| Title: | Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look |
| Journal: | Nutrients |
| Published: | 23 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38068754/ |
| DOI: | https://doi.org/10.3390/nu15234896 |
| URL: | https://www.mdpi.com/2072-6643/15/23/4896/pdf?version=1700741605 |
Publication 8270
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Abstract
Dietary omega-3 fatty acids are promising nutrients in dementia. Several prospective cohort studies have examined the relationships between circulating omega-3 (an objective biomarker of dietary intake) and incident dementia, the largest to date being a report from the UK Biobank (n = 102,722). Given the recent release of new metabolomics data from baseline samples from the UK Biobank, we re-examined the association in a much larger sample (n = 267,312) and also focused on associations with total omega-3, docosahexaenoic acid (DHA), and non-DHA omega-3. Using Cox regression models, we observed that the total omega-3 status was inversely related to the risk of Alzheimer's (Q5 vs. Q1, hazard ratio [95% confidence interval] = 0.87 [0.76; 1.00]) and all-cause dementia (Q5 vs. Q1, 0.79 [0.72; 0.87]). The strongest associations were observed for total omega-3 (and non-DHA omega-3) and all-cause dementia. In prespecified strata, we found stronger associations in men, and in those aged ≥60 years at baseline (vs. those aged 50-59). Thus, in the largest study to date on this topic, we confirmed the favorable relationships between DHA and risk for dementia, and we also found evidence that non-DHA omega-3 may be beneficial. Finally, we have better defined the populations most likely to benefit from omega-3-based interventions.</p>
4 Authors
- Aleix Sala-Vila
- Nathan Tintle
- Jason Westra
- William S. Harris
1 Application
| Application ID | Title |
|---|---|
| 85092 | Genetics, Fatty acids and Health Outcomes in the UKBiobank |
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