| Title: | Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank |
| Journal: | European Heart Journal |
| Published: | 2 Feb 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33527989/ |
| DOI: | https://doi.org/10.1093/eurheartj/ehaa1031 |
| URL: | https://academic.oup.com/eurheartj/article-pdf/42/16/1582/37767241/ehaa1031.pdf |
| Citations: | 147 (97 in last 2 years) as of 8 Aug 2024 |
Publication 5293
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
AIMS: Little is known about the relation between the long-term joint exposure to various ambient air pollutants and the incidence of heart failure (HF). We aimed to assess the joint association of various air pollutants with HF risk and examine the modification effect of the genetic susceptibility.</p>
METHODS AND RESULTS: This study included 432 530 participants free of HF, atrial fibrillation, or coronary heart disease in the UK Biobank study. All participants were enrolled from 2006 to 2010 and followed up to 2018. The information on particulate matter (PM) with diameters ≤2.5 µm (PM2.5), ≤10 µm (PM10), and between 2.5 and 10 µm (PM2.5-10) as well as nitrogen oxides (NO2 and NOx) was collected. We newly proposed an air pollution score to assess the joint exposure to the five air pollutants through summing each pollutant concentration weighted by the regression coefficients with HF from single-pollutant models. We also calculated the weighted genetic risk score of HF. During a median of 10.1 years (4 346 642 person-years) of follow-up, we documented 4201 incident HF. The hazard ratios (HRs) [95% confidence interval (CI)] of HF for a 10 µg/m3 increase in PM2.5, PM10, PM2.5-10, NO2, and NOx were 1.85 (1.34-2.55), 1.61 (1.30-2.00), 1.13 (0.80-1.59), 1.10 (1.04-1.15), and 1.04 (1.02-1.06), respectively. We found that the air pollution score was associated with an increased risk of incident HF in a dose-response fashion. The HRs (95% CI) of HF were 1.16 (1.05-1.28), 1.19 (1.08-1.32), 1.21 (1.09-1.35), and 1.31 (1.17-1.48) in higher quintile groups compared with the lowest quintile of the air pollution score (P trend <0.001). In addition, we observed that the elevated risk of HF associated with a higher air pollution score was strengthened by the genetic susceptibility to HF.</p>
CONCLUSION: Our results indicate that the long-term joint exposure to various air pollutants including PM2.5, PM10, PM2.5-10, NO2, and NOx is associated with an elevated risk of incident HF in an additive manner. Our findings highlight the importance to comprehensively assess various air pollutants in relation to the HF risk.</p>
9 Keywords
- Air Pollutants
- Air Pollution
- Biological Specimen Banks
- Environmental Exposure
- Heart Failure
- Humans
- Particulate Matter
- Prospective Studies
- United Kingdom
8 Authors
- Mengying Wang
- Tao Zhou
- Yongze Song
- Xiang Li
- Hao Ma
- Yonghua Hu
- Yoriko Heianza
- Lu Qi
Enabling scientific discoveries that improve human health