| Title: | The impact of life course multimorbidity and their trajectories on later-life health outcomes and the roles of genetic, socioeconomic and lifestyle factors |
| Lead Institution: | Shandong University |
| Principal investigator: |
Application 227947
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About
Human health is a dynamic continuum, evolving with each life stage, where early experiences of illness can profoundly influence well-being in later years. The paths these comorbidities take can differ greatly among individuals. Understanding how these variations influence health outcomes in later life, and the potential moderating effects of socioeconomic status and lifestyle, is crucial for developing targeted interventions. We aim to understand how having multiple chronic conditions simultaneously or sequentially throughout one's life affects later-life health outcomes, including chronic disease, decline in physical and cognitive function, quality of life, and mortality. We also aim to explore whether and how factors like income, education, occupation (as proxies for SES), and lifestyle choices (e.g., diet, physical activity, smoking, alcohol consumption) influence the health impacts of multimorbidity on later-life health outcomes. The findings of this project may help us to understand how multiple chronic conditions evolve together over an individual's lifetime, contributing to the natural history of diseases. It also can identify specific patterns of multimorbidity and their predictors, including how socioeconomic status and lifestyle factors influence these trajectories, providing valuable data for tailoring interventions. The insights into how socioeconomic factors and lifestyle choices modulate the effects of multimorbidity can help in designing interventions that address health disparities, promoting equity in health outcomes.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 15722 | Male sex hormone concentrations, puberty timing, baldness patterns, and risk of cardiovascular disease | Meiling Li (+6) | 2025 | Hormones |
| 15513 | The fall-dementia connection: Synergistic effects of falls with genetic and health risk factors | Zhongxuan Wang (+6) | 2025 | Journal of Alzheimer's Disease |
| 16385 | Years since menopause and its metabolomic signature with biological aging in women at midlife: a population-based study | Bo Xie (+5) | 2025 | npj Aging |
Enabling scientific discoveries that improve human health