| Title: | Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort |
| Journal: | Sleep Medicine |
| Published: | 1 Jul 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34343768/ |
| DOI: | https://doi.org/10.1016/j.sleep.2021.05.040 |
Publication 5242
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
STUDY OBJECTIVES: We aim to explore the mechanism of relationship between insomnia and liver metabolism by examining the gene × insomnia interactions.</p>
METHODS: Individual level genotypic and phenotypic data were obtained from the UK Biobank cohort. Regression analysis was first conducted to test the association of insomnia with plasma total bilirubin (TBil; n = 186,793), direct bilirubin (DBil; n = 159,854) and total protein (TP; n = 171,574) in UK Biobank cohort. Second, genome-wide gene-environment interaction study (GWGEIS) was conducted by PLINK 2.0, and FUMA platform was used to identify enriched pathway terms.</p>
RESULTS: In UK Biobank cohort, we found that TP (P < 2.00 × 10-16), DBil (P = 1.72 × 10-3) and TBil (P = 3.38 × 10-5) were significantly associated with insomnia. GWGEIS of both DBil and TBil observed significant G × INSOMNIA effects between insomnia and UDP Glucuronosyltransferase Family 1 (rs6431558, P = 6.26 × 10-11) gene. GWGEIS of TP also detected several significant genes interacting with insomnia, such as KLF15, (rs70940816, P = 6.77 × 10-10) and DOK7, (rs2344205, P = 1.37 × 10-9). Multiple gene ontology (GO) terms were identified for bilirubin, such as GO_URONIC_ACID_METABOLIC_PROCESS (adjusted P = 4.15 × 10-26).</p>
CONCLUSION: Our study results suggested negative associations between insomnia and DBil and TBil; and a positive association between insomnia and TP.</p>
6 Keywords
- Bilirubin
- Biological Specimen Banks
- Cohort Studies
- Humans
- Sleep Initiation and Maintenance Disorders
- United Kingdom
17 Authors
- Xiaomeng Chu
- Li Liu
- Jing Ye
- Yan Wen
- Ping Li
- Bolun Cheng
- Shiqiang Cheng
- Lu Zhang
- Xin Qi
- Mei Ma
- Chujun Liang
- Om Prakash Kafle
- Cuiyan Wu
- Sen Wang
- Xi Wang
- Yujie Ning
- Feng Zhang
Enabling scientific discoveries that improve human health