| Title: | Association between triglyceride-glucose-related indices and liver-related events in patients with type 2 diabetes |
| Journal: | Frontiers in Endocrinology |
| Published: | 22 Apr 2026 |
| DOI: | https://doi.org/10.3389/fendo.2026.1760656 |
Publication 17883
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Accumulating evidence has linked the triglyceride-glucose (TyG) index and its derived measures to a broad range of diabetic complications. However, the nature of the association between these indices and subsequent liver morbidity in type 2 diabetes (T2D) patients warrants further investigation. The present analysis assessed the prospective associations between four TyG-based parameters and the incidence of liver-related events (LRE) among people with T2D. This prospective cohort study included 18,105 participants with T2D from the UK Biobank. Four TyG-related indices were assessed, including TyG, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), and TyG-waist-to-height ratio (TyG-WHtR). Cox proportional hazards models and restricted cubic spline (RCS) were used to evaluate the associations between TyG-related indices and incident LRE risk. During a median follow-up of 13.4 years, 507 T2D patients developed LRE. Compared to patients in the lowest quartile, those in the highest quartiles of both TyG-WC (HR = 1.63, 95% CI 1.12-2.38) and TyG-WHtR (HR = 1.98, 95% CI 1.36-2.89) were associated with increased risk of LRE. Restricted cubic spline models confirmed linear relationships for both TyG-WC and TyG-WHtR with LRE risk. No significant associations of TyG and TyG-BMI with LRE risk were observed. Subgroup analyses demonstrated that the associations between TyG-WC/TyG-WHtR and LRE were more pronounced in high-risk populations, including excessive alcohol consumers and individuals with FIB-4 scores ≥1.3 (indicating higher liver fibrosis risk). For instance, the association between TyG-WHtR and LRE was stronger in individuals with FIB-4 ≥1.3 (HR = 2.59, 95% CI 1.65-4.07) compared to those with FIB-4 <1.3 (HR = 1.58, 95% CI 0.76-3.29). Among T2D patients, TyG-WC and TyG-WHtR were consistently associated with increased risk of LRE, confirming the independent clinical utility of these indices. These findings demonstrate that both indices may serve as efficient, cost-effective, and practical tools for enhancing the identification and stratification of LRE risk in clinical practice.</p>
7 Authors
- Yanan Mi
- Chenhao Ye
- Deji Song
- Wang Chao
- Ziqi Zhang
- Lei Wang
- Wei Qian
1 Application
| Application ID | Title |
|---|---|
| 221713 | Exploring the associations of lifestyle, environmental and genetic factors on metabolic diseases and cancer |
Enabling scientific discoveries that improve human health