| Title: | The genetics of testosterone contributes to "femaleness/maleness" of cardiometabolic traits and type 2 diabetes |
| Journal: | International Journal of Obesity |
| Published: | 3 Sep 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34480103/ |
| DOI: | https://doi.org/10.1038/s41366-021-00960-w |
| Citations: | 7 (4 in last 2 years) as of 8 Aug 2024 |
Publication 5858
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Abstract
The genetic architecture of testosterone is highly distinct between sexes. Moreover, obesity is associated with higher testosterone in females but lower testosterone in males. Here, we ask whether male-specific testosterone variants are associated with a male pattern of obesity and type 2 diabetes (T2D) in females, and vice versa. In the UK Biobank, we conducted sex-specific genome-wide association studies and computed polygenic scores for total (PGSTT) and bioavailable testosterone (PGSBT). We tested sex-congruent and sex-incongruent associations between sex-specific PGSTs and metabolic traits, as well as T2D diagnosis. Female-specific PGSBT was associated with an elevated cardiometabolic risk and probability of T2D, in both sexes. Male-specific PGSTT was associated with traits conferring a lower cardiometabolic risk and probability of T2D, in both sexes. We demonstrate the value in considering polygenic testosterone as sex-related continuous traits, in each sex.</p>
5 Authors
- Daniel E. Vosberg
- Nadine Parker
- Jean Shin
- Zdenka Pausova
- Tomáš Paus
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