| Application: | 17765, Identifying causes of the allergy and asthma epidemics by using genetic biomarkers of exposures |
| Title: | Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis |
| Size: | 13744 B |
| Archived: | 30 Oct 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2705
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Notes
Observational analyses showed that ever-drinking versus non-drinking was positively associated with hay fever and inversely with asthma, but not with allergic sensitization and serum total IgE. In contrast, genetic predisposition to consume more alcohol did not affect risk of hay fever, asthma, allergic sensitization or serum levels of total IgE. The discrepancy of results between observational and Mendelian randomization analyses could be due to potential residual confounding, e.g. by socioeconomic or life-style factors. Our results challenge the concept of a risk-increasing effect of alcohol consumption on allergic disease and asthma.Application 17765
Identifying causes of the allergy and asthma epidemics by using genetic biomarkers of exposures
The prevalence of allergic diseases and asthma has increased in Westernized countries. Our goal is to identify risk factors by a number of genetic epidemiological studies. We aim to take advantage of genetic differences in exposure to potential risk factors to determine unbiased estimates of their causal effects on hay fever, eczema and asthma. This approach is also known as Mendelian Randomization and has been used for various exposures and diseases, but until now few studies have looked at hayfever, eczema, and asthma. No new sampling or contact to participants are needed to carry out this proposal. The increasing prevalence of allergic diseases and asthma has great public health significance. There is limited knowledge about the responsible risk factors and therefore it is difficult to develop effective preventive strategies. We hope to improve knowledge about the factors that increase the risk of allergic diseases and asthma and hope to contribute to the development of preventive strategies. Thus, we believe this project is in accordance with the purpose of the UK Biobank, since it is both health-related research and in the public interest. We will use information already available in the UK Biobank to estimate effects of possible risk factors for hayfever, eczema, asthma and the autoimmune disease, ceilac disease. Genetic variants associated with exposure to the risk factors will be used as unbiased markers of exposure to these factors. The risk factors to be investigated are vitamins (Vitamin D, vitamin C, Vitamin B12, folate), alcohol intake, coffee drinking, milk drinking, testosterone, obesity, height, and age of menopause. Thus, genetic variants associated with life-long exposure to these factors will be employed. The full cohort is needed for this proposal. The concept of Mendelian Randomization needs large populations to produce precise estimates of causal effects of risk factors.
| Lead investigator: | Professor Allan Linneberg |
| Lead institution: | Research Centre for Prevention and Health |
2 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 2084 | 17765 | Associations of genetic determinants of serum vitamin B12 and folate concentrations with hayfever and asthma: a Mendelian randomization meta-analysis | 3 Mar 2020 |
| 2102 | 17765 | Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization | 4 Mar 2020 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2706 | Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis | Skaaby T et al. | 2019 | Addiction |
Enabling scientific discoveries that improve human health