| Title: | Long-term conditions, multimorbidity, lifestyle factors and change in grip strength over 9 years of follow-up: Findings from 44,315 UK biobank participants |
| Journal: | Age and Ageing |
| Published: | 15 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34657960/ |
| DOI: | https://doi.org/10.1093/ageing/afab195 |
| URL: | https://academic.oup.com/ageing/article-pdf/50/6/2222/41119487/afab195.pdf |
| Citations: | 17 (7 in last 2 years) as of 8 Aug 2024 |
Publication 5339
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Abstract
BACKGROUND: Weak grip strength is associated with a range of adverse health outcomes and an accelerated decline in grip strength confers an even greater risk. The factors associated with change in grip strength in mid-life remain to be fully determined.</p>
METHODS: We used data from 44,315 UK Biobank participants who had grip strength measured at baseline (2006-10) and a subsequent visit approximately nine years later. At baseline, participants' long-term conditions (LTCs) were categorised against a hierarchy, with multimorbidity characterised by the number of LTC categories. Lifestyle factors were assessed. Change in grip strength was grouped into four patterns: decline, stable low, stable high or reference (no change or increase) and used as the outcome in multinomial logistic regression.</p>
RESULTS: Most LTC categories were associated with adverse patterns of change in grip strength (stable low and/or decline): for example, musculoskeletal/trauma conditions were associated with an increased risk of the stable low pattern (Relative Risk Ratio [RRR] = 1.63; 95% confidence interval [CI]: 1.49-1.79). Multimorbidity and lifestyle factors had independent associations with grip strength change. Those with 3+ categories of LTCs were more likely to experience decline in grip strength (RRR = 1.18; 95% CI: 1.08-1.28) compared to those with none. Low physical activity was associated with adverse patterns of grip strength, while raised body mass index (BMI) had divergent associations.</p>
CONCLUSIONS: Individuals living with multimorbidity and those with lifestyle risk factors such as low physical activity are at increased risk of low muscle strength and the loss of strength over time.</p>
6 Keywords
- Biological Specimen Banks
- Hand Strength
- Humans
- Life Style
- Multimorbidity
- United Kingdom
8 Authors
- Christopher Hurst
- James C Murray
- Antoneta Granic
- Susan J Hillman
- Rachel Cooper
- Avan Aihie Sayer
- Sian M Robinson
- Richard M Dodds
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