| Title: | Association of mitochondrial DNA copy number with cardiometabolic diseases |
| Journal: | Cell Genomics |
| Published: | 13 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35036986/ |
| DOI: | https://doi.org/10.1016/j.xgen.2021.100006 |
| Citations: | 34 (15 in last 2 years) as of 8 Aug 2024 |
Publication 12671
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Abstract
Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: among younger participants (<65 years of age), each additional 10 years of age was associated with 0.03 standard deviation (s.d.) higher level of mtDNA CN (P = 0.0014) versus a 0.14 s.d. lower level of mtDNA CN (P = 1.82 × 10-13) among older participants (≥65 years). At lower mtDNA CN levels, we found age-independent associations with increased odds of obesity (P = 5.6 × 10-238), hypertension (P = 2.8 × 10-50), diabetes (P = 3.6 × 10-7), and hyperlipidemia (P = 6.3 × 10-5). The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases.</p>
39 Authors
- Xue Liu
- Ryan J. Longchamps
- Kerri L. Wiggins
- Laura M. Raffield
- Lawrence F. Bielak
- Wei Zhao
- Achilleas Pitsillides
- Thomas W. Blackwell
- Jie Yao
- Xiuqing Guo
- Nuzulul Kurniansyah
- Bharat Thyagarajan
- Nathan Pankratz
- Stephen S. Rich
- Kent D. Taylor
- Patricia A. Peyser
- Susan R. Heckbert
- Sudha Seshadri
- L. Adrienne Cupples
- Eric Boerwinkle
- Megan L. Grove
- Nicholas B. Larson
- Jennifer A. Smith
- Ramachandran S. Vasan
- Tamar Sofer
- Annette L. Fitzpatrick
- Myriam Fornage
- Jun Ding
- Adolfo Correa
- Goncalo Abecasis
- Bruce M. Psaty
- James G. Wilson
- Daniel Levy
- Jerome I. Rotter
- Joshua C. Bis
- TOPMed mtDNA Working Group in NHLBI Trans-Omics for Precision Medicine Consortium
- Claudia L. Satizabal
- Dan E. Arking
- Chunyu Liu
1 Application
| Application ID | Title |
|---|---|
| 17731 | A phenome-wide association study of copy number variation |
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