| Application: | 29717, Advancing knowledge on physical activity and health through investigating interrelationships with lifestyle behaviours, fitness, and subclinical outcomes |
| Title: | Physical Activity and Mortality Across Levels of Adiposity: A Prospective Cohort Study From the UK Biobank |
| Size: | 253297 B |
| Archived: | 15 Sep 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3825
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Notes
ObjectiveTo examine the combined and stratified associations of physical activity and adiposity measures, modelled as body mass index (BMI), abdominal adiposity (waist circumference), and body fat percentage (BF) with all-cause mortality.
Patients and Methods
Using the UK Biobank cohort, we extracted quintiles of self-reported weekly physical activity. Categories of measured BMI, waist circumference, and BF were generated. Joint associations between physical activity-adiposity categories and mortality were examined using Cox proportional hazards models adjusted for demographic, behavioral, and clinical covariates. Physical activity-mortality associations were also examined within adiposity strata. Participants were followed from baseline (2006 to 2010) through January 31, 2018.
Results
A total of 295,917 participants (median follow-up, 8.9 years, during which 6684 deaths occurred) were included. High physical activity was associated with lower risk of premature mortality in all strata of adiposity except for those with BMI ≥35 kg/m2. Highest risk (HR, 1.54; 95% CI; 1.33 to 1.79) was observed in individuals with low physical activity and high BF as compared with the high physical activity-low BF referent. High physical activity attenuated the risk of high adiposity when using BF (HR, 1.24; 95% CI; 1.04 to 1.49), but the association was weaker with BMI (HR, 1.45; 95% CI; 1.21 to 1.73). Physical activity also attenuated the association between mortality and high waist circumference.
Conclusion
Low physical activity and adiposity were both associated with a higher risk of premature mortality, but high physical activity attenuated the increased risk with adiposity irrespective of adiposity metric, except in those with a BMI ≥35 kg/m2.
Application 29717
Advancing knowledge on physical activity and health through investigating interrelationships with lifestyle behaviours, fitness, and subclinical outcomes
The overall aim is to examine the independent and combined associations between obesity, MVPA, sedentary time and CRF with all-cause, cardio-vascular and cancer mortality. 1. To examine the independent and combined associations of MVPA, obesity, sedentary time and CRF associated with mortality? 2. To examine whether physical activity modify the association between obesity (adiposity) and mortality? 3. To examine whether sedentary time mediate the association between obesity and mortality? Obesity, moderate and vigorous intensity physical activity (MVPA), sedentary time and cardio-respiratory fitness (CRF) are all associated with a number of various health outcomes and mortality. However, the combined associations between these lifestyle variables and mortality is unknown. Further, it is unknown whether objectively measured PA may modify the association between adiposity (BMI and waist circumference) on mortality and whether objectively measured sedentary time may mediate this association. We will quantify how obesity, physical activity sedentary time and fitness are associated with mortality and the relative importance of physical inactivity, obesity, high sedentary time and low fitness on mortality. This will enable important information for intervention strategies and policy makers. Full cohort n=500,000 for most research questions, n~100,000 for the analyses involving cardio-respiratory fitness and objectively measured physical activity.
| Lead investigator: | Dr Ulf Ekelund |
| Lead institution: | Norwegian School of Sport Sciences |
1 related Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3826 | 29717 | Stair climbing and mortality: a prospective cohort study from the UK Biobank | 15 Sep 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3826 | Physical Activity and Mortality Across Levels of Adiposity: A Prospective Cohort Study From the UK Biobank | Sanchez-Lastra MA et al. | 2021 | Mayo Clin Proc |
Enabling scientific discoveries that improve human health