| Title: | Atrial fibrillation and kidney function: a bidirectional Mendelian randomization study |
| Journal: | European Heart Journal |
| Published: | 23 May 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34023889/ |
| DOI: | https://doi.org/10.1093/eurheartj/ehab291 |
| URL: | https://academic.oup.com/eurheartj/article-pdf/42/29/2816/39505987/ehab291.pdf |
| Citations: | 69 (43 in last 2 years) as of 8 Aug 2024 |
Publication 4320
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Abstract
AIMS: The aim of this study was to investigate the causal effects between atrial fibrillation (AF) and kidney function.</p>
METHODS AND RESULTS: We performed a bidirectional summary-level Mendelian randomization (MR) analysis implementing the results from a large-scale genome-wide association study for estimated glomerular filtration rate (eGFR) by the CKDGen (N = 765 348) and AF (N = 588 190) to identify genetic instruments. The inverse variance weighted method was the main MR method used. For replication, an allele score-based MR was performed by individual-level data within a UK Biobank cohort of white British ancestry individuals (N = 337 138). A genetic predisposition to AF was significantly associated with decreased eGFR [for log-eGFR, beta -0.003 (standard error, 0.0005), P < 0.001] and increased risk of chronic kidney disease [beta 0.059 (0.0126), P < 0.001]. The significance remained in MR sensitivity analyses and the causal estimates were consistent when we limited the analysis to individuals of European ancestry. Genetically predicted eGFR did not show a significant association with the risk of AF [beta -0.366 (0.275), P = 0.183]. The results were similar in allele score-based MR, as allele score for AF was significantly associated with reduced eGFR [for continuous eGFR, beta -0.079 (0.021), P < 0.001], but allele score for eGFR did not show a significant association with risk of AF [beta -0.005 (0.008), P = 0.530].</p>
CONCLUSIONS: Our study supports that AF is a causal risk factor for kidney function impairment. However, an effect of kidney function on AF was not identified in this study.</p>
6 Keywords
- Atrial Fibrillation
- Genome-Wide Association Study
- Humans
- Kidney
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
14 Authors
- Sehoon Park
- Soojin Lee
- Yaerim Kim
- Yeonhee Lee
- Min Woo Kang
- Kwangsoo Kim
- Yong Chul Kim
- Seung Seok Han
- Hajeong Lee
- Jung Pyo Lee
- Kwon Wook Joo
- Chun Soo Lim
- Yon Su Kim
- Dong Ki Kim
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