| Application: | 7155, Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
| Title: | Associations Between Diabetes and Both Cardiovascular Disease and All-Cause Mortality Are Modified by Grip Strength: Evidence From UK Biobank, a Prospective Population-Based Cohort Study |
| Size: | 541611 B |
| Archived: | 2 Dec 2019 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 1846
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Notes
Grip strength and diabetes are predictors of mortality and cardiovascular disease (CVD), but whether these risk factors interact to predispose to adverse health outcomes is unknown. This study determined the interactions between diabetes and grip strength and their association with health outcomes.We undertook a prospective, general population cohort study by using UK Biobank. Cox proportional hazards models were used to explore the associations between both grip strength and diabetes and the outcomes of all-cause mortality and CVD incidence/mortality as well as to test for interactions between diabetes and grip strength.
A total of 347,130 UK Biobank participants with full data available (mean age 55.9 years, BMI 27.2 kg/m2, 54.2% women) were included in the analysis, of which 13,373 (4.0%) had diabetes. Over a median follow-up of 4.9 years (range 3.3 7.8 years), 6,209 died (594 as a result of CVD), and 4,301 developed CVD. Participants with diabetes were at higher risk of all-cause and CVD mortality and CVD incidence. Significant interactions (P < 0.05) existed whereby the risk of CVD mortality was higher in participants with diabetes with low (hazard ratio [HR] 4.05 [95% CI 2.72, 5.80]) versus high (HR 1.46 [0.87, 2.46]) grip strength. Similar results were observed for all-cause mortality and CVD incidence.
Application 7155
Epidemiology of mental health, cognitive function, pain and cardiometabolic disease.
Mental health problems place a large burden on the health service. As life expectancy increases, understanding cognitive decline is increasingly important. Identifying high risk groups enables us to detect problems early and target resources. Understanding the distribution of disease between groups can help elucidate the causes of disease and help identify new methods of prevention and treatment. Aim: To study the epidemiology of mental health, cognitive function, pain and cardiometabolic disease. Objectives: To examine the frequency, distribution, determinants and outcomes of these conditions, in relation to: demographics, lifestyle, comorbidity and medication UKB is representative of the general population in terms of age, sex and ethnicity but unrepresentative in terms of lifestyle. Therefore, it is not suitable to determine the overall prevalence of any condition but can, nonetheless, be used to compare the distribution of diseases between sub-groups and therefore determine associations between risk factors and disease frequency and outcome. This project builds on our ongoing study (774) which examines ethnic differences in cardiometabolic disease. We seek to extend the focus to examine other determinants of cardiometabolic disease as well as determinants of mood disorder, cognitive impairment and pain. We will compare participants with and without mood disorder, pain, cognitive impairment and cardiometabolic diease and participants with varying severity of these conditions in relation to a series of demographic and lifestyle factors in order to determine the factors associated with the conditions. We will also examine the association between these conditions and other diseases. The findings will help to identify individual at increased risk and modifiable factors that may help to prevent or alleviate these conditions. all participants
| Lead investigator: | Professor Jill Pell |
| Lead institution: | University of Glasgow |
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|---|---|---|---|
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| 1476 | 7155 | Chronic multisite pain in major depression and bipolar disorder: cross-sectional study of 149, 611 participants in UK Biobank | 5 Jul 2018 |
| 2830 | 7155 | Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank | 18 Nov 2020 |
| 1682 | 7155 | PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study | 29 Jul 2019 |
| 1781 | 7155 | Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis | 30 Sep 2019 |
| 2858 | 7155 | The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants | 24 Nov 2020 |
| 3675 | 7155 | Vitamin D and COVID-19 infection and mortality in UK Biobank | 27 Jul 2021 |
| 3674 | 7155 | Vitamin D concentrations and COVID-19 infection in UK Biobank | 27 Jul 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 1847 | Associations Between Diabetes and Both Cardiovascular Disease and All-Cause Mortality Are Modified by Grip Strength: Evidence From UK Biobank, a Prospective Population-Based Cohort Study | Carlos A Celis-Morales (+12) | 2017 | Diabetes Care |
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