| Title: | Dietary index for gut microbiota, genetic risk, and incidence of breast cancer: a prospective study |
| Journal: | Breast Cancer Research |
| Published: | 1 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41068969/ |
| DOI: | https://doi.org/10.1186/s13058-025-02093-8 |
| URL: | https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/s13058-025-02093-8 |
Publication 16607
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Abstract
BackgroundAs a novel index designed to quantify the dietary impact on gut microbiota, the Dietary Index for Gut Microbiota (DI-GM) remains unexplored in relation to breast cancer risk. This study aimed to explore the association between DI-GM and breast cancer risk and evaluate its combined effect with genetic risk.MethodsA total of 96,195 participants from UK Biobank cohort were included in the study. DI-GM was constructed from 14 dietary components known to influence gut microbial diversity and was divided into three groups. A polygenic risk score (PRS) for breast cancer was constructed using 168 single-nucleotide polymorphisms to assess genetic risk. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsDuring a median follow-up period of 12.86 years, 3,128 individuals developed breast cancer. In the multivariable-adjusted model, each point increase in DI-GM score was associated with a 5% reduction in breast cancer risk (95% CI: 0.92-0.99). Compared with those in low DI-GM, participants with high DI-GM were associated with a decreased breast cancer risk (HR: 0.89; 95% CI: 0.81-0.97). Joint analysis revealed that participants with high DI-GM and low PRS had a 35% lower risk of breast cancer compared with those in low DI-GM and high PRS (95% CI: 0.29-0.42). Notably, additive interactions were observed between DI-GM and PRS. Compared with individuals with low DI-GM, high DI-GM was significantly associated with a reduced breast cancer risk in individuals with low PRS (HR: 0.79; 95% CI: 0.65-0.97).ConclusionHigher DI-GM was associated with a decreased risk of breast cancer, highlighting the importance of considering a gut microbiota-friendly diet in breast cancer precision prevention.</p>
16 Keywords
- Adult
- Aged
- Breast Neoplasms
- Diet
- Female
- Follow-Up Studies
- Gastrointestinal Microbiome
- Genetic Predisposition to Disease
- Humans
- Incidence
- Middle Aged
- Polymorphism, Single Nucleotide
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- United Kingdom
14 Authors
- Xi-Yang Chen
- Ying Wang
- Dong-Run Li
- Bang-Quan Liu
- Qian Fang
- Yu-Han Chen
- Jia-Xin Liu
- Chao Ni
- Wen-Rui Zheng
- Jia-Cheng Liu
- Xue Qin
- Shan-Yan Gao
- Ting-Ting Gong
- Qi-Jun Wu
1 Application
| Application ID | Title |
|---|---|
| 211772 | Understanding the role of modifiable and genetic factors with sarcopenia in UK biobank: a longitudinal analysis |
Enabling scientific discoveries that improve human health