| Title: | Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study |
| Journal: | Nutrients |
| Published: | 28 Apr 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33924952/ |
| DOI: | https://doi.org/10.3390/nu13051490 |
| URL: | https://www.mdpi.com/2072-6643/13/5/1490/pdf?version=1621819205 |
| Citations: | 12 (5 in last 2 years) as of 8 Aug 2024 |
Publication 4448
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Abstract
We aimed to investigate the causal effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) on the risk of coronary artery disease (CAD) through Mendelian randomization (MR) analysis. This MR study utilized a genetic instrument developed from previous genome-wide association studies for various serum n-3 and n-6 PUFA levels. First, we calculated the allele scores for genetic predisposition of PUFAs in individuals of European ancestry in the UK Biobank data (N = 337,129). The allele score-based MR was obtained by regressing the allele scores to CAD risks. Second, summary-level MR was performed with the CARDIoGRAMplusC4D data for CAD (N = 184,305). Higher genetically predicted eicosapentaenoic acid and dihomo-gamma-linolenic acid levels were significantly associated with a lower risk of CAD both in the allele-score-based and summary-level MR analyses. Higher allele scores for linoleic acid level were significantly associated with lower CAD risks, and in the summary-level MR, the causal estimates by the pleiotropy-robust MR methods also indicated that higher linoleic acid levels cause a lower risk of CAD. Arachidonic acid showed significant causal estimates for a higher risk of CAD. This study supports the causal effects of certain n-3 and n-6 PUFA types on the risk of CAD.</p>
10 Keywords
- Cohort Studies
- Coronary Artery Disease
- Fatty Acids, Omega-3
- Fatty Acids, Omega-6
- Female
- Humans
- Male
- Mendelian Randomization Analysis
- Middle Aged
- United Kingdom
14 Authors
- Sehoon Park
- Soojin Lee
- Yaerim Kim
- Yeonhee Lee
- Min Woo Kang
- Kwangsoo Kim
- Yong Chul Kim
- Seung Seok Han
- Hajeong Lee
- Jung Pyo Lee
- Kwon Wook Joo
- Chun Soo Lim
- Yon Su Kim
- Dong Ki Kim
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