| Title: | Insulin-Like Growth Factor 1 and Risk of Cardiovascular Disease: Results From the UK Biobank Cohort Study |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 22 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36810801/ |
| DOI: | https://doi.org/10.1210/clinem/dgad105 |
| Citations: | 6 (6 in last 2 years) as of 8 Aug 2024 |
Publication 7929
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
CONTEXT: Relationships between insulin-like growth factor 1 (IGF-1) levels and cardiovascular disease (CVD) in the general population remain unclear.</p>
OBJECTIVE: This study aims to investigate the association of circulating IGF-1 concentrations with CVD from a population-based cohort study.</p>
METHODS: A total of 394 082 participants without CVD and cancer at baseline from UK Biobank were included with measurements of serum IGF-1 at baseline. Main outcomes were incidence of CVD, including CVD mortality, coronary heart disease (CHD), myocardial infarction (MI), heart failure (HF), and stroke.</p>
RESULTS: Over a median 11.6 years of follow-up, UK Biobank documented 35 803 incident CVD cases, including 4231 from CVD-related death, 27 051 from CHD, 10 014 from MI, 7661 from HF, and 6802 from stroke. Dose-response analysis showed a U-shaped relationship between IGF-1 levels and cardiovascular events. Compared with the third quintile of IGF-1, the lowest category of IGF-1 was associated with increased risk of CVD (hazard ratio 1.128; 95% CI, 1.093 to 1.164), CVD mortality (1.294; 1.181 to 1.418), CHD (1.118; 1.078 to 1.159), MI (1.071; 1.008 to 1.139), HF (1.185; 1.107 to 1.268), and stroke (1.149, 1.070 to 1.235); also, the highest category was associated with increased risk of CVD (1.056; 1.020 to 1.094), CVD mortality (1.111; 1.000 to 1.236), CHD (1.070; 1.028 to 1.114), MI (1.111; 1.041 to 1.187) and HF (1.098; 1.015 to 1.188) after multivariable adjustment.</p>
CONCLUSION: This study indicates that both low and high levels of circulating IGF-1 are associated with increased risk of CVD in general population. These results highlight the importance of monitoring IGF-1 status on cardiovascular health.</p>
15 Authors
- Jiayang Lin
- Linjie Yang
- Junlin Huang
- Yating Liu
- Xuzhen Lei
- Ruxin Chen
- Bingyan Xu
- Chensihan Huang
- Weijuan Dou
- Xueyun Wei
- Deying Liu
- Peizhen Zhang
- Yan Huang
- Zhimin Ma
- Huijie Zhang
1 Application
| Application ID | Title |
|---|---|
| 68376 | Causal relationships between different exposures and major metabolic and cardiovascular diseases |
Enabling scientific discoveries that improve human health