| Title: | Exploring the associations of lifestyle, environmental and genetic factors on metabolic diseases and cancer |
| Lead Institution: | Shanghai University of Traditional Chinese Medicine |
| Principal investigator: |
Application 221713
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About
Metabolic diseases (such as diabetes, cardiovascular diseases, and non-alcoholic fatty liver disease) and cancers significantly contribute to the global disease burden, with their occurrence and progression being the result of an interplay between genetic susceptibility and environmental risk factors. This project aims to determine the individual and combined impacts of genetic, environmental, and metabolic factors on the onset and progression of metabolic diseases and cancers. The UK Biobank represents an invaluable resource for conducting large-scale epidemiological studies. Utilizing the UK Biobank's extensive data, we plan to employ a combination of cohort studies, genome-wide association studies (GWAS), and Mendelian randomization to investigate the relationships between nutritional, lifestyle, metabolic factors, and the onset and progression of metabolic diseases and cancers over a three-year period. Identifying risk factors for metabolic diseases and cancer can guide the development of public health policies aimed at reducing the incidence of these diseases and alleviating their significant socio-economic burden. This project will enable individuals to adopt healthier lifestyles and dietary patterns, preventing disease onset and enhancing quality of life. Furthermore, investigating the interaction of genetic and environmental factors is expected to facilitate further biological research and shed light on the biological basis of disease occurrence and progression. Through this comprehensive approach, we hope to uncover the complex interrelationships between genetic susceptibility and environmental exposures, providing new insights for effective prevention and intervention strategies, and ultimately alleviating the burden of metabolic diseases and cancers globally.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17883 | Association between triglyceride-glucose-related indices and liver-related events in patients with type 2 diabetes | Yanan Mi (+6) | 2026 | Frontiers in Endocrinology |
Enabling scientific discoveries that improve human health