| Title: | Male sex hormone concentrations, puberty timing, baldness patterns, and risk of cardiovascular disease |
| Journal: | Hormones |
| Published: | 29 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40301276/ |
| DOI: | https://doi.org/10.1007/s42000-025-00655-1 |
Publication 15722
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Abstract
PurposeStudies exploring the relationship between male-specific factors and risks of cardiovascular disease (CVD) are limited and inconsistent. We aimed to examine the association of male hormone levels and sexual factors (e.g., onset of puberty and baldness pattern) with CVD events.MethodsThis study included 154,970 men from the UK Biobank for prospective analyses. Cox proportional hazards regression was performed, with outcomes of CVD, coronary heart disease (CHD), stroke, and heart failure (HF), and adjusted for sociodemographics, lifestyle, and medical factors. Restricted cubic spline models assessed nonlinear associations between sex hormone levels and CVD risks.ResultsOver a median follow-up of 13.0 years, 20,216 men (13.0%) experienced a CVD event. Men in the highest quintile of total testosterone had increased stroke risk (HR 1.13, 95% CI: 1.04-1.23). A J-shaped relationship was found between sex hormone-binding globulin (SHBG) levels and CVD risk, with the highest risk in Q5 (1.08, 1.03-1.13). A U-shaped association was noted for free testosterone (FT), where Q3 had lower CVD risk (0.94, 0.90-0.98). Earlier onset of facial hair or voice breaking (< 13 years) correlated with higher CVD risks (HR 1.10, 95% CI: 1.04-1.16 and HR 1.14, 95% CI: 1.06-1.22, respectively). Vertex baldness was linked to increased CVD risk (1.05, 1.01-1.09) and CHD risk (1.06, 1.02-1.11).ConclusionsElevated SHBG levels, earlier puberty onset, and vertex baldness were associated with increased CVD risks in men, highlighting the need for targeted prevention strategies.</p>
7 Authors
- Meiling Li
- Xiaoyi Wang
- Qi Wang
- Chunying Fu
- Nipun Shrestha
- Salim S. Virani
- Dongshan Zhu
1 Application
| Application ID | Title |
|---|---|
| 227947 | The impact of life course multimorbidity and their trajectories on later-life health outcomes and the roles of genetic, socioeconomic and lifestyle factors |
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