| Title: | Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants |
| Journal: | J Child Psychol Psychiatry |
| Published: | 1 Jul 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32645214/ |
| DOI: | https://doi.org/10.1111/jcpp.13298 |
Publication 3274
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Abstract
Adversity experiences (AEs) are major risk factors for psychiatric illness, and ample evidence suggests that adversity-related changes in brain structure enhance this vulnerability. To achieve greater understanding of the underlying biological pathways, increased convergence among findings is needed. Suggested future directions may benefit from the use of large population samples which may contribute to achieving this goal. We addressed mechanistic pathways by investigating the associations between multiple brain phenotypes and retrospectively reported AEs in early life (child adversity) and adulthood (partner abuse) in a large population sample, using a crosssectional approach.Using a large population cohort, this study demonstrates the value of big datasets in the study of adversity and using automatically preprocessed neuroimaging phenotypes. While retrospective and cross-sectional characteristics limit interpretation, this study demonstrates that self-perceived adversity reports, however nonspecific, may still expose neural consequences, identifiable with increased statistical power.
1 Author
- Gheorghe DA et al.
1 Application
| Application ID | Title |
|---|---|
| 15008 | The impact of smoking, alcohol and adiposity on health outcomes in the UK Biobank |
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