| Application: | 7155, Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
| Title: | Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants |
| Size: | 188436 B |
| Archived: | 2 Dec 2019 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 1842
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Notes
The aim of this study was to investigate the association of grip strength with disease specific incidence and mortality and whether grip strength enhances the prediction ability of an established office based risk score.502,293 participants (54% women) aged 40-69 years from the UK Biobank participants were included in this study.
Higher grip strength was associated with a range of health outcomes and improved prediction of an office based risk score. Further work on the use of grip strength in risk scores or risk screening is needed to establish its potential clinical utility.
Application 7155
Epidemiology of mental health, cognitive function, pain and cardiometabolic disease.
Mental health problems place a large burden on the health service. As life expectancy increases, understanding cognitive decline is increasingly important. Identifying high risk groups enables us to detect problems early and target resources. Understanding the distribution of disease between groups can help elucidate the causes of disease and help identify new methods of prevention and treatment. Aim: To study the epidemiology of mental health, cognitive function, pain and cardiometabolic disease. Objectives: To examine the frequency, distribution, determinants and outcomes of these conditions, in relation to: demographics, lifestyle, comorbidity and medication UKB is representative of the general population in terms of age, sex and ethnicity but unrepresentative in terms of lifestyle. Therefore, it is not suitable to determine the overall prevalence of any condition but can, nonetheless, be used to compare the distribution of diseases between sub-groups and therefore determine associations between risk factors and disease frequency and outcome. This project builds on our ongoing study (774) which examines ethnic differences in cardiometabolic disease. We seek to extend the focus to examine other determinants of cardiometabolic disease as well as determinants of mood disorder, cognitive impairment and pain. We will compare participants with and without mood disorder, pain, cognitive impairment and cardiometabolic diease and participants with varying severity of these conditions in relation to a series of demographic and lifestyle factors in order to determine the factors associated with the conditions. We will also examine the association between these conditions and other diseases. The findings will help to identify individual at increased risk and modifiable factors that may help to prevent or alleviate these conditions. all participants
| Lead investigator: | Professor Jill Pell |
| Lead institution: | University of Glasgow |
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| 1846 | 7155 | Associations Between Diabetes and Both Cardiovascular Disease and All-Cause Mortality Are Modified by Grip Strength: Evidence From UK Biobank, a Prospective Population-Based Cohort Study | 2 Dec 2019 |
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| 1781 | 7155 | Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis | 30 Sep 2019 |
| 2858 | 7155 | The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants | 24 Nov 2020 |
| 3675 | 7155 | Vitamin D and COVID-19 infection and mortality in UK Biobank | 27 Jul 2021 |
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1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 1843 | Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants | Carlos A Celis-Morales (+13) | 2018 | The BMJ |
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