| Title: | Serum cardiometabolic biomarkers in relation to all-cause and cause-specific mortality |
| Lead Institution: | Nanjing Medical University |
| Principal investigator: | Dr Dong Hang |
Application 52217
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About
Despite substantial epidemiologic evidence supports the association between cardiometabolic biomarkers and risk of cardiovascular, metabolic disease and cancer, how these biomarkers may influence all-cause and cause-specific mortality remain to be established. Previous studies were limited by the relatively small sample size, inclusion of men or women only, short duration of follow up, examination of CVD or cancer mortality only, or inadequate control for confounding. Therefore, a systematic investigation of cardiometabolic biomarkers with mortality in a large-scale cohort is needed to better understand the role of metabolic disturbances in death risk. We will utilize data from UK biobank to prospectively investigate associations of 14 serum biomarkers, including lipid profiles (i.e., Cholesterol, Direct Low Density Lipoprotein, HDL-Cholesterol, Triglyceride, Apolipoprotein A, and Lipoprotein (a)), inflammatory marker (C-reactive Protein), IGF1, HbA1c, glucose, and sex hormones (i.e., testosterone, oestradiol, sex hormone binding globulin), with the risk of all-cause and cause-specific mortality (i.e., death from CVD, cancer, and other causes).2 Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3736 | 52217 | Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank | 6 Aug 2021 |
| 3735 | 52217 | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank | 6 Aug 2021 |
5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11631 | Development and validation of a blood biomarker score for predicting mortality risk in the general population | Jing Yang (+8) | 2023 | Journal of Translational Medicine |
| 3737 | Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank | Xikang Fan (+9) | 2021 | European Journal of Epidemiology |
| 7934 | Serum Calcium Concentrations and Risk of All-Cause and Cause-Specific Mortality: Results From 2 Prospective Cohorts | Mingjia Yang (+15) | 2023 | The Journal of Clinical Endocrinology & Metabolism |
| 8966 | Serum apolipoproteins and mortality risk: evidence from observational and Mendelian randomization analyses | Jiacong Li (+7) | 2024 | American Journal of Clinical Nutrition |
| 3736 | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank | Xikang Fan (+8) | 2020 | The Journal of Clinical Endocrinology & Metabolism |
2 Categories
| Category ID | Description | Items |
|---|---|---|
| 18518 | Blood biochemistry processing | 180 |
| 1019 | Linked health outcomes | 75 |
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