| Title: | Understanding the Impact of Reproductive Health and Other Related Factors on Multimorbidity in the UK Biobank |
| Lead Institution: | Sichuan University |
| Principal investigator: |
Application 103011
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Multimorbidity, defined as the coexistence of two or more chronic conditions in an individual, is a growing global public health concern. It is associated with compromised quality of life, increased healthcare utilization and costs, and increased mortality risk. Reproductive health issues are associated with higher risks of multiple non-communicable diseases. Traditional risk factors, such as socioeconomic status, environmental, lifestyle, reproductive, dietary, and mental factors, are reported to play a significant role in the development of multimorbidity. However, the underlying mechanisms through which reproductive health issues may contribute to the development and progression of multimorbidity are still unknown. In addition, the modifying effects of traditional factors for the association between reproductive health and multimorbidity, are not well understood. The proposed research project aims to address this knowledge gap by investigating the impact of reproductive health on multimorbidity using a large study population from the UK Biobank. In addition, it will address the interaction of traditional factors with reproductive factors for risk of multimorbidity, and uncover potential pathways using large-scale omics data. Overall, this research project has the potential to make a significant contribution to our understanding of the complex relationship between reproductive health and multimorbidity, and to inform the development of strategies aimed at improving population health. The proposed program will last for three years but it might be prolonged due to advances in methodology and novel findings which may require external validations.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 15415 | Association between multiple complications of pregnancy and risk of cardiovascular disease in a large cohort | Jingyi Li (+12) | 2025 | International Journal of Cardiology Cardiovascular Risk and Prevention |
| 15473 | Associations of Hysterectomy, Oophorectomy, and Hormone Replacement Therapy With the Risk of Type 2 Diabetes Mellitus in Postmenopausal Women | Qingqing Ouyang (+14) | 2025 | Clinical Endocrinology |
| 16520 | Plasma leptin, resistin, tumor necrosis factor-alpha, and interleukin-6 with risk of dementia: A prospective population study | Peiqi Zhang (+11) | 2025 | Journal of Alzheimer's Disease |
Enabling scientific discoveries that improve human health