| Title: | Gene-environment interaction analysis on age-related diseases |
| Lead Institution: | Shanghai Jiao Tong University |
| Principal investigator: |
Application 99001
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About
Population ageing is inevitable and may result in soaring global burdens for multiple age-related diseases, especially cardiovascular diseases, cancers, type 2 diabetes mellitus, and neurodegenerative diseases. Independent effects of various risk gene and environmental stressors on the age-related diseases were well-documented, but studies about gene-environment interactions on the diseases were limited. This study is designed to identify key factors about the initiation or progression of age-related diseases through gene-wide association study (GWAS) and environment-wide association study (EWAS), then conduct gene-environment interaction analysis to further reconstruct intrinsic pathways from risk factors to the diseases. Results of the study would contribute to revealing complex disease mechanisms, promoting personalized medicine, and preventing age-related diseases.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 8648 | Associations of Triglycerides and Atherogenic Index of Plasma with Brain Structure in the Middle-Aged and Elderly Adults | Xixi Chen (+9) | 2024 | Nutrients |
| 12807 | Chronic Low-Grade Inflammation and Brain Structure in the Middle-Aged and Elderly Adults | Yujia Bao (+6) | 2024 | Nutrients |
Enabling scientific discoveries that improve human health