| Title: | Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study |
| Journal: | Journal of Thrombosis and Haemostasis |
| Published: | 20 Jul 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34242477/ |
| DOI: | https://doi.org/10.1111/jth.15452 |
| URL: | http://www.jthjournal.org/article/S1538783622021511/pdf |
| Citations: | 5 (1 in last 2 years) as of 8 Aug 2024 |
Publication 5668
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Abstract
BACKGROUND: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of VTE. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID-19.</p>
OBJECTIVES: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors.</p>
METHODS: Cohort study of UK Biobank participants recruited between 2006 and 2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19-related hospital admissions, and COVID-19 deaths. The risk of COVID-19 hospitalization or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for sociodemographic, lifestyle, and comorbid covariates.</p>
RESULTS: After adjustment for sociodemographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with nonfatal community (RR 1.61, 95% CI 1.02-2.54, p = .039), nonfatal hospitalized (RR 1.52, 95% CI 1.06-2.17, p = .024) and severe (hospitalized or fatal) (RR 1.40, 95% CI 1.04-1.89, p = .025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14-2.42, p = .009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66-1.74, p = .786).</p>
CONCLUSION: Our findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.</p>
12 Keywords
- Aged
- Biological Specimen Banks
- COVID-19
- Cohort Studies
- Female
- Humans
- Male
- Risk Factors
- SARS-CoV-2
- United Kingdom
- Venous Thromboembolism
- Venous Thrombosis
19 Authors
- Jana J Anderson
- Frederick K Ho
- Claire L Niedzwiedz
- Srinivasa Vittal Katikireddi
- Carlos Celis-Morales
- Stamatina Iliodromiti
- Paul Welsh
- Pierpaolo Pellicori
- Evangelia Demou
- Claire E Hastie
- Donald M Lyall
- Stuart R Gray
- John F Forbes
- Jason M R Gill
- Daniel F Mackay
- Colin Berry
- John G F Cleland
- Naveed Sattar
- Jill P Pell
Enabling scientific discoveries that improve human health