| Title: | Associations of Serum Testosterone and Sex Hormone-binding Globulin With Incident Arrhythmias in Men From UK Biobank |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 4 Sep 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37665960/ |
| DOI: | https://doi.org/10.1210/clinem/dgad526 |
Publication 9641
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
CONTEXT: Sex hormones have been identified as cardiovascular risk factors, whereas the relationship between sex hormones and the risk of arrhythmias in men has not yet been well studied in the prospective cohort study.</p>
OBJECTIVE: To analyze associations of serum testosterone and SHBG concentrations and calculate free testosterone (cFT) with arrhythmias in men.</p>
METHODS: Sex hormones were measured at baseline from UK Biobank. Main outcomes were incidence of atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia (BA).</p>
RESULTS: Of 173 498 men (aged 37-73 years, followed for 11 years), 11 368 had incident AF, 1646 had incident VA, and 4788 had incident BA. Compared with the third quartiles, the lowest category of serum testosterone was associated with increased risks of AF (hazard ratio [HR], 1.06; 95% CI, 1.00-1.12) and BA (HR, 1.11; 95% CI, 1.02-1.20) after multivariable adjustment, but no VA. Likewise, similar associations were found between cFT values and AF and BA events. Furthermore, higher levels of cFT were associated with increased risks of AF (HR, 1.07; 95% CI, 1.02-1.13) and VA (HR, 1.18; 95% CI, 1.01-1.37). Higher SHBG concentrations were associated with increased risks of AF (HR, 1.44; 95% CI, 1.34-1.54), VA (HR, 1.27; 95% CI, 1.07-1.52), and BA (HR, 1.17; 95% CI ,1.05-1.29).</p>
CONCLUSIONS: Lower levels of testosterone and cFT were associated with increased risk of AF and BA. Higher cFT levels were associated with increased risk of AF and VA. Higher SHBG levels were associated with increased risk of AF, VA, and BA.</p>
17 Authors
- Bingyan Xu
- Wei Mo
- Xiangliang Tan
- Peizhen Zhang
- Junlin Huang
- Chensihan Huang
- Dan Guo
- Xueyun Wei
- Yating Liu
- Xuzhen Lei
- Weijuan Dou
- Jiayang Lin
- Deying Liu
- Linjie Yang
- Yan Huang
- Huijie Zhang
- Yunfei Liao
1 Application
| Application ID | Title |
|---|---|
| 68376 | Causal relationships between different exposures and major metabolic and cardiovascular diseases |
Enabling scientific discoveries that improve human health