| Title: | Serum Calcium Concentrations and Risk of All-Cause and Cause-Specific Mortality: Results From 2 Prospective Cohorts |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 18 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36806939/ |
| DOI: | https://doi.org/10.1210/clinem/dgad078 |
| Citations: | 4 (4 in last 2 years) as of 8 Aug 2024 |
Publication 7934
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Abstract
CONTEXT: Calcium plays a critical role in various physiological activities. However, the association between circulating calcium concentrations and mortality in a general healthy population remains undetermined.</p>
OBJECTIVE: To examine the association of serum calcium concentrations with all-cause and cause-specific mortality.</p>
METHODS: Leveraging data from the UK Biobank (n = 361 662) and the US National Health and Nutrition Examination Survey (NHANES, n = 36 985), we prospectively examined the association of serum calcium concentrations with all-cause and cause-specific mortality using Cox proportional hazard and restricted cubic spline models.</p>
RESULTS: During a median follow-up of 12.0 years, UK Biobank documented 18 327 deaths, including 3119 (17.0%) from cardiovascular disease (CVD) and 9599 (52.4%) from cancer. We found a U-shaped relationship of albumin-adjusted calcium concentrations with all-cause and CVD mortality. Compared with participants with moderate calcium levels (the third quintile, Q3), those with low and high levels had an increased risk of all-cause (hazard ratio [HR] 1.02 for Q1 vs Q3; 1.10 for Q5 vs Q3) and CVD mortality (HR 1.11 for Q1 vs Q3; 1.25 for Q5 vs Q3). In contrast, there was a linear positive relationship with cancer mortality (HR 1.09 for Q5 vs Q1). Similar results for all-cause, CVD, and cancer mortality were observed in US NHANES.</p>
CONCLUSION: Our findings provide novel insights into the association between serum calcium concentrations and mortality in the general healthy population.</p>
16 Authors
- Mingjia Yang
- Junyan Miao
- Lingbin Du
- Jiayu Wang
- Jing Yang
- Jiayi Lu
- Xikang Fan
- Changzhi Huang
- Zan Fu
- Zekuan Xu
- Mingyang Song
- Hongxia Ma
- Guangfu Jin
- Zhibin Hu
- Dong Hang
- Hongbing Shen
1 Application
| Application ID | Title |
|---|---|
| 52217 | Serum cardiometabolic biomarkers in relation to all-cause and cause-specific mortality |
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