| Title: | Associations of body roundness index with steatotic liver disease and mortality from the UK biobank cohort study |
| Journal: | BMC Gastroenterology |
| Published: | 10 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41963819/ |
| DOI: | https://doi.org/10.1186/s12876-026-04679-8 |
Publication 18032
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundSteatotic liver disease (SLD) is a chronic condition associated with cardiometabolic risk. The body roundness index (BRI) is a novel visceral adiposity marker. We evaluate the associations between BRI and risks of SLD, major adverse liver-related outcomes (MALO), liver-related mortality, and all-cause mortality using the UK Biobank cohort.MethodsData from 399,115 participants (aged 37-73 years) without baseline SLD or MALO were analyzed. BRI was categorized into sex-specific quartiles. Outcomes were identified via national health records. Adjusted hazard ratios (HRs) were estimated using Fine-Gray competing risk models and Cox proportional hazards models.ResultsDuring a median follow-up of 13.9 years, the incidence of SLD, MALO, liver-related mortality, and all-cause mortality was 1.38%, 1.25%, 0.24%, and 8.31%, respectively. Higher BRI was significantly associated with increased SLD risk (HR 6.20; 95% CI 5.28-7.28), with a more pronounced association in women (HR 9.11) than in men (HR 3.38). Significant non-linear, J-shaped associations were observed for SLD and all-cause mortality (both p for nonlinearity < 0.001). Conversely, MALO and liver-related mortality showed linear positive associations (p for nonlinearity > 0.05), with significant risks primarily observed in the highest BRI quartiles.ConclusionHigher BRI is significantly associated with increased risks of SLD, MALO, and bothliver-related and all-cause mortality. These findings suggest that BRI is a valuable tool for identifying individuals at risk of adverse hepatic outcomes, potentially offering predictive utility beyond conventional anthropometric indices.</p>
5 Authors
- Jinyoung Shin
- Seok-Jae Heo
- Yae-Ji Lee
- Yu-Jin Kwon
- Ji-Won Lee
1 Application
| Application ID | Title |
|---|---|
| 477427 | Investigating the Impact of Physical Exercise and Activity Levels on Dementia Risk |
Enabling scientific discoveries that improve human health