| Title: | Healthy Sleep Patterns and Risk of Incident Arrhythmias |
| Journal: | Journal of the American College of Cardiology |
| Published: | 1 Sep 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34531019/ |
| DOI: | https://doi.org/10.1016/j.jacc.2021.07.023 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454031 |
| Citations: | 72 (53 in last 2 years) as of 8 Aug 2024 |
Publication 12677
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Abstract
BACKGROUND: Emerging evidence has linked sleep behaviors with the risk of cardiac arrhythmias. The various sleep behaviors are typically correlated; however, most of the previous studies only focused on the individual sleep behavior, without considering the overall sleep patterns.</p>
OBJECTIVES: The purpose of this study was to prospectively investigate the associations between a healthy sleep pattern with the risks of cardiac arrhythmias.</p>
METHODS: A total of 403,187 participants from UK Biobank were included. A healthy sleep pattern was defined by chronotype, sleep duration, insomnia, snoring, and daytime sleepiness. Weighted genetic risk score for atrial fibrillation was calculated.</p>
RESULTS: The healthy sleep pattern was significantly associated with lower risks of atrial fibrillation/flutter (AF) (HR comparing extreme categories: 0.71; 95% CI: 0.64-0.80) and bradyarrhythmia (HR: 0.65; 95% CI: 0.54-0.77), but not ventricular arrhythmias, after adjustment for demographic, lifestyle, and genetic risk factors. Compared with individuals with a healthy sleep score of 0-1 (poor sleep group), those with a healthy sleep score of 5 had a 29% and 35% lower risk of developing AF and bradyarrhythmia, respectively. Additionally, the genetic predisposition to AF significantly modified the association of the healthy sleep pattern with the risk of AF (P interaction = 0.017). The inverse association of the healthy sleep pattern with the risk of AF was stronger among those with a lower genetic risk of AF.</p>
CONCLUSIONS: Our results indicate that a healthy sleep pattern is associated with lower risks of AF and bradyarrhythmia, independent of traditional risk factors, and the association with AF is modified by genetic susceptibility.</p>
11 Keywords
- Aged
- Atrial Fibrillation
- Bradycardia
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Assessment
- Sleep
- United Kingdom
7 Authors
- Xiang Li
- Tao Zhou
- Hao Ma
- Tao Huang
- Xiang Gao
- JoAnn E Manson
- Lu Qi
1 Application
| Application ID | Title |
|---|---|
| 29256 | Study of gene-environment interaction and Mendelian randomization of obesity and cardiometabolic risk |
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