Category 220
Biological samplesBlood assays ⏵ NMR metabolomics


NMR metabolic biomarkers generated by Nightingale Health. Data is currently available for Phase 1 and Phase 2 of the study, measuring 251 metabolic biomarkers for EDTA plasma samples from approx 280,000 UK Biobank participants.

Metabolic biomarkers were measured from randomly selected EDTA plasma samples (aliquot 3) using a high-throughput NMR-based metabolic biomarker profiling platform developed by Nightingale Health Ltd. The measurements took place between June 2019 and April 2020 (Phase 1) and April 2020 and June 2022 (Phase 2) using eight spectrometers at Nightingale Health, based in Finland.

The biomarkers span multiple metabolic pathways, including lipoprotein lipids in 14 subclasses, fatty acids and fatty acid compositions, as well as various low-molecular weight metabolites, such as amino acids, ketone bodies, and glycolysis metabolites quantified in molar concentration units.

Previously available data from Phase 1 of the study has been updated as a part of the July 2023 release due to updates in spectrometer recalibration (further information can be found inResource 130). Currently available data is not final and may be updated due to recalibration and normalisation procedures before the project completes.