| Title: | Adherence to a healthy sleep pattern is associated with lower risks of all-cause, cardiovascular and cancer-specific mortality |
| Journal: | Journal of Internal Medicine |
| Published: | 2 Aug 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34237797/ |
| DOI: | https://doi.org/10.1111/joim.13367 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688171 |
Publication 3983
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Abstract
BACKGROUND: Individual unhealthy sleep behaviours have been associated with increased risks of all-cause mortality and deaths due to cardiovascular disease (CVD) or cancer. The evidence regarding the association of sleep patterns with these risks is limited. OBJECTIVE: To examine the associations of sleep patterns with all-cause, CVD and cancer mortality in a large prospective cohort. METHODS: This prospective cohort study included 283,443 adults from UK Biobank without CVD and cancer at baseline. We created a healthy sleep score and sleep patterns combining five individual sleep behaviours. RESULTS: During a mean (standard deviation) of 8.9 (1.1) years (2.5 million person-years) of follow up, a total of 7936 all-cause deaths, 762 CVD-caused deaths, and 4540 cancer-caused deaths occurred during follow up. One point increase of the healthy sleep score was associated with a 4-11% lower risk of all-cause mortality (Hazard Ratio [HR], 0.94; 95% CI, 0.92-0.96), CVD mortality (HR, 0.89; 95% CI, 0.83-0.95) and cancer mortality (HR, 0.96; 95% CI, 0.93-0.99), with adjustment for age, sex, assessment centres, smoking status, alcohol intake status, socioeconomic status and physical activity. Compared with participants with an unfavourable sleep pattern, those with a favourable sleep pattern had 24-42% lower risks of all-cause and CVD mortality. The association with all-cause mortality tended to be stronger among underweight participants and those with insufficient physical activity. CONCLUSIONS: A healthy sleep pattern was associated with lower risks of all-cause mortality and mortality from CVD and cancer. Our findings highlight the importance of improving overall sleep behaviours in lowering mortality.8 Authors
- Tao Zhou
- Yu Yuan
- Qiaochu Xue
- Xiang Li
- Mengying Wang
- Hao Ma
- Yoriko Heianza
- Lu Qi
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