yi Xue Ban |
| 5355 | Mapping pleiotropic loci using a fast-sequential testing algorithm | Fernando M. Aguate (+3) | 2021 | European Journal of Human Genetics |
| 7460 | Common genetic variation influencing human white matter microstructure | Bingxin Zhao (+14) | 2021 | Science |
| 7461 | Poor sleep behavior burden and risk of COVID-19 mortality and hospitalization | Peng Li (+7) | 2021 | Sleep |
| 9756 | Genome-wide association study identifies five risk loci for pernicious anemia | Triin Laisk (+4) | 2021 | Nature Communications |
| 3587 | Resource profile and user guide of the Polygenic Index Repository | Joel Becker (+41) | 2021 | Nature Human Behaviour |
| 3958 | A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts | Yogasudha Veturi (+22) | 2021 | Nature Genetics |
| 4359 | Birth Weight and Adult Obesity Index in Relation to the Risk of Hypertension: A Prospective Cohort Study in the UK Biobank | Yi Zhang (+7) | 2021 | Frontiers in Cardiovascular Medicine |
| 4709 | Dissecting the midlife crisis: disentangling social, personality and demographic determinants in social brain anatomy | Hannah Kiesow (+4) | 2021 | Communications Biology |
| 5205 | Impact of replacing sedentary behaviour with other movement behaviours on depression and anxiety symptoms: a prospective cohort study in the UK Biobank | A. A. Kandola (+5) | 2021 | BMC Medicine |
| 5929 | Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes | Jana Sticht (+2) | 2021 | Frontiers in Genetics |
| 9749 | Mutational Landscape of the Proglucagon-Derived Peptides | Peter Lindquist (+4) | 2021 | Frontiers in Endocrinology |
| 4203 | Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts | Yuri Milaneschi (+8) | 2021 | Molecular Psychiatry |
| 4356 | Biomarker Concentrations in White and British Indian Vegetarians and Nonvegetarians in the UK Biobank | Tammy Y N Tong (+3) | 2021 | Journal of Nutrition |
| 5713 | Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank | Laura J. Horsfall (+2) | 2021 | Respiratory Research |
| 7626 | Rheumatoid arthritis and osteoporosis: shared genetic effect, pleiotropy and causality | Xing-Hao Yu (+6) | 2021 | Human Molecular Genetics |
| 3726 | Deep Learning to Predict Cardiac Magnetic Resonance-Derived Left Ventricular Mass and Hypertrophy From 12-Lead ECGs | Shaan Khurshid (+10) | 2021 | Circulation Cardiovascular Imaging |
| 4274 | Associations Between Sleep Quality and Health Span: A Prospective Cohort Study Based on 328,850 UK Biobank Participants | Muhammed Lamin Sambou (+9) | 2021 | Frontiers in Genetics |
| 4550 | Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals With Atrial Fibrillation | Jack W. O'Sullivan (+9) | 2021 | Circulation Genomic and Precision Medicine |
| 4662 | Developing automated methods for disease subtyping in UK Biobank: an exemplar study on stroke | Rannikmäe K et al. | 2021 | BMC Med Inform Decis Mak |
| 4891 | Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning | Yi Liu (+7) | 2021 | eLife |
| 5882 | Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank. | Victoria Garfield (+9) | 2021 | Diabetes |
| 7257 | Meaning in life and accelerometer-measured physical activity: Association based on 67,038 UK Biobank participants | Angelina R Sutin (+3) | 2021 | Mental Health and Physical Activity |
| 7258 | Association of Sickle Cell Trait with Risk and Mortality of COVID-19: Results from the United Kingdom Biobank | W. Kyle Resurreccion (+12) | 2021 | American Journal of Tropical Medicine and Hygiene |
| 3902 | A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects | Hélène Choquet (+10) | 2021 | Nature Communications |
| 5246 | Intake of processed meat, but not sodium, is associated with risk of colorectal cancer: Evidence from a large prospective cohort and two-sample Mendelian randomization | Qi Feng (+5) | 2021 | Clinical Nutrition |
| 5981 | Variance-component-based meta-analysis of gene-environment interactions for rare variants | Xiaoqin Jin (+1) | 2021 | G3: Genes, Genomes, Genetics |
| 12698 | SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe | Steven Hageman (+174) | 2021 | European Heart Journal |
| 3898 | A history of previous childbirths is linked to women's white matter brain age in midlife and older age | Irene Voldsbekk (+8) | 2021 | Human Brain Mapping |
| 9744 | Genome-wide survey of parent-of-origin-specific associations across clinical traits derived from electronic health records | Hye In Kim (+8) | 2021 | Human Genetics and Genomics Advances |
| 3886 | A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor | Harry D. Green (+8) | 2021 | PLOS Genetics |
| 4086 | Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants | Ziyi Zhou (+8) | 2021 | Diabetologia |
| 4378 | Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort | Peng Yun (+6) | 2021 | Cancer Medicine |
| 5639 | Rapid detection of identity-by-descent tracts for mega-scale datasets | Ruhollah Shemirani (+5) | 2021 | Nature Communications |
| 4661 | Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes | Julia K. Goodrich (+129) | 2021 | Nature Communications |
| 5655 | Reference values for intake of six types of soluble and insoluble fibre in healthy UK inhabitants based on the UK Biobank data | Artem Shevlyakov (+3) | 2021 | Public Health Nutrition |
| 9743 | The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis | Erna V. Ivarsdottir (+27) | 2021 | Communications Biology |
| 4102 | Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume | Andrew Thompson (+3) | 2021 | Human Molecular Genetics |
| 4273 | Associations between sleep disturbances, diabetes and mortality in the UK Biobank cohort: A prospective population-based study | Malcolm von Schantz (+2) | 2021 | Journal of Sleep Research |
| 5416 | Mortality in Patients With Genetic and Environmental Risk of Liver Disease | Carolin V. Schneider (+4) | 2021 | The American Journal of Gastroenterology |
| 5609 | Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank | Kim Valette (+22) | 2021 | Communications Biology |
| 5944 | Understanding Factors That Cause Tinnitus: A Mendelian Randomization Study in the UK Biobank | Manuela Cresswell (+6) | 2021 | Ear & Hearing |
| 8189 | Genotype-Phenotype Correlation in Trichilemmal Cysts | Ahmed Yousaf (+5) | 2021 | Journal of Investigative Dermatology |
| 9742 | Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health | Jessica O'Loughlin (+14) | 2021 | Molecular Psychiatry |
| 4952 | Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade | Zia Khan (+11) | 2021 | Nature Communications |
| 5029 | Genome-Wide Association Study Identifies Genetic Risk Factors for Spastic Cerebral Palsy | Andrew T Hale (+6) | 2021 | Neurosurgery |
| 5255 | Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head | Ma M et al. | 2021 | Front Genet |
| 5320 | Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs | Qingbo S. Wang (+12) | 2021 | Nature Communications |
| 5403 | Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences | Liron Ganel (+23) | 2021 | Human Genomics |
| 4264 | Associations between major psychiatric disorder polygenic risk scores and blood-based markers in UK biobank | Michael D E Sewell (+10) | 2021 | Brain Behavior and Immunity |
| 4428 | Cardiovascular-related deaths at the beginning of the COVID-19 outbreak: a prospective analysis based on the UK Biobank | Junren Wang (+9) | 2021 | BMJ Open |
| 5478 | Novel EDGE encoding method enhances ability to identify genetic interactions | Molly A. Hall (+20) | 2021 | PLOS Genetics |
| 5623 | Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder | Jessica Mundy (+191) | 2021 | Psychological Medicine |
| 12699 | Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far? | Michael A Chappell (+6) | 2021 | NeuroImage |
| 12700 | Association of body composition with risk of overall and site-specific cancers: A population-based prospective cohort study | Qiangsheng He (+16) | 2021 | International Journal of Cancer |
| 4676 | Diet and general cognitive ability in the UK Biobank dataset | Piril Hepsomali (+1) | 2021 | Scientific Reports |
| 5839 | The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study | Huaili Jiang (+5) | 2021 | Cancer & Metabolism |
| 4238 | Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry | Margaret M. Parker (+21) | 2021 | Scientific Reports |
| 5580 | Polygenic Risk Scores Stratify Keratinocyte Cancer Risk among Solid Organ Transplant Recipients with Chronic Immunosuppression in a High Ultraviolet Radiation Environment | Mathias Seviiri (+14) | 2021 | Journal of Investigative Dermatology |
| 7627 | Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family | Amaia Carrion-Castillo (+5) | 2021 | Human Genetics |
| 3243 | Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries | Weale ME et al. | 2021 | Am J Cardiol |
| 4024 | Alcohol Consumption and Incident Cataract Surgery in Two Large UK Cohorts | Chua SYL et al. | 2021 | Ophthalmology |
| 4025 | Alcohol consumption in the general population is associated with structural changes in multiple organ systems | Evangelou E et al. | 2021 | Elife |
| 4231 | Association of sarcopenia with mortality and end-stage renal disease in those with chronic kidney disease: a UK Biobank study | Wilkinson TJ et al. | 2021 | J Cachexia Sarcopenia Muscle |
| 4323 | Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA | Xikun Han (+12) | 2021 | American Journal of Human Genetics |
| 4369 | Blood Pressure Determinants of Cerebral White Matter Hyperintensities and Microstructural Injury: UK Biobank Cohort Study | Karolina A. Wartolowska (+1) | 2021 | Hypertension |
| 4446 | Causal Effects of Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism on Kidney Function: A Mendelian Randomization Study | Sehoon Park (+13) | 2021 | Journal of the American Society of Nephrology |
| 4671 | Diabetes duration and glycaemic control as predictors of cardiovascular disease and mortality | Li FR et al. | 2021 | Diabetes Obes Metab |
| 4753 | Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives | Richardson TG et al. | 2021 | Lancet Healthy Longev |
| 4810 | Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia | Tideman JWL et al. | 2021 | JAMA Ophthalmol |
| 5110 | Habitual coffee intake and risk for nonalcoholic fatty liver disease: a two-sample Mendelian randomization study | Zhang Y et al. | 2021 | Eur J Nutr |
| 5220 | Inborn and acquired risk factors for severe liver disease in Europeans with type 2 diabetes from the UK Biobank | Tavaglione F et al. | 2021 | JHEP Rep |
| 5267 | Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank | Kim J et al. | 2021 | Ophthalmology |
| 5291 | Joint Associations of Actual Age and Genetically Determined Age at Menarche With Risk of Mortality | Liang Z et al. | 2021 | JAMA Netw Open |
| 5307 | Large-scale machine-learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology | Babak Alipanahi (+14) | 2021 | American Journal of Human Genetics |
| 5375 | Mendelian Randomization Analysis Reveals Causal Effects of the Human Gut Microbiota on Abdominal Obesity | Qian Xu (+9) | 2021 | Journal of Nutrition |
| 5760 | Smoking and heart failure: a Mendelian randomization and mediation analysis | Lu Y et al. | 2021 | ESC Heart Fail |
| 5903 | Three genes associated with anterior and posterior cruciate ligament injury : a genome-wide association analysis | Kim SK et al. | 2021 | Bone Jt Open |
| 7286 | Haploinsufficiency of the HIRA gene may not always produce severe neurodevelopmental consequences | David Curtis | 2021 | Psychiatric Genetics |
| 9688 | Associations between Prediagnostic Circulating Bilirubin Levels and Risk of Gastrointestinal Cancers in the UK Biobank | Nazlisadat Seyed Khoei (+5) | 2021 | Cancers |
| 12701 | Genetic Susceptibility to Pneumonia: A GWAS Meta-Analysis Between the UK Biobank and FinnGen | Adrian I. Campos (+6) | 2021 | Twin Research and Human Genetics |
| 4156 | Association between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank | Andrea Weber (+6) | 2021 | British Journal of Cancer |
| 4267 | Associations between multimorbidity and depression among breast cancer survivors within the UK Biobank cohort: a cross-sectional study | Murray Foster (+1) | 2021 | BMC Cancer |
| 4927 | Genetic pleiotropy of ERCC6 loss-of-function and deleterious missense variants links retinal dystrophy, arrhythmia, and immunodeficiency in diverse ancestries | Iain S. Forrest (+11) | 2021 | Human Mutation |
| 4972 | Genetically predicted circulating vitamin C in relation to cardiovascular disease | Shuai Yuan (+4) | 2021 | European Journal of Preventive Cardiology |
| 5292 | Joint associations of adiposity and alcohol consumption with liver disease-related morbidity and mortality risk: findings from the UK Biobank | Elif Inan-Eroglu (+5) | 2021 | European Journal of Clinical Nutrition |
| 5783 | Subclinical Changes in Cardiac Functional Parameters as Determined by Cardiovascular Magnetic Resonance (CMR) Imaging in Sleep Apnea and Snoring: Findings from UK Biobank | Adrian Curta (+14) | 2021 | Medicina |
| 4945 | Genetic underpinnings of sociability in the general population | Janita Bralten (+16) | 2021 | Neuropsychopharmacology |
| 4181 | Association of COA1 with Patellar Tendonitis: A Genome-wide Association Analysis | STUART K. KIM (+4) | 2021 | Medicine & Science in Sports & Exercise |
| 12870 | Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma | Marco Fangazio (+19) | 2021 | Proceedings of the National Academy of Sciences of the United States of America |
| 4263 | Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants | Rebecca K. Kelly (+7) | 2021 | Arteriosclerosis Thrombosis and Vascular Biology |
| 4343 | Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions | Daniel F. Levey (+17) | 2021 | Nature Neuroscience |
| 4798 | Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene-environment interaction analysis in UK Biobank cohort | Yao Yao (+17) | 2021 | Endocrine |
| 5527 | Periodontitis and pulmonary function: a Mendelian randomization study | Sebastian-Edgar Baumeister (+6) | 2021 | Clinical Oral Investigations |
| 4898 | Genetic associations for two biological age measures point to distinct aging phenotypes | Chia-Ling Kuo (+4) | 2021 | Aging Cell |
| 5151 | How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis | Ana G Soares (+7) | 2021 | International Journal of Epidemiology |
| 5905 | Thyroid dysfunction and breast cancer risk among women in the UK Biobank cohort | Thi-Van-Trinh Tran (+5) | 2021 | Cancer Medicine |
| 9686 | The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic AnalysisCost-effectiveness of Risk-Stratification For colorectal cancer Screening | Chloe Thomas (+6) | 2021 | Cancer Prevention Research |
| 4129 | Association between birth weight and risk of cardiovascular disease: Evidence from UK Biobank | Jingjia Liang (+8) | 2021 | Nutrition Metabolism and Cardiovascular Diseases |
| 4704 | Disease trajectories and mortality among individuals diagnosed with depression: a community-based cohort study in UK Biobank | Xin Han (+13) | 2021 | Molecular Psychiatry |
| 5793 | Systemic inflammation markers and cancer incidence in the UK Biobank | Therese Haugdahl Nøst (+6) | 2021 | European Journal of Epidemiology |
| 5978 | Validation of the Dallas Steatosis Index to Predict Nonalcoholic Fatty Liver Disease in the UK Biobank Population | Scott McHenry (+2) | 2021 | Clinical Gastroenterology and Hepatology |
| 9685 | Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit | Timothy V. Pyrkov (+5) | 2021 | Nature Communications |
| 4643 | Depression and Vegetarians: Association between Dietary Vitamin B6, B12 and Folate Intake and Global and Subcortical Brain Volumes | Samuel Berkins (+2) | 2021 | Nutrients |
| 4812 | Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals | Karani Santhanakrishnan Vimaleswaran (+3) | 2021 | International Journal of Obesity |
| 5982 | Variants associated with HHIP expression have sex-differential effects on lung function | Katherine A. Fawcett (+74) | 2021 | Wellcome Open Research |
| 12871 | Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India | Amit Kumar (+23) | 2021 | Neurology |
| 4320 | Atrial fibrillation and kidney function: a bidirectional Mendelian randomization study | Sehoon Park (+13) | 2021 | European Heart Journal |
| 5302 | Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche | C Sarnowski (+24) | 2021 | Human Reproduction |
| 4922 | Genetic insight into sick sinus syndrome | Thorolfsdottir RB et al. | 2021 | Eur Heart J |
| 5101 | GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer | Sofia Christakoudi (+3) | 2021 | Scientific Reports |
| 5316 | Leveraging eQTLs to identify individual-level tissue of interest for a complex trait | Arunabha Majumdar (+7) | 2021 | PLOS Computational Biology |
| 9684 | Polygenic Scores and Parental Predictors: An Adult Height Study Based on the United Kingdom Biobank and the Framingham Heart Study | Chong You (+10) | 2021 | Frontiers in Genetics |
| 4136 | Association Between Environmental Factors and Asthma Using Mendelian Randomization: Increased Effect of Body Mass Index on Adult-Onset Moderate-to-Severe Asthma Subtypes | Tae-Woong Ha (+8) | 2021 | Frontiers in Genetics |
| 4592 | Computationally efficient whole-genome regression for quantitative and binary traits | Joelle Mbatchou (+16) | 2021 | Nature Genetics |
| 5251 | Integrating large-scale neuroimaging research datasets: Harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets | Valentina Bordin (+19) | 2021 | NeuroImage |
| 5617 | Prospective study of sleep duration and glioma risk | Claudine M. Samanic (+6) | 2021 | Cancer Causes & Control |
| 4777 | Endometrial Cancer, BRCA1, and BRCA2 in the UK Biobank Cohort | Steven Lehrer (+1) | 2021 | American Journal of Clinical Oncology |
| 5720 | Sex differences in the association between major cardiovascular risk factors in midlife and dementia: a cohort study using data from the UK Biobank | Jessica Gong (+3) | 2021 | BMC Medicine |
| 5790 | Symptom dimensions of major depression in a large community-based cohort | Michael Wainberg (+7) | 2021 | Psychological Medicine |
| 5585 | Population-based body-brain mapping links brain morphology with anthropometrics and body composition | Tiril P. Gurholt (+16) | 2021 | Translational Psychiatry |
| 5707 | Sensory, somatomotor and internal mentation networks emerge dynamically in the resting brain with internal mentation predominating in older age | Lu Zhang (+11) | 2021 | NeuroImage |
| 5845 | The effects of education on cognition in older age: Evidence from genotyped Siblings | Jason Fletcher (+3) | 2021 | Social Science & Medicine |
| 9683 | The genetic architecture of the human thalamus and its overlap with ten common brain disorders | Torbjørn Elvsåshagen (+9) | 2021 | Nature Communications |
| 4043 | An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank | Ekaterina Yonova-Doing (+7) | 2021 | Nature Genetics |
| 7287 | Estimating colocalization probability from limited summary statistics | Emily A. King (+3) | 2021 | BMC Bioinformatics |
| 4285 | Associations of cognitive performance with cardiovascular magnetic resonance phenotypes in the UK Biobank | Raisi-Estabragh Z et al. | 2021 | Eur Heart J Cardiovasc Imaging |
| 4774 | Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank | Maria C Pitharouli (+6) | 2021 | American Journal of Psychiatry |
| 5379 | Mendelian randomization: estimation of inpatient hospital costs attributable to obesity | Katherine Dick (+5) | 2021 | Health Economics Review |
| 7465 | Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions | Anthony S Findley (+13) | 2021 | eLife |
| 9682 | Lack of Support for the Genes by Early Environment Interaction Hypothesis in the Pathogenesis of Schizophrenia | Evangelos Vassos (+17) | 2021 | Schizophrenia Bulletin |
| 5591 | Predicting sex from retinal fundus photographs using automated deep learning | Edward Korot (+9) | 2021 | Scientific Reports |
| 5979 | Variability in Brain Structure and Function Reflects Lack of Peer Support | Matthias Schurz (+7) | 2021 | Cerebral Cortex |
| 7288 | SARS-CoV-2 infection in alpha1-antitrypsin deficiency | Carolin V Schneider (+1) | 2021 | Respiratory Medicine |
| 12872 | Potential recruitment into a clinical trial of vascular secondary prevention medications in cerebral small vessel disease, based on concomitant medication use | Edward Morrison (+7) | 2021 | Cerebral Circulation - Cognition and Behavior |
| 4915 | Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease. | Susan Martin (+12) | 2021 | Diabetes |
| 4950 | Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images | Hannah Currant (+35) | 2021 | PLOS Genetics |
| 5163 | Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank | Elizabeth L. Yanik (+7) | 2021 | Journal of Bone and Joint Surgery |
| 9681 | Assessment of significance of conditionally independent GWAS signals | Sahar Ghasemi (+3) | 2021 | Bioinformatics |
| 4308 | Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian Longitudinal Study on Aging | Xikun Han (+6) | 2021 | BMC Medicine |
| 4681 | Diet, Physical Activity, and Disinhibition in Middle-Aged and Older Adults: A UK Biobank Study | Lizanne J. S. Schweren (+9) | 2021 | Nutrients |
| 5736 | Sexual and physical abuse and depressive symptoms in the UK Biobank | Anna B. Chaplin (+2) | 2021 | BMC Psychiatry |
| 7466 | Are a lack of social relationships and cigarette smoking really equally powerful predictors of mortality? Analyses of data from two cohort studies | G. David Batty (+3) | 2021 | Public Health in Practice |
| 4026 | Alcohol Consumption Is Associated with Poor Prognosis in Obese Patients with COVID-19: A Mendelian Randomization Study Using UK Biobank | Fan X et al. | 2021 | Nutrients |
| 4885 | Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes | Raha Pazoki (+34) | 2021 | Nature Communications |
| 5717 | Sex differences in experiences of multiple traumas and mental health problems in the UK Biobank cohort | Emma Yapp (+8) | 2021 | Social Psychiatry and Psychiatric Epidemiology |
| 5778 | Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles | Raymond Noordam (+13) | 2021 | Diabetes |
| 7467 | Optimising a Simple Fully Convolutional Network for Accurate Brain Age Prediction in the PAC 2019 Challenge | Weikang Gong (+4) | 2021 | Frontiers in Psychiatry |
| 7468 | The consequences of adjustment, correction and selection in genome-wide association studies used for two-sample Mendelian randomization | Venexia Walker (+5) | 2021 | Wellcome Open Research |
| 9680 | Single-participant structural similarity matrices lead to greater accuracy in classification of participants than function in autism in MRI | Matthew J. Leming (+2) | 2021 | Molecular Autism |
| 5033 | Genome-wide association study of cardiac troponin I in the general population | Marta R Moksnes (+29) | 2021 | Human Molecular Genetics |
| 5314 | Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction | Clara Albiñana (+12) | 2021 | American Journal of Human Genetics |
| 4650 | Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank | Aurora Perez-Cornago (+8) | 2021 | European Journal of Nutrition |
| 4926 | Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight | Jeffrey J Beck (+33) | 2021 | Human Molecular Genetics |
| 5279 | Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants | Muhammed Lamin Sambou (+7) | 2021 | Sleep and Breathing |
| 5298 | Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study | Sehoon Park (+12) | 2021 | European Respiratory Journal |
| 7289 | Effects of Screenings in Reducing Colorectal Cancer Incidence and Mortality Differ by Polygenic Risk Scores | Jungyoon Choi (+5) | 2021 | Clinical and Translational Gastroenterology |
| 3824 | Neurological diseases and COVID-19: prospective analyses using the UK Biobank | Nicola Veronese (+9) | 2021 | Acta Neurologica Belgica |
| 4300 | Associations of Meat and Fish Consumption With Conventional and Radiomics Cardiovascular Magnetic Resonance Phenotypes in the UK Biobank | Zahra Raisi-Estabragh (+13) | 2021 | Frontiers in Cardiovascular Medicine |
| 5810 | The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study | Christensen RAG et al. | 2021 | PLoS One |
| 9679 | Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease | Scott E. Youlten (+36) | 2021 | Nature Communications |
| 3916 | A new method for exploring gene-gene and gene-environment interactions in GWAS with tree ensemble methods and SHAP values | Pål V. Johnsen (+4) | 2021 | BMC Bioinformatics |
| 4809 | Evaluation of polygenic prediction methodology within a reference-standardized framework | Oliver Pain (+11) | 2021 | PLOS Genetics |
| 5390 | Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population | Heli Julkunen (+3) | 2021 | eLife |
| 4045 | An Empirically Derived Definition of Metabolically Healthy Obesity Based on Risk of Cardiovascular and Total Mortality | Zembic A et al. | 2021 | JAMA Netw Open |
| 5877 | The morphometry of left cuneus mediating the genetic regulation on working memory | Xiaoxi He (+9) | 2021 | Human Brain Mapping |
| 4327 | Automated Detection of Glaucoma With Interpretable Machine Learning Using Clinical Data and Multimodal Retinal Images | Parmita Mehta (+11) | 2021 | American Journal of Ophthalmology |
| 5715 | Sex and APOE genotype differences related to statin use in the aging population | Dagliati A et al. | 2021 | Alzheimers Dement (N Y) |
| 3365 | Coffee consumption and risk of hearing impairment in men and women | Machado-Fragua MD et al. | 2021 | Clin Nutr |
| 4117 | Assessment of the causal relevance of ECG parameters for risk of atrial fibrillation: A mendelian randomisation study | Gajendragadkar PR et al. | 2021 | PLoS Med |
| 4309 | Associations of sleep duration and quality with incident cardiovascular disease, cancer, and mortality: a prospective cohort study of 407,500 UK biobank participants | Tao F et al. | 2021 | Sleep Med |
| 4322 | Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study | Tamman AJF et al. | 2021 | Biol Psychiatry |
| 4394 | HbA1c and brain health across the entire glycaemic spectrum | Garfield V et al. | 2021 | Diabetes Obes Metab |
| 4547 | Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk | Burcu F Darst (+5) | 2021 | European Urology |
| 4572 | Comparison and impact of COVID-19 for patients with cancer: a survival analysis of fatality rate controlling for age, sex and cancer type | Li H et al. | 2021 | BMJ Health Care Inform |
| 4639 | Deep-learning-based cardiovascular risk stratification using coronary artery calcium scores predicted from retinal photographs | Rim TH et al. | 2021 | Lancet Digit Health |
| 4783 | Estimated salt intake and risk of atrial fibrillation in a prospective community-based cohort | Wuopio J et al. | 2021 | J Intern Med |
| 4790 | Estimating the causal effect of BMI on mortality risk in people with heart disease, diabetes and cancer using Mendelian randomization | Jenkins DA et al. | 2021 | Int J Cardiol |
| 4878 | Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach | Warrier V et al. | 2021 | Lancet Psychiatry |
| 4976 | Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants: A mendelian randomization study | Larsson SC et al. | 2021 | Clin Nutr |
| 5023 | Genome-wide Association Study and Meta-analysis on Alcohol-Associated Liver Cirrhosis Identifies Genetic Risk Factors | Tae-Hwi Schwantes-An (+33) | 2021 | Hepatology |
| 5113 | Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank | Hao Ma (+3) | 2021 | American Journal of Clinical Nutrition |
| 5194 | Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study | Freuer D et al. | 2021 | Metabolism |
| 5432 | Multi-omic analysis elucidates the genetic basis of hydrocephalus | Andrew T Hale (+5) | 2021 | Cell Reports |
| 5495 | Observational or Genetically Predicted Higher Vegetable Intake and Kidney Function Impairment: An Integrated Population-Scale Cross-Sectional Analysis and Mendelian Randomization Study | Sehoon Park (+13) | 2021 | Journal of Nutrition |
| 5588 | Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer | Song H et al. | 2021 | J Med Genet |
| 5729 | Sex-specific associations of circulating testosterone levels with all-cause and cause-specific mortality | Jiayu Wang (+10) | 2021 | European Journal of Endocrinology |
| 5758 | Smoking and COVID-19 Infection and Related Mortality: A Prospective Cohort Analysis of UK Biobank Data | Albert Prats-Uribe (+3) | 2021 | Clinical Epidemiology |
| 7469 | Brain Structural Differences in the Salience-Sensorimotor Networks of People Reporting Chronic Pain in the UK Biobank | Ravi R. Bhatt (+4) | 2021 | Biological Psychiatry |
| 7470 | Does the Common Type 2 Diabetes-Susceptibility Variant in the MTNR1B Gene Matter for Glycemic Control Among Patients on Antidiabetic Pharmacotherapy? | Xiao Tan (+1) | 2021 | Mayo Clinic Proceedings |
| 7629 | A Novel Two-Stage Heart Arrhythmia Ensemble Classifier | Mercedeh J. Rezaei (+3) | 2021 | Computers |
| 9677 | Lifestyle risk factors and infectious disease mortality, including COVID-19, among middle aged and older adults: Evidence from a community-based cohort study in the United Kingdom | Matthew N Ahmadi (+4) | 2021 | Brain Behavior and Immunity |
| 4350 | Biobank Scale Pharmacogenomics Informs the Genetic Underpinnings of Simvastatin Use | Frank R. Wendt (+5) | 2021 | Clinical Pharmacology & Therapeutics |
| 4002 | Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank | Mengyu Li (+3) | 2021 | Scientific Reports |
| 4265 | Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring: Findings From the Northern Finland Birth Cohort 1986 | Ramsay H et al. | 2021 | Schizophr Bull |
| 5030 | Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain | Shafiqur Rahman (+31) | 2021 | Annals of the Rheumatic Diseases |
| 5589 | Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies | Yiyang Yue (+10) | 2021 | Scientific Reports |
| 9676 | Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation | Louisa Goumidi (+27) | 2021 | Blood |
| 4059 | Analysis of 200 000 exome-sequenced UK Biobank subjects illustrates the contribution of rare genetic variants to hyperlipidaemia | David Curtis | 2021 | Journal of Medical Genetics |
| 4448 | Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study | Sehoon Park (+13) | 2021 | Nutrients |
| 4844 | Eyeglasses Reduce Risk of COVID-19 Infection | Steven Lehrer (+1) | 2021 | In Vivo |
| 7471 | An intronic variant in the CELF4 gene is associated with risk for colorectal cancer | Craig C Teerlink (+4) | 2021 | Cancer Epidemiology |
| 9675 | ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease | Pyry Helkkula (+9) | 2021 | PLOS Genetics |
| 5765 | Social deprivation as a risk factor for COVID-19 mortality among women and men in the UK Biobank: nature of risk and context suggests that social interventions are essential to mitigate the effects of future pandemics | Mark Woodward (+2) | 2021 | Journal of Epidemiology & Community Health |
| 4983 | Genetically Determined Higher TSH Is Associated With a Lower Risk of Diabetes Mellitus in Individuals With Low BMI | Maxime M Bos (+4) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 5744 | Shift work is associated with positive COVID-19 status in hospitalised patients | Robert Maidstone (+5) | 2021 | Thorax |
| 5961 | Using Genetic Marginal Effects to Study Gene-Environment Interactions with GWAS Data | Brad Verhulst (+3) | 2021 | Behavior Genetics |
| 12873 | Educational attainment does not influence brain aging | Lars Nyberg (+23) | 2021 | Proceedings of the National Academy of Sciences of the United States of America |
| 5276 | Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants | Curtis D | 2021 | Alcohol Alcohol |
| 5601 | Pre-pandemic cognitive function and COVID-19 mortality: prospective cohort study | George David Batty (+2) | 2021 | European Journal of Epidemiology |
| 7472 | Biophysics-based statistical learning: Application to heart and brain interactions | Jaume Banus (+3) | 2021 | Medical Image Analysis |
| 9673 | Triangulating Molecular Evidence to Prioritize Candidate Causal Genes at Established Atopic Dermatitis Loci | Maria K. Sobczyk (+6) | 2021 | Journal of Investigative Dermatology |
| 9672 | The impact of non-additive genetic associations on age-related complex diseases | Marta Guindo-Martínez (+20) | 2021 | Nature Communications |
| 4245 | Association of working shifts, inside and outside of healthcare, with severe COVID−19: an observational study | A. V. Rowlands (+11) | 2021 | BMC Public Health |
| 4256 | Associations between dietary patterns and the incidence of total and fatal cardiovascular disease and all-cause mortality in 116,806 individuals from the UK Biobank: a prospective cohort study | Min Gao (+7) | 2021 | BMC Medicine |
| 4617 | Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank | Antonella De Lillo (+6) | 2021 | Human Molecular Genetics |
| 4883 | Genetic analyses identify widespread sex-differential participation bias | Nicola Pirastu (+28) | 2021 | Nature Genetics |
| 4984 | Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization | William J. Young (+11) | 2021 | Circulation Genomic and Precision Medicine |
| 5962 | Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study | Mark Gormley (+21) | 2021 | PLOS Genetics |
| 5996 | Voxel-wise and spatial modelling of binary lesion masks: Comparison of methods with a realistic simulation framework | Petya Kindalova (+2) | 2021 | NeuroImage |
| 12874 | QDECR: A Flexible, Extensible Vertex-Wise Analysis Framework in R | Sander Lamballais (+1) | 2021 | Frontiers in Neuroinformatics |
| 3962 | ABO blood groups, COVID-19 infection and mortality | Steven Lehrer (+1) | 2021 | Blood Cells Molecules and Diseases |
| 4640 | Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients | Ana C. Tahira (+2) | 2021 | Alzheimer's & Dementia |
| 4438 | Causal effect of alcohol use on the risk of end-stage kidney disease and related comorbidities: a Mendelian randomization study | Sehoon Park (+13) | 2021 | Kidney Research and Clinical Practice |
| 4498 | Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization AnalysesSex Steroid Hormones and Colorectal Cancer Risk | Niki Dimou (+21) | 2021 | Cancer Epidemiology Biomarkers & Prevention |
| 4508 | Cis-epistasis at the LPA locus and risk of cardiovascular diseases | Zeng L et al. | 2021 | Cardiovasc Res |
| 5072 | Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis | Sven E. Ojavee (+9) | 2021 | Nature Communications |
| 5215 | Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging | Kaida Ning (+7) | 2021 | Neurobiology of Aging |
| 5949 | Understanding the Variability in Graph Data Sets through Statistical Modeling on the Stiefel Manifold | Clément Mantoux (+5) | 2021 | Entropy |
| 4048 | An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank | Stephen M. Smith (+6) | 2021 | Nature Neuroscience |
| 4307 | Associations of Skeletal Muscle Mass and Fat Mass With Incident Cardiovascular Disease and All-Cause Mortality: A Prospective Cohort Study of UK Biobank Participants | Rebecca Knowles (+5) | 2021 | Journal of the American Heart Association |
| 4321 | Atrial fibrillation and left atrial size and function: a Mendelian randomization study | Yordi J. van de Vegte (+3) | 2021 | Scientific Reports |
| 4776 | Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank | Sandar Tin Tin (+2) | 2021 | British Journal of Cancer |
| 5057 | Genome-wide gene-diet interaction analysis in the UK Biobank identifies novel effects on hemoglobin A1c | Kenneth E Westerman (+6) | 2021 | Human Molecular Genetics |
| 4018 | Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines | Madole JW et al. | 2021 | Biol Psychiatry |
| 5093 | Gout, Rheumatoid Arthritis, and the Risk of Death Related to Coronavirus Disease 2019: An Analysis of the UK Biobank | Ruth K. Topless (+6) | 2021 | ACR Open Rheumatology |
| 5133 | High Blood Pressure and Risk of Dementia: A Two-Sample Mendelian Randomization Study in the UK Biobank | Sproviero W et al. | 2021 | Biol Psychiatry |
| 5791 | Symptom-level modelling unravels the shared genetic architecture of anxiety and depression | Jackson G. Thorp (+13) | 2021 | Nature Human Behaviour |
| 9669 | Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction | Nicholette D Palmer (+35) | 2021 | Human Molecular Genetics |
| 4298 | Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: two prospective cohort studies | Zhang YB et al. | 2021 | BMJ |
| 4183 | Association of common TMPRSS6 and TF gene variants with hepcidin and iron status in healthy rural Gambians | Jallow MW et al. | 2021 | Sci Rep |
| 9668 | Identifying therapeutic drug targets using bidirectional effect genes | Karol Estrada (+14) | 2021 | Nature Communications |
| 4569 | Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom | Hilary A. Robbins (+10) | 2021 | British Journal of Cancer |
| 4840 | Extension of Mendelian Randomization to Identify Earliest Manifestations of Alzheimer Disease: Association of Genetic Risk Score for Alzheimer Disease With Lower Body Mass Index by Age 50 Years | Willa D Brenowitz (+8) | 2021 | American Journal of Epidemiology |
| 5662 | Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study | Yoshihiko Raita (+6) | 2021 | Frontiers in Medicine |
| 4021 | Alcohol affordability: implications for alcohol price policies. A cross-sectional analysis in middle and older adults from UK Biobank | Moore SC et al. | 2021 | J Public Health (Oxf) |
| 4312 | Associations of vitamin D status with colorectal cancer risk and survival | Jian Zhou (+5) | 2021 | International Journal of Cancer |
| 4411 | Cannabis, schizophrenia genetic risk, and psychotic experiences: a cross-sectional study of 109,308 participants from the UK Biobank | Michael Wainberg (+3) | 2021 | Translational Psychiatry |
| 4970 | Genetically predicted circulating B vitamins in relation to digestive system cancers | Shuai Yuan (+6) | 2021 | British Journal of Cancer |
| 4979 | Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study | Shuai Yuan (+6) | 2021 | Journal of the American Heart Association |
| 5308 | Large-Scale Phenomic and Genomic Analysis of Brain Asymmetrical Skew | Xiang-Zhen Kong (+9) | 2021 | Cerebral Cortex |
| 3913 | A model and test for coordinated polygenic epistasis in complex traits | Brooke Sheppard (+5) | 2021 | Proceedings of the National Academy of Sciences of the United States of America |
| 4558 | Common genetic associations between age-related diseases | Handan Melike Dönertaş (+4) | 2021 | Nature Aging |
| 4767 | Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes | Wenjian Bi (+5) | 2021 | American Journal of Human Genetics |
| 5735 | Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank | Keira J. A. Johnston (+10) | 2021 | PLOS Genetics |
| 4445 | Causal effects of physical activity or sedentary behaviors on kidney function: an integrated population-scale observational analysis and Mendelian randomization study | Sehoon Park (+13) | 2021 | Nephrology Dialysis Transplantation |
| 4797 | Ethnic minorities and COVID-19: examining whether excess risk is mediated through deprivation | Cameron Razieh (+9) | 2021 | European Journal of Public Health |
| 5621 | Psoriatic arthritis is associated with adverse body composition predictive of greater coronary heart disease and type 2 diabetes propensity - a cross-sectional study | Ferguson LD et al. | 2021 | Rheumatology (Oxford) |
| 5986 | Variation in VKORC1 Is Associated with Vascular Dementia | Mur J et al. | 2021 | J Alzheimers Dis |
| 6015 | Women With Diabetes Are at Increased Relative Risk of Heart Failure Compared to Men: Insights From UK Biobank | Sucharitha Chadalavada (+6) | 2021 | Frontiers in Cardiovascular Medicine |
| 7473 | Super-Resolution of Cardiac MR Cine Imaging using Conditional GANs and Unsupervised Transfer Learning | Yan Xia (+5) | 2021 | Medical Image Analysis |
| 9626 | Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data | Arman Eshaghi (+11) | 2021 | Nature Communications |
| 5665 | Relationships between sleep traits and lung cancer risk: a prospective cohort study in UK Biobank | Junxing Xie (+15) | 2021 | Sleep |
| 4793 | Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals | Valentin Hivert (+7) | 2021 | American Journal of Human Genetics |
| 5630 | Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data | Ali Pazokitoroudi (+4) | 2021 | American Journal of Human Genetics |
| 3242 | Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction | Riveros-Mckay F et al. | 2021 | Circ Genom Precis Med |
| 3884 | A Genome-wide Association Study for Concussion Risk | Kim SK et al. | 2021 | Med Sci Sports Exerc |
| 3957 | A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits | Cai M et al. | 2021 | Am J Hum Genet |
| 4022 | Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence | Sanchez-Roige S et al. | 2021 | Drug Alcohol Depend |
| 4110 | Assessing the Role of Rare Genetic Variation in Patients With Heart Failure | Povysil G et al. | 2021 | JAMA Cardiol |
| 4239 | Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study | Davies NG et al. | 2021 | Lancet Infect Dis |
| 4337 | Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank | Ryan J. Scalsky (+5) | 2021 | PLOS ONE |
| 4443 | Causal effects of homocysteine levels on the changes of bone mineral density and risk for bone fracture: A two-sample mendelian randomization study | Wang P et al. | 2021 | Clin Nutr |
| 4447 | Causal effects of relative fat, protein, and carbohydrate intake on chronic kidney disease: a Mendelian randomization study | Sehoon Park (+13) | 2021 | American Journal of Clinical Nutrition |
| 4585 | Comparisons of Polyexposure, Polygenic, and Clinical Risk Scores in Risk Prediction of Type 2 Diabetes | He Y et al. | 2021 | Diabetes Care |
| 4680 | Diet quality indices, genetic risk and risk of cardiovascular disease and mortality: a longitudinal analysis of 77 004 UK Biobank participants | Katherine M Livingstone (+5) | 2021 | BMJ Open |
| 4953 | Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study | Bowden SJ et al. | 2021 | Lancet Oncol |
| 5346 | Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease | Jensen MP et al. | 2021 | Ann Neurol |
| 5473 | Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores | Bianco C et al. | 2021 | J Hepatol |
| 5766 | Social isolation and risk of heart disease and stroke: analysis of two large UK prospective studies | Smith RW et al. | 2021 | Lancet Public Health |
| 7474 | Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R | Michael N Weedon (+3) | 2021 | Cell |
| 9622 | A Mendelian Randomization Study of Plasma Homocysteine Levels and Cerebrovascular and Neurodegenerative Diseases | Weishi Liu (+9) | 2021 | Frontiers in Genetics |
| 9623 | Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk | Joshua Chiou (+19) | 2021 | Nature Genetics |
| 9624 | Phenotypically independent profiles relevant to mental health are genetically correlated | Daniel Roelfs (+7) | 2021 | Translational Psychiatry |
| 12875 | Healthy lifestyles, genetic modifiers, and colorectal cancer risk: a prospective cohort study in the UK Biobank | Jungyoon Choi (+4) | 2021 | American Journal of Clinical Nutrition |
| 3927 | A Polygenic Risk Score to Predict Future Adult Short Stature Among Children | Tianyuan Lu (+8) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 4685 | Dietary Habit Is Associated with Depression and Intelligence: An Observational and Genome-Wide Environmental Interaction Analysis in the UK Biobank Cohort | Bolun Cheng (+11) | 2021 | Nutrients |
| 5534 | Phenotype discovery from population brain imaging | Weikang Gong (+2) | 2021 | Medical Image Analysis |
| 5615 | Prospective analyses of testosterone and sex hormone-binding globulin with the risk of 19 types of cancer in men and postmenopausal women in UK Biobank | Eleanor L. Watts (+5) | 2021 | International Journal of Cancer |
| 9621 | Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: U.K. Biobank 18,608 example | Ivan I. Maximov (+7) | 2021 | Human Brain Mapping |
| 3994 | Advances in understanding the pathogenesis of hereditary macrothrombocytopenia | Janine Collins (+4) | 2021 | British Journal of Haematology |
| 9620 | Model-based assessment of replicability for genome-wide association meta-analysis | Daniel McGuire (+11) | 2021 | Nature Communications |
| 4854 | Fatty Liver Index and Development of Cardiovascular Disease: Findings from the UK Biobank | Biyao Zou (+4) | 2021 | Digestive Diseases and Sciences |
| 5125 | Hepatic Steatosis, Rather Than Underlying Obesity, Increases the Risk of Infection and Hospitalization for COVID-19 | Adriana Roca-Fernández (+7) | 2021 | Frontiers in Medicine |
| 5573 | Polygenic risk score, healthy lifestyles, and risk of incident depression | Zhi Cao (+6) | 2021 | Translational Psychiatry |
| 4193 | Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank | Charlotte A. Dennison (+9) | 2021 | PLOS ONE |
| 4246 | Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank | Anna E. Fürtjes (+4) | 2021 | Psychological Medicine |
| 4442 | Causal effects of gallstone disease on risk of gastrointestinal cancer in Chinese | Yuanjie Pang (+15) | 2021 | British Journal of Cancer |
| 5532 | Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study | Shan-Shan Dong (+12) | 2021 | Genome Medicine |
| 9619 | Using Mendelian randomization study to assess the renal effects of antihypertensive drugs | Jie V. Zhao (+1) | 2021 | BMC Medicine |
| 3905 | A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity | Zhaozhong Zhu (+23) | 2021 | European Respiratory Journal |
| 4649 | Describing a new food group classification system for UK biobank: analysis of food groups and sources of macro- and micronutrients in 208,200 participants | Carmen Piernas (+10) | 2021 | European Journal of Nutrition |
| 5271 | Investigating Pleiotropy Between Depression and Autoimmune Diseases Using the UK Biobank | Kylie P. Glanville (+4) | 2021 | Biological Psychiatry Global Open Science |
| 5283 | Is neuroticism differentially associated with risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia? | Antonio Terracciano (+9) | 2021 | Journal of Psychiatric Research |
| 5582 | Poor Metabolic Health Increases COVID-19-Related Mortality in the UK Biobank Sample | Filip Morys (+1) | 2021 | Frontiers in Endocrinology |
| 5768 | Socioeconomic Inequalities and Ethnicity Are Associated with a Positive COVID-19 Test among Cancer Patients in the UK Biobank Cohort | Shing Fung Lee (+4) | 2021 | Cancers |
| 3523 | Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci | Michael Francis (+6) | 2021 | PLOS Genetics |
| 4031 | All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes | Alice E. Hughes (+9) | 2021 | Wellcome Open Research |
| 5162 | Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis | Ryan S. Dhindsa (+25) | 2021 | Communications Biology |
| 5859 | The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis | M. Yldau van der Ende (+5) | 2021 | Scientific Reports |
| 3850 | 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans | Ida E. Sønderby (+143) | 2021 | Translational Psychiatry |
| 4481 | Childhood obesity and multiple sclerosis: A Mendelian randomization study | Adil Harroud (+7) | 2021 | Multiple Sclerosis Journal |
| 4887 | Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts | Chiara Fabbri (+12) | 2021 | Molecular Psychiatry |
| 5059 | Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments | Josefin Werme (+3) | 2021 | Translational Psychiatry |
| 5361 | Meat consumption and risk of incident dementia: cohort study of 493,888 UK Biobank participants | Huifeng Zhang (+5) | 2021 | American Journal of Clinical Nutrition |
| 5399 | Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank | Rainer Malik (+7) | 2021 | Alzheimer's & Dementia |
| 5987 | Vegetarians, fish, poultry, and meat-eaters: who has higher risk of cardiovascular disease incidence and mortality? A prospective study from UK Biobank | Petermann-Rocha F et al. | 2021 | Eur Heart J |
| 4391 | Brain age prediction: A comparison between machine learning models using region- and voxel-based morphometric data | Lea Baecker (+9) | 2021 | Human Brain Mapping |
| 5053 | Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank | Helena R. R. Wells (+4) | 2021 | Scientific Reports |
| 5970 | Using Wearable Activity Trackers to Predict Type 2 Diabetes: Machine Learning-Based Cross-sectional Study of the UK Biobank Accelerometer Cohort | Benjamin Lam (+8) | 2021 | JMIR Diabetes |
| 3847 | Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank | Katherine A. Fawcett (+15) | 2021 | ERJ Open Research |
| 4279 | Associations of behaviors, biological phenotypes and cardiovascular health with risks of stroke and stroke subtypes: A prospective cohort study | Zhi Cao (+8) | 2021 | EClinicalMedicine |
| 4791 | Estimating the effective sample size in association studies of quantitative traits | Andrey Ziyatdinov (+7) | 2021 | G3: Genes, Genomes, Genetics |
| 5688 | Road traffic noise and cardiovascular disease risk factors in UK Biobank | Zuzana Kupcikova (+4) | 2021 | European Heart Journal |
| 5960 | Using C-JAMP to Investigate Epistasis and Pleiotropy | Konigorski S et al. | 2021 | Methods Mol Biol |
| 7475 | Tensor Dropout for Robust Learning | Arinbjrn Kolbeinsson (+6) | 2021 | IEEE Journal of Selected Topics in Signal Processing |
| 3932 | A powerful subset-based method identifies gene set associations and improves interpretation in UK Biobank | Diptavo Dutta (+6) | 2021 | American Journal of Human Genetics |
| 5539 | Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans | Boguslavskyi A et al. | 2021 | Circulation |
| 9617 | Genome-wide association study on liver function tests in Chinese. | Sun Yidan (+6) | 2021 | Hereditas (Beijing) |
| 4095 | Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model | Hung RJ et al. | 2021 | Cancer Res |
| 5809 | The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank | Rhonda S. Arthur (+3) | 2021 | British Journal of Cancer |
| 5855 | The genetic architecture of structural left-right asymmetry of the human brain | Zhiqiang Sha (+7) | 2021 | Nature Human Behaviour |
| 4655 | Detecting Parkinson's Disease from Wrist-Worn Accelerometry in the U.K. Biobank | James R. Williamson (+3) | 2021 | Sensors |
| 9616 | Deep longitudinal phenotyping of wearable sensor data reveals independent markers of longevity, stress, and resilience | Timothy V Pyrkov (+2) | 2021 | Aging |
| 4859 | Fitness, Fatness, and Mortality in Men and Women From the UK Biobank: Prospective Cohort Study | Jakob Tarp (+5) | 2021 | Journal of the American Heart Association |
| 5702 | Selection into shift work is influenced by educational attainment and body mass index: a Mendelian randomization study in the UK Biobank | Iyas Daghlas (+9) | 2021 | International Journal of Epidemiology |
| 3867 | A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes | Tatsuhiko Naito (+6) | 2021 | Nature Communications |
| 4924 | Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study | Shuai Yuan (+3) | 2021 | European Journal of Epidemiology |
| 4033 | Allele frequency of variants reported to cause adenine phosphoribosyltransferase deficiency | Hrafnhildur L. Runolfsdottir (+13) | 2021 | European Journal of Human Genetics |
| 4198 | Association of Genetically Predicted Serum Estradiol With Risk of Thromboembolism in Men: A Mendelian Randomization Study | Maria Nethander (+3) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 4444 | Causal Effects of Homocysteine, Folate, and Cobalamin on Kidney Function: A Mendelian Randomization Study | Sehoon Park (+12) | 2021 | Nutrients |
| 5476 | Novel approach for parallelizing pairwise comparison problems as applied to detecting segments identical by decent in whole-genome data | Emmanuel Sapin (+1) | 2021 | Bioinformatics |
| 4125 | Association Between Alopecia Areata and Natural Hair Color Among White Individuals | Yousaf A et al. | 2021 | JAMA Dermatol |
| 4223 | Association of premature menopause with incident pulmonary hypertension: A cohort study | Michael C. Honigberg (+6) | 2021 | PLOS ONE |
| 12876 | Genome-wide polygenic risk score for retinopathy of type 2 diabetes | Iain S Forrest (+13) | 2021 | Human Molecular Genetics |
| 9615 | Genetic discovery and risk characterization in type 2 diabetes across diverse populations | Linda M. Polfus (+56) | 2021 | Human Genetics and Genomics Advances |
| 3996 | Adverse cardiovascular magnetic resonance phenotypes are associated with greater likelihood of incident coronavirus disease 2019: findings from the UK Biobank | Zahra Raisi-Estabragh (+13) | 2021 | Aging Clinical and Experimental Research |
| 5743 | Shift work is associated with increased risk of COVID-19: Findings from the UK Biobank cohort | Yaqoot Fatima (+6) | 2021 | Journal of Sleep Research |
| 8172 | Characterisation, identification, clustering, and classification of disease | A. J. Webster (+4) | 2021 | Scientific Reports |
| 12877 | Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS | Wouter J. Peyrot (+1) | 2021 | Nature Genetics |
| 3853 | A Biomarker-based Biological Age in UK Biobank: Composition and Prediction of Mortality and Hospital Admissions | Mei Sum Chan (+7) | 2021 | The Journals of Gerontology Series A |
| 4862 | Frailty and comorbidity in predicting community COVID-19 mortality in the U.K. Biobank: The effect of sampling | Jonathan K. L. Mak (+4) | 2021 | Journal of the American Geriatrics Society |
| 5422 | Multi-Drug Featurization and Deep Learning Improve Patient-Specific Predictions of Adverse Events | Ioannis N. Anastopoulos (+3) | 2021 | International Journal of Environmental Research and Public Health |
| 5784 | Subsampling Technique to Estimate Variance Component for UK-Biobank Traits | Ting Xu (+4) | 2021 | Frontiers in Genetics |
| 4375 | Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study | Milad Nazarzadeh (+8) | 2021 | Genome Medicine |
| 4560 | Common genetic variants with fetal effects on birth weight are enriched for proximity to genes implicated in rare developmental disorders | Robin N Beaumont (+3) | 2021 | Human Molecular Genetics |
| 5060 | Genome-wide haplotype association study in imaging genetics using whole-brain sulcal openings of 16,304 UK Biobank subjects | Slim Karkar (+8) | 2021 | European Journal of Human Genetics |
| 5830 | The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect | Ruth K. G. Topless (+10) | 2021 | Arthritis Research & Therapy |
| 7520 | The limits of normal approximation for adult height | Sergei A. Slavskii (+6) | 2021 | European Journal of Human Genetics |
| 5846 | The effects of eight serum lipid biomarkers on age-related macular degeneration risk: a Mendelian randomization study | Han X et al. | 2021 | Int J Epidemiol |
| 12878 | Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank | Kevin S. O'Connell (+12) | 2021 | Psychological Medicine |
| 3433 | Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection | Hilser JR et al. | 2021 | J Lipid Res |
| 4151 | Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline | Filip Morys (+2) | 2021 | The Journal of Clinical Endocrinology & Metabolism |
| 5061 | Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population | Robert W. Read (+6) | 2021 | Frontiers in Genetics |
| 5239 | Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis | Trinder M et al. | 2021 | Circulation |
| 5545 | Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort | Carolin V. Schneider (+3) | 2021 | JHEP Reports |
| 9564 | Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder | Roberto Bonelli (+12) | 2021 | Communications Biology |
| 9565 | Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study | Keren Papier (+8) | 2021 | BMC Medicine |
| 3432 | Genome-wide analysis identifies novel susceptibility loci for myocardial infarction | Hartiala JA et al. | 2021 | Eur Heart J |
| 3791 | Exploring the causal pathway from bilirubin to CVD and diabetes in the UK biobank cohort study: Observational findings and Mendelian randomization studies | Hou L et al. | 2021 | Atherosclerosis |
| 3879 | A genome wide association study for lung function in the Korean population using an exome array | Lee KS et al. | 2021 | Korean J Intern Med |
| 3968 | Accelerometer-measured physical activity and functional behaviours among people on dialysis | Nawab KA et al. | 2021 | Clin Kidney J |
| 4556 | Common drugs, vitamins, nutritional supplements and COVID-19 mortality | Steven Lehrer (+1) | 2021 | International Journal of Functional Nutrition |
| 4561 | Common Genetic Variation in MC4R Does Not Affect Atherosclerotic Plaque Phenotypes and Cardiovascular Disease Outcomes | Lisanne L. Blauw (+12) | 2021 | Journal of Clinical Medicine |
| 4597 | Considerations for diagnostic COVID-19 tests | Vandenberg O et al. | 2021 | Nat Rev Microbiol |
| 4925 | Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women | Maxine Sun (+11) | 2021 | The Pharmacogenomics Journal |
| 5089 | Gluten Intake and All-Cause and Cause-Specific Mortality: Prospective Findings from the UK Biobank | Inken Behrendt (+2) | 2021 | Journal of Nutrition |
| 5111 | Habitual Sleep Duration, Daytime Napping, and Dietary Intake: A Mendelian Randomization Study | Alimenti K et al. | 2021 | Curr Dev Nutr |
| 5141 | Higher tea consumption is associated with decreased risk of small vessel stroke | Wang M et al. | 2021 | Clin Nutr |
| 5282 | Is Cohort Representativeness Passé? Poststratified Associations of Lifestyle Risk Factors with Mortality in the UK Biobank | Stamatakis E et al. | 2021 | Epidemiology |
| 5700 | Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort | Cathy Wyse (+4) | 2021 | iScience |
| 5798 | Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study | Duckworth A et al. | 2021 | Lancet Respir Med |
| 9562 | Tumor Mutational Burden Is Polygenic and Genetically Associated with Complex Traits and Diseases | Xiwei Sun (+8) | 2021 | Cancer Research |
| 9563 | A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus | Alison J. Hardcastle (+61) | 2021 | Communications Biology |
| 12879 | GWAS Identifies LINC01184/SLC12A2 as a Risk Locus for Skin and Soft Tissue Infections | Tormod Rogne (+15) | 2021 | Journal of Investigative Dermatology |
| 12880 | One size does not fit all. Genomics differentiates among anorexia nervosa, bulimia nervosa, and binge-eating disorder | Christopher Hübel (+6) | 2021 | International Journal of Eating Disorders |
| 4310 | Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort | Binbin Lei (+13) | 2021 | Sleep |
| 4624 | Cross-sex shifts in two brain imaging phenotypes and their relation to polygenic scores for same-sex sexual behavior: A study of 18,645 individuals from the UK Biobank | Christoph Abé (+7) | 2021 | Human Brain Mapping |
| 5223 | Incorporating both genetic and tobacco smoking data to identify high-risk smokers for lung cancer screening | Guochong Jia (+4) | 2021 | Carcinogenesis |
| 5491 | Obesity, walking pace and risk of severe COVID-19 and mortality: analysis of UK Biobank | Thomas Yates (+6) | 2021 | International Journal of Obesity |
| 7442 | A molecular quantitative trait locus map for osteoarthritis | Julia Steinberg (+14) | 2021 | Nature Communications |
| 5277 | Investigation of associations between retinal microvascular parameters and albuminuria in UK Biobank: a cross-sectional case-control study | Euan N. Paterson (+7) | 2021 | BMC Nephrology |
| 5366 | Mendelian pathway analysis of laboratory traits reveals distinct roles for ciliary subcompartments in common disease pathogenesis | Theodore George Drivas (+3) | 2021 | American Journal of Human Genetics |
| 7630 | Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption | Michelle M McDonald (+46) | 2021 | Cell |
| 4268 | Associations between occupation and heavy alcohol consumption in UK adults aged 40-69 years: a cross-sectional study using the UK Biobank | Andrew Thompson (+1) | 2021 | BMC Public Health |
| 5062 | Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries | Puya Gharahkhani (+78) | 2021 | Nature Communications |
| 5811 | The association of prediagnostic circulating levels of cardiometabolic markers, testosterone and sex hormone-binding globulin with risk of breast cancer among normal weight postmenopausal women in the UK Biobank | Rhonda S. Arthur (+2) | 2021 | International Journal of Cancer |
| 9561 | Apolipoprotein B is an insufficient explanation for the risk of coronary disease associated with lipoprotein(a) | Mark Trinder (+4) | 2021 | Cardiovascular Research |
| 4344 | Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations | Fernando Pires Hartwig (+4) | 2021 | International Journal of Epidemiology |
| 4377 | Body composition and risk of gastric cancer: A population-based prospective cohort study | An-Ran Liu (+13) | 2021 | Cancer Medicine |
| 4714 | Diurnal Physical Activity Patterns across Ages in a Large UK Based Cohort: The UK Biobank Study | Julia Wrobel (+2) | 2021 | Sensors |
| 5146 | Homozygosity for rs17775810 Minor Allele Associated With Reduced Mortality of COVID-19 in the UK Biobank Cohort | Steven Lehrer (+1) | 2021 | In Vivo |
| 5603 | Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants | Joseph A. Johnston (+5) | 2021 | PLOS ONE |
| 5769 | Socioeconomic risk factors and age-related macular degeneration in the UK Biobank study | Yip JLY et al. | 2021 | BMJ Open Ophthalmol |
| 5218 | Imputed gene expression risk scores: a functionally informed component of polygenic risk | Oliver Pain (+9) | 2021 | Human Molecular Genetics |
| 5177 | Identification of Three Loci Associated with Achilles Tendon Injury Risk from a Genome-wide Association Study | STUART K. KIM (+3) | 2021 | Medicine & Science in Sports & Exercise |
| 7335 | GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression | Yeda Wu (+5) | 2021 | Nature Communications |
| 9559 | Widespread signatures of natural selection across human complex traits and functional genomic categories | Jian Zeng (+12) | 2021 | Nature Communications |
| 9560 | GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS | Joshua N. Pritikin (+4) | 2021 | Behavior Genetics |
| 5467 | No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis | Mensah-Kane J et al. | 2021 | Front Genet |
| 9555 | Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality | Frank R. Wendt (+15) | 2021 | Neurobiology of Stress |
| 9556 | Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk | Thorhildur Olafsdottir (+38) | 2021 | Cancer Research |
| 9557 | A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy | Astros Th. Skuladottir (+32) | 2021 | Scientific Reports |
| 9558 | Associations between the CADM2 gene, substance use, risky sexual behavior, and self-control: A phenome-wide association study | Rachel M. Arends (+17) | 2021 | Addiction Biology |
| 4606 | Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux | Verbitsky M et al. | 2021 | J Am Soc Nephrol |
| 4051 | An integrated clinical and genetic model for predicting risk of severe COVID-19: A population-based case-control study | Gillian S. Dite (+2) | 2021 | PLOS ONE |
| 4150 | Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort | Karina Patasova (+11) | 2021 | Investigative Ophthalmology & Visual Science |
| 4668 | Development and Validation of Risk Scores for All-Cause Mortality for a Smartphone-Based "General Health Score" App: Prospective Cohort Study Using the UK Biobank | Clift AK et al. | 2021 | JMIR Mhealth Uhealth |
| 9554 | Personalized genealogical history of UK individuals inferred from biobank-scale IBD segments | Ardalan Naseri (+8) | 2021 | BMC Biology |
| 12881 | Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals | Kathryn E. Kemper (+8) | 2021 | Nature Communications |
| 3743 | Time-Dependent Effects of Oral Contraceptive Use on Breast, Ovarian, and Endometrial Cancers | Torgny Karlsson (+4) | 2021 | Cancer Research |
| 4614 | COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors | Joshua Elliott (+7) | 2021 | European Journal of Epidemiology |
| 5104 | GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background | Nasa Sinnott-Armstrong (+3) | 2021 | eLife |
| 9553 | Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes | Jeremy Schwartzentruber (+12) | 2021 | Nature Genetics |
| 12882 | Dercum's disease: estimating the prevalence of a rare painful loose connective tissue disease | Natalie Munguia (+3) | 2021 | Future Rare Diseases |
| 5398 | Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study | Wartolowska KA et al. | 2021 | Eur Heart J |
| 4618 | Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts | Rebecca E. Graff (+20) | 2021 | Nature Communications |
| 4050 | An Improved Genome-Wide Polygenic Score Model for Predicting the Risk of Type 2 Diabetes | Wei Liu (+4) | 2021 | Frontiers in Genetics |
| 9552 | Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism | Yurong Cheng (+13) | 2021 | Nature Communications |
| 12883 | Lung function and cardiovascular disease: a two-sample Mendelian randomisation study | Daniel H. Higbee (+4) | 2021 | European Respiratory Journal |
| 12884 | Changes over 15 years in the contribution of adiposity and smoking to deaths in England and Scotland | Frederick K. Ho (+6) | 2021 | BMC Public Health |
| 7476 | Single nucleotide polymorphisms in key aging pathways, and phenotypic markers of frailty are associated with increased odds of hospital admission with COVID-19 | Dr Greg Scutt (+1) | 2021 | Journal of Infection |
| 7631 | Genetic determinants of daytime napping and effects on cardiometabolic health | Hassan S. Dashti (+13) | 2021 | Nature Communications |
| 8190 | Identifying Myocardial Infarction Using Hierarchical Template Matching-Based Myocardial Strain: Algorithm Development and Usability Study | Jayendra Maganbhai Bhalodiya (+7) | 2021 | JMIR Medical Informatics |
| 9551 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Daniel Taliun (+188) | 2021 | Nature |
| 4928 | Genetic predictors of participation in optional components of UK Biobank | Jessica Tyrrell (+8) | 2021 | Nature Communications |
| 5788 | Survival analysis on rare events using group-regularized multi-response Cox regression | Ruilin Li (+6) | 2021 | Bioinformatics |
| 5571 | Polygenic risk modeling with latent trait-related genetic components | Matthew Aguirre (+5) | 2021 | European Journal of Human Genetics |
| 5907 | Thyroid function, sex hormones and sexual function: a Mendelian randomization study | Alisa D. Kjaergaard (+11) | 2021 | European Journal of Epidemiology |
| 4169 | Association between Toxoplasma gondii seropositivity and serointensity and brain volume in adults: A cross-sectional study | Lance D. Erickson (+3) | 2021 | PLOS ONE |
| 5022 | Genome-Wide Association Studies-Based Machine Learning for Prediction of Age-Related Macular Degeneration Risk | Yan Q et al. | 2021 | Transl Vis Sci Technol |
| 5050 | Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology | Vincent L. Chen (+10) | 2021 | Nature Communications |
| 5436 | Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank | Glanville KP et al. | 2021 | BJPsych Open |
| 9550 | Developing and validating COVID-19 adverse outcome risk prediction models from a bi-national European cohort of 5594 patients | Espen Jimenez-Solem (+34) | 2021 | Scientific Reports |
| 3805 | Early life factors and COVID-19 infection in England: A prospective analysis of UK Biobank participants | Altug Didikoglu (+4) | 2021 | Early Human Development |
| 3827 | Stair climbing and mortality: a prospective cohort study from the UK Biobank | Miguel A. Sanchez-Lastra (+5) | 2021 | Journal of Cachexia Sarcopenia and Muscle |
| 4261 | Associations between human leukocyte antigens and renal function | Marcus Lowe (+8) | 2021 | Scientific Reports |
| 5021 | Genome-wide association studies of low back pain and lumbar spinal disorders using electronic health record data identify a locus associated with lumbar spinal stenosis | Pradeep Suri (+12) | 2021 | Pain |
| 5433 | Multi-omic and multi-species meta-analyses of nicotine consumption | Rohan H. C. Palmer (+11) | 2021 | Translational Psychiatry |
| 3893 | A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis | Bell S et al. | 2021 | Commun Biol |
| 7477 | Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data | Jianchang Hu (+4) | 2021 | Human Genomics |
| 7478 | Nontrivial Replication of Loci Detected by Multi-Trait Methods | Zheng Ning (+12) | 2021 | Frontiers in Genetics |
| 7479 | Orthogonal moment diffusion tensor decomposition reveals age-related degeneration patterns in complex fiber architecture | Jordan A Chad (+2) | 2021 | Neurobiology of Aging |
| 12885 | Isolated systolic and diastolic hypertension by the 2017 American College of Cardiology/American Heart Association guidelines and risk of cardiovascular disease: a large prospective cohort study | Fu-Rong Li (+9) | 2021 | Journal of Hypertension |
| 4034 | Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19 | Jingqi Zhou (+3) | 2021 | The Journals of Gerontology Series A |
| 5124 | Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort | Atkins JL et al. | 2021 | J Alzheimers Dis |
| 5293 | Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank | Mengying Wang (+7) | 2021 | European Heart Journal |
| 5600 | Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women | Honigberg MC et al. | 2021 | Circulation |
| 3263 | A gene-level methylome-wide association analysis identifies novel Alzheimer's disease genes | Chong Wu (+4) | 2021 | Bioinformatics |
| 3998 | Adverse muscle composition is linked to poor functional performance and metabolic comorbidities in NAFLD | Linge J et al. | 2021 | JHEP Rep |
| 4546 | Combined association of general and central obesity with incidence and mortality of cancers in 22 sites | Solange Parra-Soto (+6) | 2021 | American Journal of Clinical Nutrition |
| 4706 | Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study | Kappelmann N et al. | 2021 | JAMA Psychiatry |
| 4757 | Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank | Caseras X et al. | 2021 | Br J Psychiatry |
| 4954 | Genetic Variation in Sodium-glucose Cotransporter 2 and Heart Failure | Julius L. Katzmann (+7) | 2021 | Clinical Pharmacology & Therapeutics |
| 5180 | Identifying mismatch repair-deficient colon cancer: near-perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series | Loughrey MB et al. | 2021 | Histopathology |
| 5343 | Low High-Density Lipoprotein Cholesterol and High White Blood Cell Counts: A Mendelian Randomization Study | Harsløf M et al. | 2021 | Arterioscler Thromb Vasc Biol |
| 5391 | Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19 | Shu Li (+5) | 2021 | Aging and Disease |
| 5444 | Multi-trait transcriptome-wide association studies with probabilistic Mendelian randomization | Lu Liu (+4) | 2021 | American Journal of Human Genetics |
| 5605 | Prevalence and determinants of hypertension control among almost 100 000 treated adults in the UK | Tapela N et al. | 2021 | Open Heart |
| 5737 | Sexual Differences in Genetic Predisposition of Coronary Artery Disease | Huang Y et al. | 2021 | Circ Genom Precis Med |
| 5806 | The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank | Milton DC et al. | 2021 | Eur Psychiatry |
| 5951 | Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials | Gill D et al. | 2021 | Hypertension |
| 9548 | Mendelian randomisation with coarsened exposures | Matthew J. Tudball (+7) | 2021 | Genetic Epidemiology |
| 9549 | Elucidating the genetic architecture underlying IGF1 levels and its impact on genomic instability and cancer risk | Stasa Stankovic (+6) | 2021 | Wellcome Open Research |
| 5119 | Health, lifestyle and occupational risks in Information Technology workers | D Lalloo (+4) | 2021 | Occupational Medicine |
| 5247 | Integrated gene-based and pathway analyses using UK Biobank data identify novel genes for chronic respiratory diseases | Wang L et al. | 2021 | Gene |
| 7480 | Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study | Xiaomeng Zhang (+14) | 2021 | British Journal of Cancer |
| 7481 | Genome-scale CRISPR screening for modifiers of cellular LDL uptake | Brian T. Emmer (+5) | 2021 | PLOS Genetics |
| 9547 | Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later | Monica Isgut (+3) | 2021 | Genome Medicine |
| 12886 | Genetic underpinnings of risky behaviour relate to altered neuroanatomy | Gökhan Aydogan (+9) | 2021 | Nature Human Behaviour |
| 7336 | The contribution of X-linked coding variation to severe developmental disorders | Hilary C. Martin (+15) | 2021 | Nature Communications |
| 3700 | Alzheimer's and Parkinson's Diseases Predict Different COVID-19 Outcomes: A UK Biobank Study | Yizhou Yu (+4) | 2021 | Geriatrics |
| 4581 | Comparison of regional brain deficit patterns in common psychiatric and neurological disorders as revealed by big data | Peter Kochunov (+17) | 2021 | NeuroImage Clinical |
| 4736 | Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus | Stephen Burgess (+6) | 2021 | Diabetologia |
| 9546 | Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies | Francesco Mazzarotto (+26) | 2021 | Genetics in Medicine |
| 4172 | Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank | Chua SYL et al. | 2021 | Br J Ophthalmol |
| 5610 | Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank | Ha My T. Vy (+3) | 2021 | PLOS Genetics |
| 5741 | Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect | Rafik Tadros (+69) | 2021 | Nature Genetics |
| 5777 | Statistical Impact of Sample Size and Imbalance on Multivariate Analysis in silico and A Case Study in the UK Biobank. | Xinyuan Zhang (+2) | 2021 | AMIA Annual Symposium Proceedings |
| 4499 | Circulating lipids and glioma risk: results from the UK Biobank, Nurses' Health Study, and Health Professionals Follow-Up Study | David J. Cote (+8) | 2021 | Cancer Causes & Control |
| 4545 | Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance | Yazhou He (+10) | 2021 | International Journal of Cancer |
| 3795 | Causal Effect of the Triglyceride-Glucose Index and the Joint Exposure of Higher Glucose and Triglyceride With Extensive Cardio-Cerebrovascular Metabolic Outcomes in the UK Biobank: A Mendelian Randomization Study | Shucheng Si (+10) | 2021 | Frontiers in Cardiovascular Medicine |
| 5275 | Investigating the effects of genetic risk of schizophrenia on behavioural traits | Adam Socrates (+6) | 2021 | Schizophrenia |
| 5360 | Measures of Adiposity and Risk of Testing Positive for SARS-CoV-2 in the UK Biobank Study | Christensen RAG et al. | 2021 | J Obes |
| 5636 | RAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID | Ardalan Naseri (+4) | 2021 | PLOS Genetics |
| 5664 | Relationships between retinal layer thickness and brain volumes in the UK Biobank cohort | Sharon Y. L. Chua (+13) | 2021 | European Journal of Neurology |
| 5985 | Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease | Andrew A. Crawford (+39) | 2021 | Journal of Human Genetics |
| 9545 | Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk ModelPolygenic Model for Lung Cancer Absolute Risk Trajectory | Rayjean J. Hung (+28) | 2021 | Cancer Research |
| 3880 | A genome-wide association study for shoulder impingement and rotator cuff disease | Stuart K Kim (+3) | 2021 | Journal of Shoulder and Elbow Surgery |
| 9544 | Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank | Lei Gao (+10) | 2021 | Journal of the American Heart Association |
| 7482 | Assessing single-cell transcriptomic variability through density-preserving data visualization | Ashwin Narayan (+2) | 2021 | Nature Biotechnology |
| 9542 | Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power | Elizabeth G. Atkinson (+13) | 2021 | Nature Genetics |
| 9543 | Genetics of 35 blood and urine biomarkers in the UK Biobank | Nasa Sinnott-Armstrong (+22) | 2021 | Nature Genetics |
| 3543 | Oestradiol and the risk of myocardial infarction in women: a cohort study of UK Biobank participants | Sanne A E Peters (+1) | 2021 | International Journal of Epidemiology |
| 5386 | Meta-analysis of sample-level dbGaP data reveals novel shared genetic link between body height and Crohn's disease | Antonio Di Narzo (+10) | 2021 | Human Genetics |
| 3648 | Examining the association between family status and depression in the UK Biobank | Giannelis A et al. | 2021 | J Affect Disord |
| 9541 | Assessing the relationship between monoallelic PRKN mutations and Parkinson's risk | Steven J Lubbe (+13) | 2021 | Human Molecular Genetics |
| 4349 | BIN1 rs744373 SNP and COVID-19 mortality | Steven Lehrer (+1) | 2021 | World Academy of Sciences Journal |
| 4637 | Deep Learning-Based Automated Abdominal Organ Segmentation in the UK Biobank and German National Cohort Magnetic Resonance Imaging Studies | Turkay Kart (+8) | 2021 | Investigative Radiology |
| 9540 | Deep learning identifies partially overlapping subnetworks in the human social brain | Hannah Kiesow (+6) | 2021 | Communications Biology |
| 3926 | Polygenic Risk Score for Low-Density Lipoprotein Cholesterol Is Associated With Risk of Ischemic Heart Disease and Enriches for Individuals With Familial Hypercholesterolemia | Haoyu Wu (+5) | 2021 | Circulation Genomic and Precision Medicine |
| 4371 | Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease | Stephanie Y. Yang (+6) | 2021 | Genome Research |
| 4652 | Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes | Weiyin Zhou (+5) | 2021 | Scientific Reports |
| 5094 | Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks | David Amar (+3) | 2021 | Nature Communications |
| 3965 | Accelerometer measured physical activity and the incidence of cardiovascular disease: Evidence from the UK Biobank cohort study | Rema Ramakrishnan (+7) | 2021 | PLOS Medicine |
| 4120 | Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults | Yuan Zhang (+5) | 2021 | Mechanisms of Ageing and Development |
| 4991 | Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes | Angli Xue (+6) | 2021 | Nature Communications |
| 5262 | Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels | Yixuan Ye (+5) | 2021 | Circulation Genomic and Precision Medicine |
| 5526 | Perinatal photoperiod associations with diabetes and chronotype prevalence in a cross-sectional study of the UK Biobank | Philip Lewis (+4) | 2021 | Chronobiology International |
| 5879 | The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals | Rona J. Strawbridge (+25) | 2021 | Scientific Reports |
| 9538 | Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study | Bhautesh Dinesh Jani (+7) | 2021 | BMC Medicine |
| 9539 | Donor and Recipient Size Matching in Heart Transplantation With Predicted Heart and Lean Body Mass | Robert J H Miller (+11) | 2021 | Seminars in Thoracic and Cardiovascular Surgery |
| 4824 | Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations | Joseph Park (+40) | 2021 | Nature Medicine |
| 4864 | Frailty, sarcopenia, cachexia and malnutrition as comorbid conditions and their associations with mortality: a prospective study from UK Biobank | Fanny Petermann-Rocha (+3) | 2021 | Journal of Public Health |
| 9534 | A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization | Jue-Sheng Ong (+23) | 2021 | Nature Communications |
| 9535 | Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance | Oksana Tsyklauri (+12) | 2021 | EMBO Reports |
| 9536 | Large mosaic copy number variations confer autism risk | Maxwell A. Sherman (+9) | 2021 | Nature Neuroscience |
| 9537 | Associations of six adiposity-related markers with incidence and mortality from 24 cancers - findings from the UK Biobank prospective cohort study | Solange Parra-Soto (+7) | 2021 | BMC Medicine |
| 3737 | Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank | Xikang Fan (+9) | 2021 | European Journal of Epidemiology |
| 7483 | Modular machine learning for Alzheimer's disease classification from retinal vasculature | Jianqiao Tian (+7) | 2021 | Scientific Reports |
| 5469 | No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data | Hasnat A Amin (+1) | 2021 | BMJ Nutrition Prevention & Health |
| 5804 | The association between blood groups and COVID-19 infection: a study from the UK Biobank | J. Zhang (+3) | 2021 | Journal of Internal Medicine |
| 9532 | A cross-platform approach identifies genetic regulators of human metabolism and health | Luca A. Lotta (+33) | 2021 | Nature Genetics |
| 9533 | Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank) | Julie Schoorl (+6) | 2021 | Translational Psychiatry |
| 4262 | Associations between left ventricular function, vascular function and measures of cerebral small vessel disease: a cross-sectional magnetic resonance imaging study of the UK Biobank | Max J. P. van Hout (+5) | 2021 | European Radiology |
| 4713 | Distribution of vitamin D status in the UK: a cross-sectional analysis of UK Biobank | Liang-Yu Lin (+3) | 2021 | BMJ Open |
| 4803 | Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort | Xiao Liang (+8) | 2021 | Molecular Brain |
| 3405 | PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study | Lyall DM et al. | 2021 | Arch Med Sci |
| 7338 | Cardiovascular or mortality risk of controlled hypertension and importance of physical activity | Sehoon Park (+14) | 2021 | Heart |
| 8191 | Reply | Carolin V Schneider (+2) | 2021 | Gastroenterology |
| 3296 | Blood Pressure and Risk of Cardiovascular Disease in UK Biobank | Eric Yuk Fai Wan (+9) | 2021 | Hypertension |
| 3443 | Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction | David V. Conti (+230) | 2021 | Nature Genetics |
| 4988 | Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study | Levin MG et al. | 2021 | JAMA Netw Open |
| 7380 | A comprehensive evaluation of methods for Mendelian randomization using realistic simulations and an analysis of 38 biomarkers for risk of type 2 diabetes | Guanghao Qi (+1) | 2021 | International Journal of Epidemiology |
| 3790 | Genomic risk score provides predictive performance for type 2 diabetes in the UK biobank | Xiaolu Chen (+6) | 2021 | Acta Diabetologica |
| 5697 | SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking | Pavel Hamet (+13) | 2021 | American Journal of Hypertension |
| 3826 | Physical Activity and Mortality Across Levels of Adiposity: A Prospective Cohort Study From the UK Biobank | Sanchez-Lastra MA et al. | 2021 | Mayo Clin Proc |
| 4058 | Analysing electrocardiographic traits and predicting cardiac risk in UK biobank | Julia Ramírez (+7) | 2021 | JRSM Cardiovascular Disease |
| 4361 | Birth weight modifies the relation between adulthood levels of insulin-like growth factor-1 and type 2 diabetes: a prospective cohort study | Geng T et al. | 2021 | BMJ Open Diabetes Res Care |
| 4535 | Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study | Zhou J et al. | 2021 | Brain Behav Immun |
| 4604 | Conventional and Genetic Evidence on the Association between Adiposity and CKD | Zhu P et al. | 2021 | J Am Soc Nephrol |
| 4740 | Drug Response Pharmacogenetics for 200,000 UK Biobank Participants. | Gregory McInnes (+1) | 2021 | Biocomputing |
| 4964 | Genetically Determined Smoking Behavior and Risk of Nontraumatic Subarachnoid Hemorrhage | Acosta JN et al. | 2021 | Stroke |
| 5026 | Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels-Brief Report | Hoekstra M et al. | 2021 | Arterioscler Thromb Vasc Biol |
| 5175 | Identification of significant genes and therapeutic agents for breast cancer by integrated genomics | Xiao Sun (+6) | 2021 | Bioengineered |
| 5347 | Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease: New Insights From a Large National Biobank | Patel AP et al. | 2021 | Arterioscler Thromb Vasc Biol |
| 5464 | Night shift work is associated with an increased risk of asthma | Maidstone RJ et al. | 2021 | Thorax |
| 5490 | Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers | Whitfield JB et al. | 2021 | Am J Gastroenterol |
| 5578 | Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses | Sun L et al. | 2021 | PLoS Med |
| 5654 | Reference interval for albumin-adjusted calcium based on a large UK population | Schini M et al. | 2021 | Clin Endocrinol (Oxf) |
| 5801 | Testing for Interactions Between APOE and Klotho Genotypes on Cognitive, Dementia, and Brain Imaging Metrics in UK Biobank. | Rachana Tank (+5) | 2021 | Journal of Alzheimer's Disease |
| 7438 | Polygenic Risk for Schizophrenia, Brain Structure, and Environmental Risk in UK Biobank | Xingxing Zhu (+6) | 2021 | Schizophrenia Bulletin Open |
| 7484 | Analysis of COVID-19 genetic risk susceptibility using UK Biobank SNP genotype data | Taesung Park (+3) | 2021 | International Journal of Data Mining and Bioinformatics |
