| Title: | Genetics, Fatty acids and Health Outcomes in the UKBiobank |
| Lead Institution: | Fatty Acid Research Institute |
| Principal investigator: | Dr Nathan Tintle |
Application 85092
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Emerging evidence suggests that fatty acid levels are strongly associated with a wide variety of health outcomes including cardiometabolic, cognitive, eye health, joint health and all-cause mortality, among others. Fatty acid levels in the blood are determined by a mix of both genetic and nutritional (what you eat) factors. In this research we will use fatty acid level data from UkBiobank participants to determine (a) which genes are most associated with fatty acid levels in UkBiobank, (b) which health outcomes are most associated with fatty acid levels in UkBiobank and (c) how fatty acid levels may be more strongly associated with health outcomes in some people (e.g., certain genetic profiles). By confirming these associations in UKBiobank, we will gain additional insights into disease pathways for common diseases and how certain groups of individuals may benefit from nutritional intervention strategies to modify fatty acid levels.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 8270 | Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look | Aleix Sala-Vila (+3) | 2023 | Nutrients |
| 15551 | The Effect of Fatty Acid Desaturase on Cardiovascular Lipid Biomarkers Depends on Circulating ω-3 and ω-6 Polyunsaturated Fatty Acids in the UK Biobank | Carmen E. Arrington (+3) | 2025 | Nutrients |
Enabling scientific discoveries that improve human health