| Title: | Understanding the role of modifiable and genetic factors with sarcopenia in UK biobank: a longitudinal analysis |
| Lead Institution: | Shengjing Hospital of China Medical University |
| Principal investigator: |
Application 211772
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Scientific rationale: Sarcopenia is a common skeletal muscle disorder among older adults, with an increased risk of various adverse conditions, including impaired mobility, increased risk of morbidity, hospitalization, and mortality. It is still a challenge to utilize the information of environmental, metabolic, diet, lifestyle habits, and genetic data to predict the risk of the sarcopenia. Aim: In this study, we aim to: (1) estimate the associations of environmental, metabolic, diet, lifestyle habits, and genetic, the interactions of these risk factors, as well as their impact on the risk of sarcopenia. (2) investigate the causal association between environmental, metabolic, diet, lifestyle habits, and genetic with sarcopenia using Mendelian randomization instrumental variable analysis. Project duration: The project period will be maximally 36 months. Public health impact: Through this study, we will be able to identify robust, sensitive, and accessible risk factors of sarcopenia, which will help researchers comprehensively understand the development of sarcopenia, and will be helpful in the precise and individual prevention of sarcopenia.11 Publications
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