| Title: | Neurological diseases and COVID-19: prospective analyses using the UK Biobank |
| Journal: | Acta Neurologica Belgica |
| Published: | 5 May 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33954931/ |
| DOI: | https://doi.org/10.1007/s13760-021-01693-3 |
| URL: | https://link.springer.com/content/pdf/10.1007/s13760-021-01693-3.pdf |
Publication 3824
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Abstract
COVID-19 (Coronavirus disease-19) may present with neurological signs, but whether people already affected by neurological conditions are at a higher risk of contracting COVID-19 is still not known. We, therefore, aimed to investigate the association of previously diagnosed neurological conditions with COVID-19. 502,536 community-dwelling UK Biobank participants (54.4% male, mean age 56.6 ± 10.3 years) were included. Among these, 57,463 participants had a diagnosis of neurological conditions (11.43%) and a total of 1326 COVID-19-positive cases were identified (0.26%). Neurological conditions were identified through medical history and linkage to data on hospital admissions (ICD-10 code G00-G99). COVID-19 presence was diagnosed using the data provided by Public Health England. The association of previous diagnosis of neurological conditions with COVID-19 was evaluated through logistic regressions, adjusted for potential confounders, reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Nerve, nerve root and plexus disorders (G50-G59) were the most common conditions identified. The presence of COVID-19 was almost doubled in neurological conditions compared to the general population (0.45 vs. 0.24%, p < 0.0001). Previously diagnosed neurological conditions were associated with 60% higher odds of COVID-19 positive in the multivariable-adjusted model (OR = 1.6, 95% CI 1.4-1.8). Other degenerative diseases of the nervous system, extrapyramidal and movement disorders, polyneuropathies and other disorders of the peripheral nervous system, cerebral palsy and other paralytic syndromes were significantly associated with a higher odds of COVID-19. The presence of neurological conditions was associated with a significantly higher likelihood of COVID-19 compared to the general population.</p>
10 Authors
- Nicola Veronese
- Lee Smith
- Mario Barbagallo
- Gianluigi Giannelli
- Maria Gabriella Caruso
- Anna Maria Cisternino
- Maria Notarnicola
- Chao Cao
- Thomas Waldhoer
- Lin Yang
1 Application
| Application ID | Title |
|---|---|
| 41245 | Importance of healthy lifestyle on chronic neurological conditions |
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