| Application: | 15168, Vitamin D status and Musculoskeletal Health in the UK Biobank: Relationships with Genetic Polymorphisms, Diet, Gender and Lifestyle Factors in South Asian and Caucasian Populations |
| Title: | Very high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: analysis of the UK Biobank Cohort |
| Size: | 630969 B |
| Archived: | 30 Sep 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3905
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Notes
Little large-scale research has examined the predictors of vitamin D status in western dwelling South Asians. Therefore, we assessed vitamin D deficiency in UK South Asians (aged 40-69 years) from the UK Biobank cohort. Vitamin D status was measured using the DiaSorin Liaison XL assay, with 6433 out of 8024 South Asians having a vitamin D result. Fifty-five per cent of South Asians had severe deficiency (<25nmol/L) and 92% had insufficiency (<50 nmol/L). Of concern, 20% had very severe deficiency (<15 nmol/L). Mathematical models showed that having severe deficiency was associated with: being male; Pakistani; having a higher body mass index; being 40-59 years old; never consuming oily fish; having summer sun exposure < 5 hours per day, not using a vitamin D containing supplement, having a vitamin D measurement in winter or spring and being vegetarian. Average (median) vitamin D status was 19-20 nmol/L in Scotland, Northern England, the Midlands and Wales. Across Southern England and London it was slightly higher at 24-25 nmol/L. Our analyses suggest the need for increased awareness of vitamin D deficiency in South Asians as well as urgent public health interventions to prevent and treat vitamin D deficiency in this group.Application 15168
Vitamin D status and Musculoskeletal Health in the UK Biobank: Relationships with Genetic Polymorphisms, Diet, Gender and Lifestyle Factors in South Asian and Caucasian Populations
We will ask the following questions: How much do people?s genes affect how much vitamin D people have, and which genes are the most important influencers of vitamin D? Also, which is more important in determining vitamin D levels, a person?s genes or other factors (e.g. diet, lifestyle, gender, ethnicity)? Adequate vitamin D levels are required for healthy bones, but it is unclear to what degree vitamin D status, diet, gender, lifestyle, ethnicity and genes affect how strong people?s bones are, and how likely they are to get osteoporosis (weak bones) and/or a bone fracture. This study meets the purpose of the UK Biobank as Vitamin D deficiency and fractures are very common, are very debilitating to the person and are costly to the NHS. It has been estimated that eradication of vitamin D deficiency in Western Europe would save society 10,000 million Euros per year1. Hip fracture treatment currently costs the UK £1.9 billion2, even without the very high associated cost of after-care. Therefore, it is in the UK public interest that the above questions are answered, in order that vitamin D deficiency, osteoporosis and associated bone fractures can be prevented. Most scientific research attempting to answer these questions has focussed on White Caucasian women, and there is a lack of data in other ethnic groups, such as South Asian men and women, as well as a lack of data in White Caucasian men. Therefore, in our study we will focus mainly on these understudied groups. We will use mathematical methods to look for patterns in the UK Biobank data to answer the above questions, This research will use data already in the UK Biobank database and so we will not need to access stored biological samples. Subset- All subjects of South Asian ethnicity (Indian, Pakistani, Bangladeshi)and White ethnicity (British/Irish and other White ethnicity).
| Lead investigator: | Professor Susan Lanham-New |
| Lead institution: | University of Surrey |
3 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 4289 | 15168 | Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort | 19 Jan 2022 |
| 3907 | 15168 | Vitamin D concentration, body mass index, ethnicity and SARS-CoV-2/COVID-19: initial analysis of the first- reported UK Biobank Cohort positive cases (n 1474) compared with negative controls (n 4643) | 30 Sep 2021 |
| 2865 | 15168 | Vitamin D supplement use and associated demographic, dietary and lifestyle factors in 8024 South Asians aged 40-69 years: analysis of the UK Biobank cohort | 24 Nov 2020 |
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