| Title: | Causal relationships between different exposures and major metabolic and cardiovascular diseases |
| Lead Institution: | Southern Medical University |
| Principal investigator: | Professor Huijie Zhang |
Application 68376
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About
Noncommunicable diseases including metabolic and cardiovascular diseases, including obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), metabolic syndrome, and coronary heart disease (CHD), account for more than 70% of the deaths worldwide. A variety of exposures, including dietary habits, exercise behavior, smoking, alcohol consumption, nutrient intake, beverage intake and sleep are related with the risk of these diseases. Thus, it is imperative to develop better strategies to reduce the morbidity and mortality of major metabolic and cardiovascular diseases by determining the causal associations between different exposures and major outcomes. We aim to explore the associations between different exposures and metabolic and cardiovascular disease in a large population-based cohort study. Our project will provide evidence for developing efficient strategies to reduce morbidity and mortality of metabolic and cardiovascular diseases. This project is expected to last for 36 months. The findings may deepen the understanding of associations between different exposures and metabolic and cardiovascular diseases and their related outcomes, and may provide strong evidence for the prevention and therapeutic strategy of metabolic and cardiovascular diseases, and even make a significant contribution to global public health.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9764 | Associations of Oral Contraceptive Use With Cardiovascular Disease and All-Cause Death: Evidence From the UK Biobank Cohort Study | Weijuan Dou (+16) | 2023 | Journal of the American Heart Association |
| 9641 | Associations of Serum Testosterone and Sex Hormone-binding Globulin With Incident Arrhythmias in Men From UK Biobank | Bingyan Xu (+16) | 2023 | The Journal of Clinical Endocrinology & Metabolism |
| 7929 | Insulin-Like Growth Factor 1 and Risk of Cardiovascular Disease: Results From the UK Biobank Cohort Study. | Jiayang Lin (+14) | 2023 | The Journal of Clinical Endocrinology & Metabolism |
| 9523 | Sex Hormone-Binding Globulin and Risk of Incident Dementia in Middle-Aged to Older Women: Results from the UK Biobank Cohort Study | Junlin Huang (+15) | 2023 | Neuroendocrinology |
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