| Title: | Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients |
| Journal: | Alzheimer's & Dementia |
| Published: | 21 Apr 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33881211/ |
| DOI: | https://doi.org/10.1002/alz.12352 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.12352 |
| Citations: | 76 (34 in last 2 years) as of 8 Aug 2024 |
Publication 4640
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Abstract
INTRODUCTION: Dementia has been associated with COVID-19 prevalence, but whether this reflects higher infection, older age of patients, or disease severity remains unclear.</p>
METHODS: We investigated a cohort of 12,863 UK Biobank community-dwelling individuals > 65 years old (1814 individuals ≥ 80 years old) tested for COVID-19. Individuals were stratified by age to account for age as a confounder. Risk factors were analyzed for COVID-19-positive diagnosis, hospitalization, and death.</p>
RESULTS: All-cause dementia, Alzheimer's disease (AD), and Parkinson's disease (PD) were associated with COVID-19-positive diagnosis, and all-cause dementia and AD remained associated in individuals ≥ 80 years old. All-cause dementia, AD, or PD were not risk factors for overall hospitalization, but increased the risk of hospitalization of COVID-19 patients. All-cause dementia and AD increased the risk of COVID-19-related death, and all-cause dementia was uniquely associated with increased death in ≥ 80-year-old patients.</p>
DISCUSSION: All-cause dementia and AD are age-independent risk factors for disease severity and death in COVID-19.</p>
19 Keywords
- Age Factors
- Aged
- Aged, 80 and over
- Alzheimer Disease
- COVID-19
- Comorbidity
- Dementia
- Female
- Hospitalization
- Humans
- Independent Living
- Inpatients
- Male
- Parkinson Disease
- Prevalence
- Prospective Studies
- Risk Factors
- Severity of Illness Index
- United Kingdom
3 Authors
- Ana C. Tahira
- Sergio Verjovski-Almeida
- Sergio T. Ferreira
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