| Title: | Polygenic burden could explain high rates of affective disorders in a community with restricted founder population |
| Journal: | American Journal of Medical Genetics Part B Neuropsychiatric Genetics |
| Published: | 1 Sep 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34632698/ |
| DOI: | https://doi.org/10.1002/ajmg.b.32876 |
Publication 5563
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
This study investigates if genetic factors could contribute to the high rate of mood disorders reported in a U.S. community known to have a restricted early founder population (confirmed here through runs of homozygosity analysis). Polygenic scores (PGSs) for eight common diseases, disorders, or traits, including psychiatric disorders, were calculated in 274 participants (125 mood disorder cases) who each reported three or four grandparents born in the community. Ancestry-matched controls were selected from the UK Biobank (UKB; three sets of N = 1,822 each). The mean PGSs were significantly higher in the community for major depression PRS (p = 2.1 × 10-19 , 0.56 SD units), bipolar disorder (p = 2.5 × 10-15 , 0.56 SD units), and schizophrenia (p = 3.8 × 10-21 , 0.64 SD units). The PGSs were not significantly different between the community participants and UKB controls for the traits of body mass index, Type 2 diabetes, coronary artery disease, and chronotype. The mean PGSs for height were significantly lower in the community sample compared to controls (-0.21 SD units, p = 1.2 × 10-5 ). The results are consistent with enrichment of polygenic risk factors for psychiatric disorders in this community.</p>
6 Authors
- Xiaotong Wang
- Tian Lin
- Loic Yengo
- Julia Sidorenko
- Naomi R. Wray
- Douglas F. Levinson
Enabling scientific discoveries that improve human health