| Title: | Plasma leptin, resistin, tumor necrosis factor-alpha, and interleukin-6 with risk of dementia: A prospective population study |
| Journal: | Journal of Alzheimer's Disease |
| Published: | 2 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40598949/ |
| DOI: | https://doi.org/10.1177/13872877251352480 |
Publication 16520
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundAdipokines secreted from adipose tissue may contribute to dementia pathogenesis.Objective: Our study investigated the associations between plasma levels of leptin, resistin, TNF-α, and IL-6 and the risk of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD).MethodsPlasma protein levels were measured using the Olink Proximity Extension Assay, and dementia was ascertained from hospital admissions and death registries in the UK Biobank. Multivariable Cox proportional hazards models with stepwise covariate adjustments were used to assess associations. Subgroup analyses were conducted to examine whether the associations differed by sociodemographic characteristics, lifestyle factors, and major diseases.ResultsAmong 32,002 participants, 793 developed all-cause dementia, including 260 with AD and 96 with VaD. Plasma levels of resistin and IL-6 were positively associated with risks of all-cause dementia, with hazard ratios (95% confidence intervals) of 1.10 (1.03, 1.18) and 1.10 (1.04, 1.17), respectively. Leptin (0.98; 0.86, 1.12) and TNF-α levels (1.06; 0.98, 1.13) were not significantly associated with all-cause dementia. Resistin (1.28; 1.08, 1.53) and TNF-α levels (1.21; 1.04, 1.40) were associated with VaD risk. There was a lack of evidence for the associations between four adipokines and AD. Subgroup analyses showed stronger associations between resistin and all-cause dementia in those with high body mass index, diabetes, or stroke.ConclusionsPlasma levels of resistin and IL-6 were positively associated with risks of all-cause dementia, with resistin and TNF-α strongly linked to VaD. These findings support a potential role of adipokines in dementia pathogenesis, particularly for VaD.</p>
12 Authors
- Peiqi Zhang
- Nianwei Wu
- Qingping Xue
- Jingyi Li
- Qingqing Ouyang
- Xinyue Yu
- Yunhaonan Yang
- Yidan Dong
- Fan Li
- Tianlei Wang
- Shuo Li
- Xiong-Fei Pan
1 Application
| Application ID | Title |
|---|---|
| 103011 | Understanding the Impact of Reproductive Health and Other Related Factors on Multimorbidity in the UK Biobank |
Enabling scientific discoveries that improve human health