| Title: | Family history of diabetes and risk of SARS-COV-2 in UK Biobank: A prospective cohort study |
| Journal: | Endocrinology Diabetes & Metabolism |
| Published: | 11 Jul 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34505416/ |
| DOI: | https://doi.org/10.1002/edm2.283 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/edm2.283 |
Publication 4851
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Abstract
INTRODUCTION: The aim of this study was to determine risk of being SARS-CoV-2 positive and severe infection (associated with hospitalization/mortality) in those with family history of diabetes.</p>
METHODS: We used UK Biobank, an observational cohort recruited between 2006 and 2010. We compared the risk of being SARS-CoV-2 positive and severe infection for those with family history of diabetes (mother/father/sibling) against those without.</p>
RESULTS: Of 401,268 participants in total, 13,331 tested positive for SARS-CoV-2 and 2282 had severe infection by end of January 2021. In unadjusted models, participants with ≥2 family members with diabetes were more likely to be SARS-CoV-2 positive (risk ratio-RR 1.35; 95% confidence interval-CI 1.24-1.47) and severe infection (RR 1.30; 95% CI 1.04-1.59), compared to those without. The excess risk of being tested positive for SARS-CoV-2 was attenuated but significant after adjusting for demographics, lifestyle factors, multimorbidity and presence of cardiometabolic conditions. The excess risk for severe infection was no longer significant after adjusting for demographics, lifestyle factors, multimorbidity and presence of cardiometabolic conditions, and was absent when excluding incident diabetes.</p>
CONCLUSION: The totality of the results suggests that good lifestyle and not developing incident diabetes may lessen risks of severe infections in people with a strong family of diabetes.</p>
17 Keywords
- Adult
- Aged
- Aged, 80 and over
- Biological Specimen Banks
- COVID-19
- Cohort Studies
- Comorbidity
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Female
- Humans
- Life Style
- Male
- Middle Aged
- Risk
- SARS-CoV-2
- United Kingdom
16 Authors
- Bhautesh Dinesh Jani
- Barbara I. Nicholl
- Peter Hanlon
- Frances S. Mair
- Jason MR. Gill
- Stuart R. Gray
- Carlos A. Celis-Morales
- Frederick K. Ho
- Donald M. Lyall
- Jana J. Anderson
- Claire E. Hastie
- Mark ES. Bailey
- Hamish Foster
- Jill P. Pell
- Paul Welsh
- Naveed Sattar
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