| Application: | 15168, Vitamin D status and Musculoskeletal Health in the UK Biobank: Relationships with Genetic Polymorphisms, Diet, Gender and Lifestyle Factors in South Asian and Caucasian Populations |
| Title: | Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort |
| Size: | 33319 B |
| Archived: | 19 Jan 2022 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 4289
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Notes
This return contains the SPSS code used for analyses reported in the following publication:Vearing, R.M. et al. Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort. Nutrients. 2021 Nov 16;13(11):4104. doi: 10.3390/nu13114104.
Vitamin D is a unique vitamin, as it can be sourced from both sunlight and also through food. Vitamin D is essential for absorbing calcium, and therefore has a direct link to bone health. Individuals living in the UK, especially those with darker skin types, are at risk of vitamin D deficiency, especially during the winter months when it is not possible to source vitamin D from the sun. This study aimed to measure levels of vitamin D deficiency (<25nmol/L) in the UK African-Caribbean population, through analysing the UK Biobank data set, which contains data on the health and well-being of over 502,000 individuals.
Of the 4046 African Caribbean individuals from the UK Biobank, 37% were vitamin D deficient (<25nmol/L) and over 40% were insufficient (25-50nmol/L). In addition, over 95% of the population has an insufficient intake of vitamin D (<10µg/day). These high levels of deficiency and insufficiency are concerning, due to the association of poor vitamin D status with poor bone health. In addition, we also found that not consuming oily fish, such as salmon and tuna, and not taking vitamin D supplements were associated with increased likelihood of having vitamin D deficiency. From our findings, we recommend further public health messaging, especially for ethnic minority groups, to promote vitamin D supplementation and intake of food naturally rich in vitamin D (e.g. oily fish, eggs), or fortified with vitamin D (e.g. breakfast cereals).
Application 15168
Vitamin D status and Musculoskeletal Health in the UK Biobank: Relationships with Genetic Polymorphisms, Diet, Gender and Lifestyle Factors in South Asian and Caucasian Populations
We will ask the following questions: How much do people?s genes affect how much vitamin D people have, and which genes are the most important influencers of vitamin D? Also, which is more important in determining vitamin D levels, a person?s genes or other factors (e.g. diet, lifestyle, gender, ethnicity)? Adequate vitamin D levels are required for healthy bones, but it is unclear to what degree vitamin D status, diet, gender, lifestyle, ethnicity and genes affect how strong people?s bones are, and how likely they are to get osteoporosis (weak bones) and/or a bone fracture. This study meets the purpose of the UK Biobank as Vitamin D deficiency and fractures are very common, are very debilitating to the person and are costly to the NHS. It has been estimated that eradication of vitamin D deficiency in Western Europe would save society 10,000 million Euros per year1. Hip fracture treatment currently costs the UK £1.9 billion2, even without the very high associated cost of after-care. Therefore, it is in the UK public interest that the above questions are answered, in order that vitamin D deficiency, osteoporosis and associated bone fractures can be prevented. Most scientific research attempting to answer these questions has focussed on White Caucasian women, and there is a lack of data in other ethnic groups, such as South Asian men and women, as well as a lack of data in White Caucasian men. Therefore, in our study we will focus mainly on these understudied groups. We will use mathematical methods to look for patterns in the UK Biobank data to answer the above questions, This research will use data already in the UK Biobank database and so we will not need to access stored biological samples. Subset- All subjects of South Asian ethnicity (Indian, Pakistani, Bangladeshi)and White ethnicity (British/Irish and other White ethnicity).
| Lead investigator: | Professor Susan Lanham-New |
| Lead institution: | University of Surrey |
3 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3905 | 15168 | Very high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: analysis of the UK Biobank Cohort | 30 Sep 2021 |
| 3907 | 15168 | Vitamin D concentration, body mass index, ethnicity and SARS-CoV-2/COVID-19: initial analysis of the first- reported UK Biobank Cohort positive cases (n 1474) compared with negative controls (n 4643) | 30 Sep 2021 |
| 2865 | 15168 | Vitamin D supplement use and associated demographic, dietary and lifestyle factors in 8024 South Asians aged 40-69 years: analysis of the UK Biobank cohort | 24 Nov 2020 |
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