| Title: | The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation |
| Lead Institution: | University of Edinburgh |
| Principal investigator: | Dr Michelle Luciano |
Application 10279
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About
The proposed research aims to understand why it is that poorer cognitive function and negative emotional factors are typically associated with poorer health and increased mortality. We shall use health outcome data to examine how all-cause mortality and incident cancer and cardiovascular disease (CVD)vary according to prior cognitive function and negative emotions. We shall investigate the extent to which relationships we find between cognition, emotions and these health outcomes are explained or modified by physical, biological, genetic, behavioural, and socio-demographic factors. Genetic analyses will incorporate multivariate genome-wide complex trait analysis and polygenic prediction of these relationships. Poorer cognitive function and negative emotional states and traits have been shown to increase mortality but the reasons for this are unclear. We anticipate that the proposed research will: 1) show us how mortality and morbidity from common health conditions vary according to prior cognitive abilities and emotional factors; 2) reveal potential mechanisms whereby poorer cognition and negative emotion increase risk; and 3) identify whether other characteristics can increase or reduce the risk of ill health in those with poorer cognition and negative emotions. This information could help inform intervention strategies for preventing or treating common health conditions. Using data on cognitive function and negative emotions together with data collected on health outcomes, scientists at the Centre for Cognitive Ageing and Cognitive Epidemiology will examine whether cognitive performance and emotional states predict risk of all-cause mortality and the onset of cancer and CVD. They will investigate whether other characteristics, such as lifestyle, socio-demographic, physical, behavioural or biological factors, help to explain any links between cognitive function and emotions and these health outcomes. They will estimate degree of genetic sharing between: 1) cognitive function/emotions and these characteristics, and 2) cognitive function/emotions and health outcomes. The full cohort14 Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 2837 | 10279 | Assessment of Relative Utility of Underlying vs Contributory Causes of Death | 20 Nov 2020 |
| 3148 | 10279 | Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism | 26 Feb 2021 |
| 2836 | 10279 | Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank | 20 Nov 2020 |
| 2838 | 10279 | Comparison of risk factor associations in UK Biobank against representative, gen pop based studies with conventional response rates: prospective cohort study and individual participant meta-analysis | 20 Nov 2020 |
| 2772 | 10279 | GWAS on family history of Alzheimer's disease | 3 Nov 2020 |
| 1522 | 10279 | Genetic prediction of male pattern baldness | 2 Aug 2018 |
| 2771 | 10279 | Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function | 3 Nov 2020 |
| 760 | 10279 | Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112151) | 17 Oct 2017 |
| 762 | 10279 | Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions | 17 Oct 2017 |
| 796 | 10279 | Psychological distress, neuroticism, and cause-specific mortality: early prospective idence from UK Biobank | 19 Oct 2017 |
| 2786 | 10279 | Psychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies | 4 Nov 2020 |
| 3744 | 10279 | Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study based on a community sample | 12 Aug 2021 |
| 3184 | 10279 | The influence of X chromosome variants on trait neuroticism | 9 Mar 2021 |
| 1850 | 10279 | When Is Higher Neuroticism Protective Against Death? Findings From UK Biobank | 6 Dec 2019 |
14 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2838 | Assessment of Relative Utility of Underlying vs Contributory Causes of Death | Batty et al | 2019 | JAMA Network Open (2019) |
| 3144 | Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism | Luciano et al | 2018 | Nature Genetics (2018) |
| 2837 | Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank | Gale et al | 2018 | Scientific Reports (2018) |
| 2839 | Comparison of risk factor associations in UK Biobank against representative, gen pop based studies with conventional response rates: prospective cohort study and individual participant meta-analysis | Batty et al | 2020 | BMJ (2020) |
| 2773 | GWAS on family history of Alzheimer's disease | Marioni et al | 2018 | Translational Psychiatry (2018) |
| 1523 | Genetic prediction of male pattern baldness | Hagenaars, S.P. et al. | 2017 | PLoS Genet. 2017. |
| 2772 | Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function | Hagenaars et al | 2018 | PLOS One (2018) |
| 761 | Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112151) | Davie et al | 2016 | Molecular Psychiatry 2016 |
| 763 | Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions | Hill et al | 2016 | Transl Psychiatry 2016 |
| 797 | Psychological distress, neuroticism, and cause-specific mortality: early prospective idence from UK Biobank | Batty et al | 2016 | J Epidemiol Community Health 2016 |
| 2787 | Psychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies | Batty et al | 2018 | Translational Psychiatry 2018 |
| 3745 | Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study based on a community sample | Batty et al., | 2014 | Brain, Behavior, and Immunity (2020) |
| 3185 | The influence of X chromosome variants on trait neuroticism | Luciano et al | 2021 | Molecular Psychiatry (2021) |
| 1851 | When Is Higher Neuroticism Protective Against Death? Findings From UK Biobank | Gale et al | 2017 | Psychological Science 2017 |