| Title: | Dissecting the environmental, genetic and clinical determinants and their interactions on chronic diseases and its underlying mechanisms |
| Lead Institution: | Guangzhou Medical University |
| Principal investigator: |
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About
Chronic diseases mainly include malignant tumors, cardiovascular and cerebrovascular diseases, heart diseases, hypertension, diabetes, mental illnesses and a series of non-infectious diseases which cannot be recovered by the patients themselves. With the development of the social economy and changes in people's lifestyle, the global disease spectrum has undergone tremendous changes. The prevalence of chronic diseases which closely related to environmental factors and unhealthy lifestyles has become increasingly serious, posing severe challenges for prevention and treatment. Clinical determinants are factors that can influence the onset, progression, and management of chronic conditions over a long period of time. Some of the key clinical determinants include genetics, age, gender, medication use, treatment choice, and comorbidities. If only looking for the factors affecting the onset of chronic diseases from a single factor, it cannot reflect their true role in the progression of the disease. Therefore, the aim of this study was to evaluate the integrative impact of collective and individual factors, dissecting the environmental, genetic and clinical determinants on chronic diseases and dissect the underlying mechanisms in order to provide evidence for public health intervention and policy making. The UK Biobank with a natural population could provide comprehensive population chronic diseases assessment studies from the perspective of environmental exposure, genetic factors and clinical determinants and their interactions. We expect to deeply analyze the impact of collective and individual factors on chronic diseases and evaluate the interaction of environmental, genetic, and clinical decision-making factors on the progress of chronic diseases in the next 3 years. This complicated project includes several independent analyses and requires close collaborations among several research groups. Our study may propose targeted, scientifically practical chronic disease prevention and health protection strategies and intervention plans, thereby greatly improving the effectiveness of health intervention programs.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16047 | Association between questionnaire- and accelerometer-measured physical activity and incidence of cardiovascular disease in subjects with metabolic dysfunction-associated steatotic liver disease | Yingxin Liao (+9) | 2025 | American Journal of Preventive Cardiology |
| 15373 | Associations of Alcohol Consumption and Genetic Predisposition to Hepatic Steatosis With Liver-Related Events: Results From Large Population-Based Cohort Studies | Hongliang Xue (+12) | 2025 | Gastroenterology |
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