| Title: | Associations of Alcohol Consumption and Genetic Predisposition to Hepatic Steatosis With Liver-Related Events: Results From Large Population-Based Cohort Studies |
| Journal: | Gastroenterology |
| Published: | 14 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40379147/ |
| DOI: | https://doi.org/10.1053/j.gastro.2025.04.021 |
Publication 15373
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Abstract
BACKGROUND & AIMS: The new classification for steatotic liver disease identifies 3 phenotypes based on alcohol consumption. The aim of this study was to evaluate the associations between alcohol intake and liver-related events (LREs) across different drinking categories and whether genetic predisposition influences these associations.</p>
METHODS: Data from 301,673 UK Biobank participants were analyzed. Alcohol consumption was self-reported and categorized by weekly intake as mild (< 140 g for females and < 210 g for males), moderate (140-350 g for females and 210-420 g for males), and heavy (> 350 g in females and > 420 g for males). A polygenic risk score based on 5 well-known single nucleotide polymorphisms associated with hepatic steatosis was calculated. Hazard ratios (HRs) and 95% CIs were calculated using Cox proportional hazard models. The analysis was validated in 47,252 participants from China Kadoorie Biobank.</p>
RESULTS: During a median follow-up of 12.8 years, 1742 incident cases of LREs were documented. The multivariable-adjusted HRs per SD increment in alcohol intake for LREs were 0.95 (95% CI, 0.89-1.02) among mild drinkers, 1.23 (95% CI, 1.10-1.37) among moderate drinkers, and 1.18 (95% CI, 1.14-1.22) among heavy drinkers. The associations appeared stronger in those with high genetic risk. Compared with adults with low genetic risk and mild alcohol consumption, those with high genetic risk and heavy alcohol consumption had higher risks of LREs (HR, 6.50; 95% CI, 5.26-8.04; P for interaction < .001). Similar findings were observed in China Kadoorie Biobank.</p>
CONCLUSIONS: Associations between alcohol intake and LREs vary across different drinking categories. Individuals with a higher genetic risk for steatotic liver disease appear more susceptible to alcohol.</p>
18 Keywords
- Adult
- Aged
- Alcohol Drinking
- Fatty Liver
- Fatty Liver, Alcoholic
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- Male
- Middle Aged
- Multifactorial Inheritance
- Non-alcoholic Fatty Liver Disease
- Phenotype
- Polymorphism, Single Nucleotide
- Risk Assessment
- Risk Factors
- United Kingdom
13 Authors
- Hongliang Xue
- Liqing Wang
- Dianjianyi Sun
- Yuankai Wu
- Canqing Yu
- Yating Huang
- Sun On Chan
- Wenhua Ling
- Jun Lv
- Liming Li
- Xu Chen
- Yuanjie Pang
- Chao Yu
2 Applications
| Application ID | Title |
|---|---|
| 76670 | Nutritional and lifestyle influences on the risk and outcome of different metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes |
| 420999 | Dissecting the environmental, genetic and clinical determinants and their interactions on chronic diseases and its underlying mechanisms |
Enabling scientific discoveries that improve human health