| Title: | Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 1 Dec 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34582556/ |
| DOI: | https://doi.org/10.1093/ajcn/nqab298 |
| URL: | https://academic.oup.com/ajcn/article-pdf/114/6/2043/41395150/nqab298.pdf |
| Citations: | 46 (34 in last 2 years) as of 8 Aug 2024 |
Publication 4677
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Abstract
BACKGROUND: Epidemiological evidence remains conflicting regarding diet and risk of lung cancer.</p>
OBJECTIVES: We sought to systematically investigate whether dietary factors are associated with the risk of incident lung cancer in the UK Biobank.</p>
METHODS: A total of 416,588 participants (54% women) from the UK Biobank were included in the present study. Based on baseline data from FFQs, 3 main dietary patterns were identified by using principal component analysis. Cox proportional hazards models were used to investigate the association of individual food groups and dietary patterns with lung cancer risk.</p>
RESULTS: During a median follow-up of 7.13 y, 1782 incident lung cancer cases were documented. The association analysis showed high intake of red meat and processed meat was associated with an increased risk of lung cancer (HRper 50 g/d: 1.36; 95% CI: 1.13, 1.65 for red meat; HRper 25 g/d: 1.30; 95% CI: 1.10, 1.53 for processed meat). However, the consumption of fruits (HRper 100 g/d: 0.90; 95% CI: 0.84, 0.95), vegetables (HRper 100 g/d: 0.89; 95% CI: 0.81, 0.99), breakfast cereals (HRper 50 g/d: 0.81; 95% CI: 0.74, 0.89), and dietary fiber (HRper 5 g/d: 0.76; 95% CI: 0.69, 0.84) was inversely associated with the risk of lung cancer. For the dietary pattern analysis [quartile (Q) comparison], high adherence to the Prudent pattern (HRQ4 compared with Q1: 0.84; 95% CI: 0.73, 0.96) was associated with a lower risk of lung cancer, whereas the Western pattern (HRQ4 compared with Q1: 1.27; 95% CI: 1.11, 1.46) was associated with a higher risk of lung cancer.</p>
CONCLUSIONS: Our study indicated that a diet characterized by high intake of fruits, vegetables, breakfast cereals, and dietary fiber, as well as low intake of red meat and processed meat, was associated with a lower risk of lung cancer.</p>
12 Keywords
- Biological Specimen Banks
- Cohort Studies
- Diet
- Dietary Fiber
- Female
- Humans
- Lung Neoplasms
- Male
- Prospective Studies
- Risk Factors
- United Kingdom
- Vegetables
18 Authors
- Xiaoxia Wei
- Chen Zhu
- Mengmeng Ji
- Jingyi Fan
- Junxing Xie
- Yanqian Huang
- Xiangxiang Jiang
- Jing Xu
- Rong Yin
- Lingbin Du
- Yuzhuo Wang
- Juncheng Dai
- Guangfu Jin
- Lin Xu
- Zhibin Hu
- Hongbing Shen
- Meng Zhu
- Hongxia Ma
Enabling scientific discoveries that improve human health