| Title: | High coffee consumption, brain volume and risk of dementia and stroke |
| Journal: | Nutritional Neuroscience |
| Published: | 24 Jun 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34165394/ |
| DOI: | https://doi.org/10.1080/1028415x.2021.1945858 |
| URL: | https://ore.exeter.ac.uk/repository/bitstream/10871/126392/1/FINAL_AcceptedManuscript_NNS.pdf |
| Citations: | 25 (17 in last 2 years) as of 8 Aug 2024 |
Publication 5134
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Coffee is a highly popular beverage worldwide, containing caffeine which is a central nervous system stimulant.</p>
OBJECTIVES: We examined whether habitual coffee consumption is associated with differences in brain volumes or the odds of dementia or stroke.</p>
METHODS: We conducted prospective analyses of habitual coffee consumption on 398,646 UK Biobank participants (age 37-73 years), including 17,702 participants with MRI information. We examined the associations with brain volume using covariate adjusted linear regression, and with odds of dementia (4,333 incident cases) and stroke (6,181 incident cases) using logistic regression.</p>
RESULTS: There were inverse linear associations between habitual coffee consumption and total brain (fully adjusted β per cup -1.42, 95% CI -1.89, -0.94), grey matter (β -0.91, 95% CI -1.20, -0.62), white matter (β -0.51, 95% CI -0.83, -0.19) and hippocampal volumes (β -0.01, 95% CI -0.02, -0.003), but no evidence to support an association with white matter hyperintensity (WMH) volume (β -0.01, 95% CI -0.07, 0.05). The association between coffee consumption and dementia was non-linear (Pnon-linearity = 0.0001), with evidence for higher odds for non-coffee and decaffeinated coffee drinkers and those drinking >6 cups/day, compared to light coffee drinkers. After full covariate adjustment, consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1-2 cups/day (fully adjusted OR 1.53, 95% CI 1.28, 1.83), with less evidence for an association with stroke (OR 1.17, 95% CI 1.00, 1.37, p = 0.055).</p>
CONCLUSION: High coffee consumption was associated with smaller total brain volumes and increased odds of dementia.</p>
11 Keywords
- Adult
- Aged
- Brain
- Caffeine
- Central Nervous System Stimulants
- Dementia
- Humans
- Middle Aged
- Prospective Studies
- Risk Factors
- Stroke
6 Authors
- Kitty Pham
- Anwar Mulugeta
- Ang Zhou
- John T. O'Brien
- David J. Llewellyn
- Elina Hyppönen
Enabling scientific discoveries that improve human health