| Title: | Habitual coffee intake and plasma lipid profile: Evidence from UK Biobank |
| Journal: | Clinical Nutrition |
| Published: | 11 Jan 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33487505/ |
| DOI: | https://doi.org/10.1016/j.clnu.2020.12.042 |
Publication 13715
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Abstract
BACKGROUND & AIMS: There is evidence that long-term heavy coffee consumption may adversely affect individuals' cardiovascular disease (CVD) risk. As hyperlipidemia is a well-established contributor to CVD risk, we investigated the association between habitual coffee intake and plasma lipid profile.</p>
METHODS: We used data from up to 362,571 UK Biobank participants to examine phenotypic associations between self-reported coffee intake and plasma lipid profiles, including low-density-lipoproteins cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (total-C), triglycerides, and apolipoproteins A1 and B (ApoA1 and ApoB). Mendelian randomization (MR) analysis using genetically instrumented coffee intake was used to interrogate the causal nature of coffee-lipid associations.</p>
RESULTS: We observed a positive dose-dependent association between self-reported coffee intake and plasma concentration of LDL-C, ApoB and total-C, with the highest lipid levels seen among participants reported drinking >6 cups/day (Plinear trend≤ 3.24E-55 for all). Consistently, in MR analyses using genetically instrumented coffee intake one cup higher coffee intake was associated with a 0.07 mmol/L (95% CI 0.03 to 0.12), 0.02 g/L (95% CI 0.01 to 0.03), and 0.09 mmol/L (95% CI 0.04 to 0.14) increase in plasma concentration of LDL-C, ApoB, and total-C, respectively.</p>
CONCLUSIONS: Our phenotypic and genetic analyses suggest that long-term heavy coffee consumption may lead to unfavourable lipid profile, which could potentially increase individuals' risk for CVD. These findings may have clinical relevance for people with elevated LDL cholesterol.</p>
17 Keywords
- Adult
- Aged
- Apolipoprotein B-100
- Cholesterol
- Cholesterol, LDL
- Coffee
- Drinking Behavior
- Female
- Genetic Variation
- Humans
- Lipids
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Prospective Studies
- Self Report
- United Kingdom
2 Authors
- Ang Zhou
- Elina Hyppönen
1 Application
| Application ID | Title |
|---|---|
| 20175 | Nutrition, diet and health: examining causal associations and gene-environment interactions |
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