| Title: | Tea consumption and attenuation of biological aging: a longitudinal analysis from two cohort studies |
| Journal: | The Lancet Regional Health - Western Pacific |
| Published: | 22 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38075587/ |
| DOI: | https://doi.org/10.1016/j.lanwpc.2023.100955 |
| URL: | http://www.thelancet.com/article/S2666606523002730/pdf |
Publication 9259
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Abstract
Background: The biological aging process can be modified through lifestyle interventions to prevent age-related diseases and extend healthspan. However, evidence from population-based studies on whether tea consumption could delay the biological aging process in humans remains limited.</p>
Methods: This study included 7931 participants aged 30-79 years from the China Multi-Ethnic Cohort (CMEC) Study and 5998 participants aged 37-73 years from the UK Biobank (UKB) who participated in both the baseline and first follow-up surveys. Tea consumption information was collected through questionnaires. Biological age (BA) acceleration was calculated using clinical biomarkers and anthropometric measurements based on the Klemera Doubal method (KDM). Change-to-change analyses were performed to estimate the associations between changes in tea consumption status and changes in BA acceleration using multiple linear models. Follow-up adjusted for baseline analyses were further conducted to examine the prospective exposure-response relationship between tea consumption and BA acceleration among individuals with constant tea consumption status.</p>
Findings: During a median follow-up of 1.98 (1.78, 2.16) years in the CMEC and 4.50 (3.92, 5.00) years in the UKB, tea consumption was consistently associated with attenuated BA acceleration in both cohorts. Transitioning from nondrinking to tea-drinking was associated with decreased BA acceleration (CMEC: β = -0.319, 95% CI: -0.620 to -0.017 years; UKB: β = -0.267, 95% CI: -0.831 to 0.297 years) compared to consistent nondrinking. Even stronger associations were found in consistent tea drinkers. The exposure-response relationship suggested that consuming around 3 cups of tea or 6-8 g of tea leaves per day may offer the most evident anti-aging benefits.</p>
Interpretation: Tea consumption was associated with attenuated BA acceleration measured by KDM, especially for consistent tea drinkers with moderate consumption. Our findings highlight the potential role of tea in developing nutrition-oriented anti-aging interventions and guiding healthy aging policies.</p>
Funding: National Natural Science Foundation of China (Grant No. 82273740).</p>
13 Authors
- Yi Xiang
- Hao Xu
- Hongxiang Chen
- Dan Tang
- Zitong Huang
- Yuan Zhang
- Zhenghong Wang
- Ziyun Wang
- Yangla
- Mingming Han
- Jianzhong Yin
- Xiong Xiao
- Xing Zhao
1 Application
| Application ID | Title |
|---|---|
| 117185 | Research on risk factors and pathogenesis of aging-related chronic diseases |
Enabling scientific discoveries that improve human health