| Title: | Association between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank |
| Journal: | British Journal of Cancer |
| Published: | 31 May 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34059803/ |
| DOI: | https://doi.org/10.1038/s41416-021-01443-5 |
| URL: | https://www.nature.com/articles/s41416-021-01443-5.pdf |
| Citations: | 5 (1 in last 2 years) as of 8 Aug 2024 |
Publication 4156
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundPhysical activity has been positively related to malignant melanoma. However, that association may be confounded by ultraviolet radiation (UV), a variable closely related to both outdoor physical activity and malignant melanoma. We examined physical activity, grip strength and sedentary behaviour in relation to risk of malignant melanoma, accounting for relevant confounders using data from a prospective cohort study.MethodsIn 350,512 UK Biobank participants aged 38-73 years at baseline, physical activity was assessed with a modified version of the International Physical Activity Questionnaire Short Form, grip strength was measured with a hand dynamometer, and sedentary behaviour was recorded with three specific questions. Multivariable hazard ratios (HR) and corresponding 95% confidence intervals (CI) were estimated using Cox proportional hazards regression.ResultsDuring 7 years of follow-up, 1239 incident malignant melanoma diagnoses were recorded. Physical activity and sedentary behaviour were unrelated to malignant melanoma (HRs 1.01 (95% CI 0.95-1.07) and 1.04 (95% CI 0.97-1.12), respectively), and the initially positive association with grip strength in the basic model (HR 1.23, 95% CI 1.08-1.40) was attenuated after full adjustment (HR 1.10, 95% CI 0.96-1.26).ConclusionPhysical activity, grip strength and sedentary behaviour are not associated with malignant melanoma risk.</p>
7 Authors
- Andrea Weber
- Michael F. Leitzmann
- Anja M. Sedlmeier
- Hansjörg Baurecht
- Carmen Jochem
- Sebastian Haferkamp
- Sebastian E. Baumeister
Enabling scientific discoveries that improve human health