| Application: | 15168, Vitamin D status and Musculoskeletal Health in the UK Biobank: Relationships with Genetic Polymorphisms, Diet, Gender and Lifestyle Factors in South Asian and Caucasian Populations |
| Title: | Vitamin D supplement use and associated demographic, dietary and lifestyle factors in 8024 South Asians aged 40-69 years: analysis of the UK Biobank cohort |
| Size: | 295246 B |
| Archived: | 24 Nov 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2865
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Notes
Vitamin D deficiency is extremely common in UK South Asians but we know very little about the use of vitamin D supplements in this group. In this work we aimed to find out which dietary and lifestyle factors predict who takes a vitamin D supplement and who does not. We used data from the South Asian UK Biobank participants first visit to the Biobank assessment centre. We used data from all 8024 South Asians (Bangladeshi, Indian and Pakistani).We found that only 23% of men and 39% of women used a vitamin D supplement. In terms of ethnic sub-group, only 22% of Bangladeshis, 32% of Indians and 25% of Pakistanis used a vitamin D supplement. Vitamin D intakes from diet were low at 1.0-3.0 micrograms per day, being highest in Bangladeshis and lowest in Indians. Mathematical modelling showed that females were twice as likely to use a vitamin D supplement than were men. We found that younger persons (40-60 years) were 25% less likely to use a vitamin D supplement than were those over 60 years old. We also found a suggestion that a lower body mass index, living in Greater London, having a higher oily fish intake and higher household income may be associated with being more likely to be a vitamin D supplement user.
Overall we concluded that vitamin D supplements were not used by most South Asians and vitamin D intakes from diet alone are unlikely to ensure good vitamin D health in this group. We now need public health strategies urgently to promote the use of vitamin D supplements in these specific UK South Asian sub-groups.
Application 15168
Vitamin D status and Musculoskeletal Health in the UK Biobank: Relationships with Genetic Polymorphisms, Diet, Gender and Lifestyle Factors in South Asian and Caucasian Populations
We will ask the following questions: How much do people?s genes affect how much vitamin D people have, and which genes are the most important influencers of vitamin D? Also, which is more important in determining vitamin D levels, a person?s genes or other factors (e.g. diet, lifestyle, gender, ethnicity)? Adequate vitamin D levels are required for healthy bones, but it is unclear to what degree vitamin D status, diet, gender, lifestyle, ethnicity and genes affect how strong people?s bones are, and how likely they are to get osteoporosis (weak bones) and/or a bone fracture. This study meets the purpose of the UK Biobank as Vitamin D deficiency and fractures are very common, are very debilitating to the person and are costly to the NHS. It has been estimated that eradication of vitamin D deficiency in Western Europe would save society 10,000 million Euros per year1. Hip fracture treatment currently costs the UK £1.9 billion2, even without the very high associated cost of after-care. Therefore, it is in the UK public interest that the above questions are answered, in order that vitamin D deficiency, osteoporosis and associated bone fractures can be prevented. Most scientific research attempting to answer these questions has focussed on White Caucasian women, and there is a lack of data in other ethnic groups, such as South Asian men and women, as well as a lack of data in White Caucasian men. Therefore, in our study we will focus mainly on these understudied groups. We will use mathematical methods to look for patterns in the UK Biobank data to answer the above questions, This research will use data already in the UK Biobank database and so we will not need to access stored biological samples. Subset- All subjects of South Asian ethnicity (Indian, Pakistani, Bangladeshi)and White ethnicity (British/Irish and other White ethnicity).
| Lead investigator: | Professor Susan Lanham-New |
| Lead institution: | University of Surrey |
3 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3905 | 15168 | Very high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: analysis of the UK Biobank Cohort | 30 Sep 2021 |
| 4289 | 15168 | Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort | 19 Jan 2022 |
| 3907 | 15168 | Vitamin D concentration, body mass index, ethnicity and SARS-CoV-2/COVID-19: initial analysis of the first- reported UK Biobank Cohort positive cases (n 1474) compared with negative controls (n 4643) | 30 Sep 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2866 | Vitamin D supplement use and associated demographic, dietary and lifestyle factors in 8024 South Asians aged 40-69 years: analysis of the UK Biobank cohort | Darling AL et al. | 2018 | Public Health Nutr |
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