: Return 2838

Notes

Large, well-designed prospective cohort studies are very useful for identifying risk factors for chronic disease. UK Biobank is one such study, made up of about 500,000 people who have been extensively characterized for a wide range of phenotypes. However, UK Biobank is unusual in that only 6% of people invited to take part in its initial survey agreed to do so. UK Biobank participants tend to have a more favourable risk factor profile and lower mortality than the general population of the same age. The low response rate has led to debate as to whether findings of links between risk factors and disease from UK Biobank are likely to be generalizable. We compared associations between risk factors for chronic disease and mortality in UK Biobank with nationally representative cohort studies which had conventional response rates. Associations of a wide range of risk factors with mortality outcomes showed close agreement between studies. Risk factor associations in UK Biobank seem to be generalisable

Application 10279

The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation

The proposed research aims to understand why it is that poorer cognitive function and negative emotional factors are typically associated with poorer health and increased mortality. We shall use health outcome data to examine how all-cause mortality and incident cancer and cardiovascular disease (CVD)vary according to prior cognitive function and negative emotions. We shall investigate the extent to which relationships we find between cognition, emotions and these health outcomes are explained or modified by physical, biological, genetic, behavioural, and socio-demographic factors. Genetic analyses will incorporate multivariate genome-wide complex trait analysis and polygenic prediction of these relationships. Poorer cognitive function and negative emotional states and traits have been shown to increase mortality but the reasons for this are unclear. We anticipate that the proposed research will: 1) show us how mortality and morbidity from common health conditions vary according to prior cognitive abilities and emotional factors; 2) reveal potential mechanisms whereby poorer cognition and negative emotion increase risk; and 3) identify whether other characteristics can increase or reduce the risk of ill health in those with poorer cognition and negative emotions. This information could help inform intervention strategies for preventing or treating common health conditions. Using data on cognitive function and negative emotions together with data collected on health outcomes, scientists at the Centre for Cognitive Ageing and Cognitive Epidemiology will examine whether cognitive performance and emotional states predict risk of all-cause mortality and the onset of cancer and CVD. They will investigate whether other characteristics, such as lifestyle, socio-demographic, physical, behavioural or biological factors, help to explain any links between cognitive function and emotions and these health outcomes. They will estimate degree of genetic sharing between: 1) cognitive function/emotions and these characteristics, and 2) cognitive function/emotions and health outcomes. The full cohort

Lead investigator:	Dr Michelle Luciano
Lead institution:	University of Edinburgh

13 related Returns

Return ID	App ID	Description	Archive Date
2837	10279	Assessment of Relative Utility of Underlying vs Contributory Causes of Death	20 Nov 2020
3148	10279	Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism	26 Feb 2021
2836	10279	Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank	20 Nov 2020
2772	10279	GWAS on family history of Alzheimer's disease	3 Nov 2020
1522	10279	Genetic prediction of male pattern baldness	2 Aug 2018
2771	10279	Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function	3 Nov 2020
760	10279	Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112151)	17 Oct 2017
762	10279	Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions	17 Oct 2017
796	10279	Psychological distress, neuroticism, and cause-specific mortality: early prospective idence from UK Biobank	19 Oct 2017
2786	10279	Psychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies	4 Nov 2020
3744	10279	Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study based on a community sample	12 Aug 2021
3184	10279	The influence of X chromosome variants on trait neuroticism	9 Mar 2021
1850	10279	When Is Higher Neuroticism Protective Against Death? Findings From UK Biobank	6 Dec 2019

1 Publication

Pub ID	Title	Author(s)	Year	Journal
2839	Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: prospective cohort study and individual participant meta-analysis	G David Batty (+4)	2020	The BMJ

Application:	10279, The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation
Title:	Comparison of risk factor associations in UK Biobank against representative, gen pop based studies with conventional response rates: prospective cohort study and individual participant meta-analysis
Size:	159722 B
Cost Tier:	1
Archived:	20 Nov 2020
Stability:	Complete
Personal:	No individual-level data